CANF News & Events

Can-Fite BioPharma announced that a patient with advanced decompensated liver cirrhosis who was treated with Namodenoson subsequently underwent a successful liver transplantation. The patient received Namodenoson treatment under a compassionate use framework while suffering from liver disease and complications consistent with decompensated cirrhosis. Throughout the treatment period, Namodenoson contributed to clinical stabilization, allowing the patient to remain a suitable candidate for liver transplantation until a compatible donor organ became available, ultimately resulting in a successful, life-saving liver transplantation. While this is a single case, the outcome suggests a potential supportive role for Namodenoson in patients with severe liver dysfunction awaiting transplantation.

Can-Fite BioPharma announced that patient enrollment has been completed in its Phase 2a pancreatic cancer clinical trial of Namodenoson. The study is evaluating the safety, clinical activity, and pharmacokinetics of Namodenoson in patients with advanced pancreatic adenocarcinoma whose disease has progressed following at least one line of prior therapy. Participants receive oral Namodenoson at a dose of 25 mg, administered twice daily in continuous 28-day cycles. "This achievement marks a significant step forward in the clinical development of Namodenoson in pancreatic cancer," said Pnina Fishman, Ph.D., Chief Scientific Officer of Can-Fite BioPharma. "With enrollment now complete and safety continuing to be favorable, we believe we are well positioned to generate meaningful efficacy top-line data in Q3 2026."

Can-Fite BioPharma announced that the Brazilian Patent Office has granted Patent No. BR112015002697-4, entitled "Use of an A3 Adenosine Receptor Agonist for the Treatment of Sexual Dysfunction." The granted patent provides intellectual-property protection in Brazil for the use of Can-Fite's proprietary A3AR agonists in the treatment of sexual dysfunction, further strengthening the Company's global patent portfolio. Brazil represents one of the largest pharmaceutical markets in Latin America, with a growing demand for innovative therapies addressing sexual health conditions. Sexual dysfunction is associated with vascular, inflammatory, and metabolic pathways. Preclinical and clinical data generated by Can-Fite suggest that activation of the A3 adenosine receptor may modulate key signaling mechanisms involved in erectile and sexual function, supporting the therapeutic rationale underlying the patent.