MCRB Overview

FDA Feedback on SER-155: Seres Therapeutics received constructive feedback from the FDA regarding the Phase 2 study protocol for SER-155, aimed at preventing bloodstream infections in adults undergoing stem cell transplants, which will aid in finalizing the protocol.

Workforce Reduction and Financial Outlook: The company is reducing its workforce by approximately 25%, which is expected to incur cash payments of $1.0 - $1.4 million in Q4 2025, while extending its cash runway into the second quarter of 2026.

Cost-Cutting Measures: Seres Therapeutics plans to reduce its workforce by about 25% to trim operating costs, which is expected to extend its cash runway into the second quarter of 2026.

SER-155 Study Development: Following positive FDA feedback, the company aims to finalize the Phase 2 study protocol for SER-155, targeting bloodstream infections in adults undergoing stem cell transplants, while seeking capital to support this and other biotherapeutic developments.

Zacks Rank Upgrade: Seres Therapeutics (MCRB) has been upgraded to a Zacks Rank #2 (Buy) due to a significant increase in earnings estimates, indicating a positive outlook for the company's stock price.

Earnings Estimate Revisions: The Zacks rating system, which correlates earnings estimate revisions with stock price movements, suggests that Seres Therapeutics is positioned for potential near-term gains, as it falls within the top 20% of Zacks-covered stocks based on these revisions.

Biotech Stocks Surge: Several biotech and medical technology stocks experienced significant gains in after-hours trading, driven by earnings optimism, clinical trial progress, and speculative positioning, with notable movers including Seres Therapeutics and TransMedics.

Key Developments: TransMedics received FDA approval for its heart trial, while Capricor announced a milestone in its vaccine trial. Other companies like Karyopharm and Coya Therapeutics saw stock rebounds despite lacking specific news catalysts, indicating investor anticipation for future developments.

Market Volatility: Stocks such as Meihua International and Jin Medical showed notable price movements without specific news, reflecting technical rebounds and investor positioning in a volatile market environment.

Earnings Reports and Guidance: TransMedics raised its revenue guidance for 2025, projecting significant growth, while other companies are preparing for upcoming earnings reports and trial milestones, contributing to the overall market momentum in the biotech sector.

Robinhood's Market Movement: Robinhood Markets, Inc. shares surged 7.4% in pre-market trading after being announced as a replacement for Caesars Entertainment in the S&P 500, effective September 22.

Other Notable Gainers: Several stocks saw significant pre-market gains, including Eightco Holdings (up 142.1%), Gyrodyne (up 82.1%), and Forward Industries (up 78.8%).

Pre-Market Losers: Citius Oncology experienced a 25% drop, while MEI Pharma and CNFinance also saw declines of 19.3% and 18.8%, respectively, in pre-market trading.

Market Overview: The article provides a snapshot of various stocks' performances, highlighting both significant gainers and losers in the pre-market trading session.