Brepocitinib Shows Positive Phase 2 Results in Cutaneous Sarcoidosis
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Feb 06 2026
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Should l Buy ROIV?
Source: Newsfilter
- Clinical Trial Results: Brepocitinib 45 mg achieved a 22.3-point mean improvement in CSAMI-A for cutaneous sarcoidosis, compared to a 0.7-point improvement in placebo, demonstrating significant clinical efficacy with a P-value of less than 0.0001, marking a breakthrough in treatment.
- FDA Application Progress: Priovant has submitted an NDA for brepocitinib in dermatomyositis to the FDA, with plans to initiate a pivotal Phase 3 study for cutaneous sarcoidosis in 2026, further enhancing the drug's market potential.
- Strong Financial Position: As of December 31, 2025, Roivant reported $4.5 billion in cash and cash equivalents, supporting its research and development activities and ensuring stable cash flow ahead of profitability.
- Multiple Research Advancements: Roivant is actively exploring additional indications for brepocitinib, including non-infectious uveitis and difficult-to-treat rheumatoid arthritis, with topline data expected in the second half of 2026, further diversifying its product pipeline.
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Analyst Views on ROIV
Wall Street analysts forecast ROIV stock price to rise
8 Analyst Rating
7 Buy
1 Hold
0 Sell
Strong Buy
Current: 26.750
Low
22.00
Averages
27.63
High
33.00
Current: 26.750
Low
22.00
Averages
27.63
High
33.00
About ROIV
Roivant Sciences Ltd. is a biopharmaceutical company focused on improving the lives of patients by accelerating the development and commercialization of medicines that matter. The Company’s pipeline includes brepocitinib, a potent small molecule inhibitor of TYK2 and JAK1 in development for the treatment of dermatomyositis, non-infectious uveitis and cutaneous sarcoidosis; IMVT-1402 and batoclimab, fully human monoclonal antibodies targeting FcRn in development across several IgG-mediated autoimmune indications; and mosliciguat, an inhaled sGC activator in development for pulmonary hypertension associated with interstitial lung disease. It also incubates discovery-stage companies and health technology startups complementary to its biopharmaceutical business.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Citi and H.C. Wainwright Raise Roivant Sciences Price Targets Following Positive Drug Data
- Price Target Increases: Citi raised Roivant Sciences' price target from $26 to $35 while maintaining a Buy rating, primarily based on positive Phase 2 data for brepocitinib in cutaneous sarcoidosis, indicating strong growth potential for the drug.
- Impressive Data Performance: H.C. Wainwright also increased Roivant's price target from $26 to $33, emphasizing the impressive Phase 2 data and incorporating this indication into their valuation model, reflecting growing market confidence in the drug.
- Bank Rating Changes: Prior to this, Bank of America raised Roivant's price target from $22 to $26 with a Neutral rating, noting that FQ3 2026 results were in line with expectations and highlighting the positive topline results for brepocitinib.
- Optimistic Market Outlook: With analysts raising sales forecasts for brepocitinib, Roivant Sciences' market outlook is generally positive, showcasing the company's potential and investment value in the biopharmaceutical sector.
See More
Roivant Sciences (ROIV.US) Officer Plans to Sell $5.3 Million in Common Stock via Form 144
Stock Sale Announcement: Officer Venker Eric plans to sell 200,000 shares of its common stock on February 13, with an estimated market value of around $5.3 million.
Reduction in Shareholding: Venker Eric has decreased his shareholding in Roivant Sciences by 682,050 shares since November 20, 2025, totaling an approximate value of $14.88 million.
See More
Top Performing Large-Cap Stocks Last Week
- Lumentum Earnings Beat: Lumentum Holdings Inc. surged 36.02% this week after reporting second-quarter results that exceeded expectations and providing third-quarter guidance above analyst estimates, thereby boosting investor confidence and significantly driving up the stock price.
- Transportation Stocks Rally: Saia, Inc. jumped 23.07% this week, benefiting from declining oil prices, which led to a strong performance across the transportation sector, indicating optimistic market expectations for transportation demand that could enhance future earnings.
- Westlake Stock Increase: Westlake Corporation saw a 19.27% rise in its stock price this week, reflecting positive market sentiment regarding its business outlook, particularly in the context of declining raw material costs that may improve profitability.
- Market Recovery: The strong performance of these stocks indicates a growing investor confidence in economic recovery, especially amid falling oil prices, which could further drive growth in related industries.
See More
Roivant Sciences Q3 2025 Earnings Call Highlights
- Clinical Trial Progress: Roivant reported positive Phase II results for brepocitinib in cutaneous sarcoidosis, with 100% of patients showing a clinically meaningful 10-point improvement, which is expected to drive future commercialization efforts.
- Financial Performance: The company reported R&D expenses of $165 million for the third quarter, with an adjusted non-GAAP net loss of $167 million; however, cash reserves remain strong at $4.5 billion, providing ample funding for future R&D.
- Future Outlook: Management anticipates that 2026 will be a pivotal year, with multiple clinical trials for brepo expected to conclude in the second half of the year, particularly the Phase III study for cutaneous sarcoidosis, potentially opening new market opportunities.
- Legal Risks: Roivant faces a jury trial against Moderna starting on March 9, raising concerns about legal risks that could impact the company's operations and market performance.
See More
U.S. Markets Increased on Friday; Strategy Reached New Heights
U.S. Stock Market Performance: U.S. stock indexes experienced significant gains on Friday, with the overall market climbing by 2.47%.
Individual Index Gains: The S&P 500 index rose by 2.18%, while the Dow Jones Industrial Average saw an increase of 1.97%.
See More
Roivant Sciences Stock Soars on Positive Phase 2 Results for Brepocitinib
- Clinical Trial Success: Roivant Sciences' BEACON study involving 31 patients demonstrated that the 45 mg brepocitinib group achieved a 100% response rate across multiple endpoints, significantly outperforming the placebo group, indicating the drug's potential in treating cutaneous sarcoidosis.
- Significant Improvement Metrics: On the Cutaneous Sarcoidosis Activity and Morphology Instrument (CSAMI-A), patients in the 45 mg group showed a mean improvement of 22.3 points at Week 16 compared to just 0.7 points in the placebo group, with statistical significance observed as early as Week 4, highlighting the drug's rapid efficacy.
- Future Research Plans: Roivant's subsidiary Priovant plans to initiate a Phase 3 clinical trial for brepocitinib in 2026, further validating its effectiveness in treating cutaneous sarcoidosis, marking a critical step in the drug's clinical development.
- Improved Financial Performance: Roivant reported an adjusted loss of 24 cents per share, better than the consensus estimate of 32 cents, with sales around $2 million, indicating financial improvement and a cash reserve of $4.5 billion supporting future profitability.
See More
Citi and H.C. Wainwright Raise Roivant Sciences Price Targets Following Positive Drug Data
- Price Target Increases: Citi raised Roivant Sciences' price target from $26 to $35 while maintaining a Buy rating, primarily based on positive Phase 2 data for brepocitinib in cutaneous sarcoidosis, indicating strong growth potential for the drug.
- Impressive Data Performance: H.C. Wainwright also increased Roivant's price target from $26 to $33, emphasizing the impressive Phase 2 data and incorporating this indication into their valuation model, reflecting growing market confidence in the drug.
- Bank Rating Changes: Prior to this, Bank of America raised Roivant's price target from $22 to $26 with a Neutral rating, noting that FQ3 2026 results were in line with expectations and highlighting the positive topline results for brepocitinib.
- Optimistic Market Outlook: With analysts raising sales forecasts for brepocitinib, Roivant Sciences' market outlook is generally positive, showcasing the company's potential and investment value in the biopharmaceutical sector.
See More
Roivant Sciences (ROIV.US) Officer Plans to Sell $5.3 Million in Common Stock via Form 144
Stock Sale Announcement: Officer Venker Eric plans to sell 200,000 shares of its common stock on February 13, with an estimated market value of around $5.3 million.
Reduction in Shareholding: Venker Eric has decreased his shareholding in Roivant Sciences by 682,050 shares since November 20, 2025, totaling an approximate value of $14.88 million.
See More
Top Performing Large-Cap Stocks Last Week
- Lumentum Earnings Beat: Lumentum Holdings Inc. surged 36.02% this week after reporting second-quarter results that exceeded expectations and providing third-quarter guidance above analyst estimates, thereby boosting investor confidence and significantly driving up the stock price.
- Transportation Stocks Rally: Saia, Inc. jumped 23.07% this week, benefiting from declining oil prices, which led to a strong performance across the transportation sector, indicating optimistic market expectations for transportation demand that could enhance future earnings.
- Westlake Stock Increase: Westlake Corporation saw a 19.27% rise in its stock price this week, reflecting positive market sentiment regarding its business outlook, particularly in the context of declining raw material costs that may improve profitability.
- Market Recovery: The strong performance of these stocks indicates a growing investor confidence in economic recovery, especially amid falling oil prices, which could further drive growth in related industries.
See More
Roivant Sciences Q3 2025 Earnings Call Highlights
- Clinical Trial Progress: Roivant reported positive Phase II results for brepocitinib in cutaneous sarcoidosis, with 100% of patients showing a clinically meaningful 10-point improvement, which is expected to drive future commercialization efforts.
- Financial Performance: The company reported R&D expenses of $165 million for the third quarter, with an adjusted non-GAAP net loss of $167 million; however, cash reserves remain strong at $4.5 billion, providing ample funding for future R&D.
- Future Outlook: Management anticipates that 2026 will be a pivotal year, with multiple clinical trials for brepo expected to conclude in the second half of the year, particularly the Phase III study for cutaneous sarcoidosis, potentially opening new market opportunities.
- Legal Risks: Roivant faces a jury trial against Moderna starting on March 9, raising concerns about legal risks that could impact the company's operations and market performance.
See More
U.S. Markets Increased on Friday; Strategy Reached New Heights
U.S. Stock Market Performance: U.S. stock indexes experienced significant gains on Friday, with the overall market climbing by 2.47%.
Individual Index Gains: The S&P 500 index rose by 2.18%, while the Dow Jones Industrial Average saw an increase of 1.97%.
See More
Roivant Sciences Stock Soars on Positive Phase 2 Results for Brepocitinib
- Clinical Trial Success: Roivant Sciences' BEACON study involving 31 patients demonstrated that the 45 mg brepocitinib group achieved a 100% response rate across multiple endpoints, significantly outperforming the placebo group, indicating the drug's potential in treating cutaneous sarcoidosis.
- Significant Improvement Metrics: On the Cutaneous Sarcoidosis Activity and Morphology Instrument (CSAMI-A), patients in the 45 mg group showed a mean improvement of 22.3 points at Week 16 compared to just 0.7 points in the placebo group, with statistical significance observed as early as Week 4, highlighting the drug's rapid efficacy.
- Future Research Plans: Roivant's subsidiary Priovant plans to initiate a Phase 3 clinical trial for brepocitinib in 2026, further validating its effectiveness in treating cutaneous sarcoidosis, marking a critical step in the drug's clinical development.
- Improved Financial Performance: Roivant reported an adjusted loss of 24 cents per share, better than the consensus estimate of 32 cents, with sales around $2 million, indicating financial improvement and a cash reserve of $4.5 billion supporting future profitability.
See More
