Alnylam Pharmaceuticals hits a 20-day low amid market decline
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Feb 01 2026
0mins
Should l Buy ALNY?
Source: Coinmarketcap
Alnylam Pharmaceuticals Inc. experienced a price drop of 3.13%, hitting a 20-day low. This decline comes as the broader market also faced challenges, with the Nasdaq-100 down 0.75% and the S&P 500 down 0.31%.
The stock's movement is attributed to broad market weakness, as the company announced a repurchase of approximately $34.4 million of its convertible senior notes for a total cost of about $51.9 million. This proactive management of its capital structure is expected to enhance financial flexibility and capital allocation efficiency, but the overall market sentiment remains cautious.
Investors are closely monitoring Alnylam's strategic decisions, particularly in light of the repurchase, which may influence future shareholder value and market confidence. The company's efforts to optimize its capital structure could position it favorably for future growth in the RNA interference therapeutics space.
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Analyst Views on ALNY
Wall Street analysts forecast ALNY stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALNY is 500.28 USD with a low forecast of 351.00 USD and a high forecast of 570.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
20 Analyst Rating
16 Buy
4 Hold
0 Sell
Strong Buy
Current: 331.240
Low
351.00
Averages
500.28
High
570.00
Current: 331.240
Low
351.00
Averages
500.28
High
570.00
About ALNY
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR) with polyneuropathy in adults; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Fitusiran, Zilebesiran, Elebsiran, Mivelsiran and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Amvuttra Sales Surge: In Q3 2025, Amvuttra's sales skyrocketed by 162% year-over-year, primarily driven by rapid adoption in the transthyretin cardiac amyloidosis (ATTR-CM) indication, which is expected to boost Q4 performance.
- Market Performance: Although Alnylam's market share remains limited in international markets, particularly in Q4, stronger growth is anticipated in Germany and Japan in 2026, reflecting the company's strategic positioning in global markets.
- Pipeline Updates: Alnylam is expected to provide updates on its pipeline progress in the upcoming earnings report, including the initiation of a Phase 3 study for hereditary ATTR with polyneuropathy and a Phase 2 trial for Alzheimer's disease, showcasing ongoing R&D advancements.
See More
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- Inclusion Candidates: According to a report by Stephens, large-cap stocks like Marvell Technology, Vertiv, Strategy, Reddit, and Alnylam Pharmaceuticals meet the eligibility criteria for S&P 500 inclusion, drawing investor attention.
- Performance Expectations: Newly added S&P 500 constituents typically perform strongly post-announcement, prompting investors to closely monitor these candidates ahead of the U.S. Index Committee's reshuffle scheduled for Friday.
- Sector Dynamics Impact: Communication services and financials are underweight in the index relative to their market size, increasing the likelihood of Reddit and SoFi Technologies' inclusion, with the latter being the most liquid financial candidate.
- M&A Activity Potential: Data center infrastructure provider Vertiv could benefit from pending M&A activity that may create vacancies in the S&P 500, further enhancing its chances of inclusion.
See More
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- Performance Breakthrough: Alnylam Pharmaceuticals achieved nearly $3 billion in sales in 2025 and projects sales of up to $5.3 billion in 2026, demonstrating strong growth potential in the rare disease sector.
- R&D Progress: Ultragenyx anticipates two gene therapy approvals in 2026 despite facing clinical trial setbacks in 2025, indicating ongoing investment and risk management in its development pipeline.
- Regulatory Support: The FDA's recent implementation of the Rare Disease Evidence Principles framework allows for therapy approvals based on single-arm studies, showcasing support for rare disease developers and potentially accelerating new therapies to market.
- Financial Outlook: PTC closed 2025 with $1.94 billion in cash reserves and plans to continue the global launch of its flagship product Sephience in 2026, aiming for break-even cash flow, reflecting robust development in the market.
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- Surge in Metal Prices: Gold and silver prices soared to all-time highs, driving mining stocks higher, with Hecla Mining and Coeur Mining gaining over 8% and 5% respectively, reflecting strong investor interest in precious metals.
- Economic Data Focus: The market is set to focus on upcoming economic data releases, including December CPI and PPI, which are expected to influence future monetary policy amid political pressures on the Federal Reserve.
- Earnings Season Kickoff: S&P 500 companies are projected to see an 8.4% earnings growth in Q4, while excluding the Magnificent Seven tech giants, earnings growth is expected at 4.6%, providing crucial signals for investors.
See More
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- Market Volatility: The S&P 500 Index rose by 0.28%, the Dow Jones Industrial Average increased by 0.15%, and the Nasdaq 100 climbed by 0.55%, despite heightened concerns over Fed independence due to the Trump administration's attacks, leading to a 'Sell America' sentiment in US asset markets.
- Credit Card Companies Hit: President Trump stated that credit card lenders would be 'in violation of the law' if they do not cap interest rates at 10% for one year, causing significant declines in credit card and bank stocks, with Synchrony Financial down over 7% and Capital One Financial down over 6%.
- Gold Prices Surge: Gold and silver prices soared to new all-time highs, driving mining stocks higher, with Hecla Mining up over 8% and Coeur Mining up over 6%, reflecting strong investor demand for safe-haven assets amid market uncertainty.
- Fed Faces Legal Threats: Fed Chair Powell indicated that the threat of criminal charges stems from the Fed's refusal to comply with Trump's calls for lower interest rates, which could impact future policy decisions and create greater uncertainty in market expectations regarding interest rate movements.
See More
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- Market Pressure Intensifies: The S&P 500, Dow Jones, and Nasdaq 100 indices fell by 0.03%, 0.18%, and 0.07% respectively, as Trump's administration's attacks on the Federal Reserve raised concerns about its independence, indicating a bearish sentiment in U.S. asset markets.
- Gold and Silver Surge: Following Fed Chair Powell's warning of potential criminal charges, gold and silver prices soared to new all-time highs, boosting mining stocks and reflecting a growing demand for safe-haven assets amid market uncertainty.
- Credit Card Companies Hit: Trump's statement that credit card lenders would be
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