Neutral/Negative Catalysts
- Development-stage biotech risk: KRRO-121 is still preclinical/early clinical pathway; execution and translation risk remain high.
- Overhang from prior program failure: KRRO-110 failure (delivery/LNP issues) can keep skepticism elevated even with a “reset” narrative.
- High implied volatility (154%): market expects large swings; price can gap around any update.
- Cash burn profile: ongoing losses (no durable operating profitability indicated by latest quarter).
- No politician/congress signal: no recent congress trading data available; insiders noted as neutral (no supportive buying trend).