Kyverna Therapeutics, Immunome, Almonty Industries, and Other Major Stocks Rise on Monday
U.S. Stock Market Performance: U.S. stocks declined, with the Nasdaq Composite dropping over 100 points on Monday.
Kyverna Therapeutics Surge: Kyverna Therapeutics Inc. shares rose 31% to $11.49 following the announcement of positive topline data from its Phase 2 trial of mivocabtagene autoleucel for stiff person syndrome.
Other Notable Stock Gains: Beneficient, Immunome Inc., and Falcon’s Beyond Global recorded significant gains, with increases of 29.3%, 25.5%, and 14% respectively.
Additional Stock Movements: Several other companies, including Almonty Industries and NovaBay Pharmaceuticals, also saw notable increases in their stock prices, contributing to a generally positive day for select stocks despite the overall market decline.
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- Investor Conference Schedule: Olema Pharmaceuticals will participate in the Guggenheim Securities Emerging Outlook: Biotech Summit on February 11, 2026, featuring a fireside chat aimed at enhancing the company's visibility among investors and showcasing its R&D progress.
- Virtual Conference Participation: The company will also attend Citi's 2026 Virtual Oncology Leadership Summit on February 19, 2026, continuing to engage with investors through virtual platforms, adapting to current market trends.
- Industry Conference Appearance: Olema will be present at the Oppenheimer 36th Annual Healthcare Life Sciences Conference on February 26, 2026, further expanding its influence in the biopharmaceutical industry and attracting potential investor interest.
- Pipeline Progress: Olema's lead candidate, palazestrant, is currently in two Phase 3 clinical trials, demonstrating the company's commitment and potential in breast cancer treatment, which may lay the groundwork for future market performance.
- Stock Option Grant: Olema Pharmaceuticals granted stock options for a total of 24,000 shares to two new employees effective February 2, 2026, a move approved by the Compensation Committee aimed at attracting talent and enhancing employee loyalty.
- Exercise Price: The stock options have an exercise price of $25.65 per share, matching the last reported sale price on Nasdaq on February 2, 2026, which aligns employee incentives with company performance.
- Vesting Schedule: The options vest over four years, with 25% vesting on the first anniversary and the remainder vesting in 36 equal monthly installments, ensuring employees remain with the company to fully benefit from the options.
- Clinical Development Progress: Olema focuses on targeted therapies for breast cancer and is advancing its lead candidate, palazestrant, through two Phase 3 clinical trials, highlighting the company's ongoing innovation and market potential in the biopharmaceutical sector.
- Executive Departure: Olema Pharmaceuticals' Chief Operating and Financial Officer Shane Kovacs will leave the company on January 30, 2026, although he will continue as a consultant until August 1, 2026, which may impact the company's financial strategy and operational stability.
- Interim Appointment: Bohen has been appointed as the interim Chief Financial Officer while the search for a new CFO begins, ensuring continuity in financial management and reducing uncertainty associated with executive transitions.
- Market Reaction: Olema's stock fell 2.86% in after-hours trading to $24.98, reflecting investor concerns over the executive departure, which could affect the company's future financing and investor confidence.
- Public Offering Impact: Olema recently completed a $190 million public offering, and while the executive changes may exert short-term pressure on the stock price, the successful fundraising indicates market confidence in the company's long-term potential.
- Put Option Appeal: The current bid for the $25.00 put option is $4.00, and if an investor sells this contract, their effective purchase price for the stock drops to $21.00, representing a 2% discount from the current price of $25.64, making it attractive for those interested in OLMA shares.
- Yield Potential: Should the put option expire worthless, it would yield a 16% return on the cash commitment, equating to an annualized return of 55.64%, highlighting the potential attractiveness of this investment strategy.
- Call Option Returns: The $26.00 call option has a current bid of $4.60, and if an investor buys OLMA shares at $25.64 and sells this contract, they could achieve a total return of 19.34% if the stock is called away at expiration, showcasing the profit potential of this strategy.
- Risk Assessment: Current analytics indicate a 65% chance that the $25.00 put option will expire worthless, while the $26.00 call option has a 37% chance of doing so, necessitating careful evaluation of the risk-reward balance for investors.
- Glaukos Sales Projection: Glaukos Corp anticipates FY25 sales of $507 million, yet its shares fell 12.1% in pre-market trading, indicating market concerns about its growth outlook despite the positive sales forecast.
- Briacell's Sharp Decline: Briacell Therapeutics' announcement of a $30 million public offering led to a staggering 53.1% drop in its stock price during pre-market trading, reflecting investor apprehension regarding the financing strategy.
- Trip.com Investigation Impact: Trip.com Group confirmed it is under investigation by China's SAMR for potential anti-monopoly violations, resulting in a 9.3% decline in its pre-market stock price, which may adversely affect its market performance and investor confidence.
- Pearson Trading Update: Pearson PLC's trading update for 2025 caused its shares to drop 7.2% in pre-market trading, indicating a cautious market sentiment regarding its future performance.
- Complete Equity Exit: Olema Pharmaceuticals board member Ian T. Clark executed a disposition of 264,800 shares through option exercise and immediate sale, totaling $7.9 million, marking a complete exit from direct equity holdings with both direct and indirect ownership now at zero.
- Option-Driven Transaction: The transaction was executed through the exercise of options followed by an immediate sale, indicating that the entire event was driven by option-related mechanics rather than an open-market disposition of long-held equity.
- Strong Stock Performance: The weighted average sale price of $29.73 per share was 7.5% above the market close of $27.93 on December 19, reflecting a monetization opportunity after a remarkable 326.50% stock surge over the past year.
- Stable Financial Position: Despite Olema's R&D spending rising to $40 million in Q3 and a net loss widening to $42.2 million, the company maintains $329 million in cash and marketable securities, ensuring operational runway into 2028.










