Novavax Licenses Matrix-M® Adjuvant to Pfizer for Two Disease Areas
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 20 2026
0mins
Should l Buy NVAX?
Source: PRnewswire
- License Agreement Signed: Novavax has entered into a licensing agreement with Pfizer, granting Pfizer a non-exclusive license for the Matrix-M® adjuvant to be used in the development of products across two disease areas, highlighting the market potential of Novavax's technology.
- Future Application Prospects: Novavax's CEO John C. Jacobs stated that this collaboration further demonstrates the potential utility of Matrix-M® technology in new product development, which could drive future vaccine research and development.
- Strategic Partnership Expansion: This agreement is part of Novavax's strategy to expand partnerships and applications of its technology platform, aiming to optimize existing collaborations and enhance market competitiveness through research and development innovation.
- Future Development Risks: Novavax cautions investors that the development and commercialization of future vaccines face various risks, including regulatory authorization challenges, clinical trial delays, and raw material shortages, necessitating careful assessment of potential uncertainties.
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Analyst Views on NVAX
Wall Street analysts forecast NVAX stock price to rise
6 Analyst Rating
3 Buy
0 Hold
3 Sell
Hold
Current: 8.420
Low
6.00
Averages
10.50
High
18.00
Current: 8.420
Low
6.00
Averages
10.50
High
18.00
About NVAX
Novavax, Inc. is a biotechnology company. It is focused on addressing global health challenges through its vaccines and its proven technology platform, including protein-based nanoparticles and its Matrix-M adjuvant. Matrix-M can be used to create vaccines for a variety of diseases to help tackle some of the pressing health challenges. Its proprietary Matrix-M adjuvant, when added to vaccines, has been shown to help induce a stronger and longer-lasting immune response. Its recombinant protein-based nanoparticle technology has been shown to be highly immunogenetic. Its technology platform is used in its authorized COVID-19 vaccine and the R21/Matrix-M adjuvant malaria vaccine. Its late-stage programs include a COVID-19-Influenzavaccine candidate, and an influenza vaccine candidate. R21/Matrix-M adjuvant malaria vaccine, a malaria vaccine developed by its partner. It provides Matrix-M adjuvant for use in various programs in preclinical and clinical stage, and preclinical investigations.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Seeking Further Clarity: CEO Stephane Bancel indicated that the company will request a Type A meeting with the FDA to clarify the rejection, highlighting inconsistencies with prior FDA guidance that had allowed the use of a licensed standard-dose vaccine as a comparator.
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- Regulatory Rejection: The FDA's refusal to file Moderna's flu vaccine application, citing a lack of a comparator reflecting the 'best-available standard of care' despite no safety or efficacy concerns, resulted in a nearly 9% drop in MRNA shares during after-hours trading.
- Clinical Trial Data: The biologics license application included two positive Phase 3 studies with 43,808 participants, one showing a stronger immune response in adults aged 65 and older and the other demonstrating higher effectiveness in adults aged 50 and older, yet the FDA did not accept the application.
- Seeking Further Clarity: CEO Stephane Bancel indicated that the company will request a Type A meeting with the FDA to clarify the rejection, highlighting inconsistencies with prior FDA guidance that had allowed the use of a licensed standard-dose vaccine as a comparator.
- Market Reaction and Outlook: Despite the FDA's decision adding regulatory uncertainty for vaccine manufacturers, Moderna plans to submit applications in other countries by 2026 and expects potential approvals outside the U.S. in late 2026 or early 2027, reflecting ongoing confidence in future market opportunities.
See More
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- Earnings Release Announcement: Pfizer is set to release its Q4 earnings before the market opens on February 3, with analysts projecting earnings per share of 57 cents, down from 63 cents a year ago, indicating a potential decline in profitability.
- Revenue Expectations Decline: The consensus estimate for Pfizer's quarterly revenue stands at $16.83 billion, a decrease from $17.76 billion in the previous year, suggesting that weakening market demand may impact the company's overall performance.
- Stock Price Movement: Ahead of the earnings report, Pfizer's stock rose 1.4% to close at $26.44 on Friday, reflecting some investor confidence despite the unfavorable earnings outlook.
- Collaboration Agreement Update: On January 20, Novavax announced a licensing agreement with Pfizer for the use of its Matrix-M adjuvant, which could provide a new growth avenue for Pfizer's product line, even as short-term financial performance faces challenges.
See More
Novavax Faces Challenges Despite Recent Gains
- Market Value Decline: Over the past five years, Novavax has seen its market value drop by more than 90%, and although it successfully launched a coronavirus vaccine, it struggled to maintain competitive sales against market leaders, resulting in significant financial challenges for the company.
- Licensing Agreement: Novavax entered a non-exclusive licensing deal with Pfizer, securing a $30 million upfront payment and potential milestone payments of up to $500 million, along with royalties on future products, providing a potential revenue boost for the company.
- Vaccine Development Setbacks: While Novavax is working on a flu vaccine and a combination coronavirus/flu vaccine, progress has been hindered by a clinical hold on phase 3 studies, and increasing competition in the market may impact future sales performance.
- Uncertain Market Outlook: With U.S. regulators changing recommendations on coronavirus vaccines, Novavax's revenue outlook has become more uncertain, and despite potential collaboration opportunities, the overall market environment remains challenging.
See More
Pfizer Shares Rise on Upgraded Price Forecast
- Forecast Upgrade: Cantor Fitzgerald raised Pfizer's price forecast from $24 to $27, providing a positive catalyst for the pharmaceutical giant despite a 1.6% decline in the broader healthcare sector.
- Licensing Agreement: Pfizer entered a non-exclusive licensing agreement with Novavax for its Matrix-M adjuvant technology, granting Novavax a $30 million upfront payment and potential milestones up to $500 million, indicating Pfizer's proactive approach in product development.
- FDA Breakthrough Therapy: Pfizer's Sutent, in combination with Cogent Biosciences' bezuclastinib, received FDA Breakthrough Therapy Designation after showing a 50% reduction in disease progression risk, enhancing Pfizer's competitive edge in oncology treatments.
- Leadership Warning: At the World Economic Forum, CEO Albert Bourla warned that reduced funding for U.S. universities has weakened America's position in global health research, highlighting China's dominance in health research rankings.
See More
Novavax Partners with Pfizer in Key Licensing Deal
- Pfizer Licensing Agreement: Novavax has entered a non-exclusive licensing agreement with Pfizer, allowing the latter to use Novavax's Matrix-M adjuvant, resulting in a $30 million upfront payment and potential development and sales milestones totaling up to $500 million, significantly enhancing Novavax's ability to monetize its vaccine platform.
- Financial Support Boost: This agreement enables Novavax to secure non-dilutive cash flow and ongoing royalties from future product sales, which can fund late-stage programs, improve its balance sheet, and extend its cash runway, thereby reducing development and marketing risks.
- Increased Focus on Respiratory Illnesses: With rising flu and RSV activity in the U.S., Novavax's vaccine technology has gained relevance, leading to heightened investor interest in its seasonal and respiratory vaccines, further driving the company's stock price upward.
- Strong Market Performance: Novavax shares surged 5.67% to $9.69 on Monday, trading 25.4% and 25.5% above its 20-day and 100-day simple moving averages, indicating a robust short-term market trend.
See More
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- Analyst Rating Divergence: Despite Moderna's 39% stock price increase over the past year, analysts remain cautious, assigning a ‘Hold’ rating with a price target of $37.40, indicating a 25% downside risk, reflecting concerns about its future performance.
- Optimistic Outlook for Novavax: Novavax closed at $9.90, with analysts projecting a 12-month price target of $12.89, suggesting a 30% upside, indicating confidence in its growth potential.
- Significant Licensing Agreement: Novavax's non-exclusive licensing deal with Pfizer includes a $30 million upfront payment and up to $500 million in development and sales milestones, showcasing its strategic positioning in the vaccine market and potential future revenue.
- High Market Sentiment: On Stocktwits, retail sentiment for both Moderna and Novavax is ‘extremely bullish’, with Novavax's message activity surging over 600% in the past year, indicating strong investor confidence in its future performance.
See More
