Vicarious Surgical Completes In-Vivo Lab in December 2025, Advancing Robotic Surgery System Development
- Successful Lab Testing: Vicarious Surgical completed an in-vivo lab with porcine models in December 2025, marking a significant advancement in the development of its robotic surgery system, which is expected to facilitate a design freeze by the end of 2026.
- Key Procedure Evaluation: During the lab, surgeons independently performed critical elements of a ventral hernia repair, validating the feasibility of the pre-DV system and providing essential data for future design decisions.
- System Performance Assessment: The lab included three independent development protocols that evaluated core system capabilities such as instrument articulation, visualization, and system integration in a realistic surgical environment, ensuring minimized technical risks.
- Data-Driven Optimization: The data generated and surgeon feedback from the lab will be incorporated into ongoing design refinement and verification planning, further advancing Vicarious Surgical's innovations in minimally invasive surgery.
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- Successful Lab Testing: Vicarious Surgical completed an in-vivo lab with porcine models in December 2025, marking a significant advancement in the development of its robotic surgery system, which is expected to facilitate a design freeze by the end of 2026.
- Key Procedure Evaluation: During the lab, surgeons independently performed critical elements of a ventral hernia repair, validating the feasibility of the pre-DV system and providing essential data for future design decisions.
- System Performance Assessment: The lab included three independent development protocols that evaluated core system capabilities such as instrument articulation, visualization, and system integration in a realistic surgical environment, ensuring minimized technical risks.
- Data-Driven Optimization: The data generated and surgeon feedback from the lab will be incorporated into ongoing design refinement and verification planning, further advancing Vicarious Surgical's innovations in minimally invasive surgery.
- Significant Stock Surge: GH Research PLC shares rose 18.1% to $15.64 in pre-market trading, reflecting strong market anticipation for the upcoming update on its FDA IND status and Phase 3 program for GH001, which could pave the way for future drug approvals.
- Positive Market Reaction: As the company prepares to update its treatment plan for treatment-resistant depression, investor confidence in GH Research's prospects has significantly increased, potentially attracting more investors and enhancing the company's market valuation.
- Industry-Wide Impact: The progress of GH Research may not only boost its own stock price but also positively influence the entire biopharmaceutical sector, particularly in the treatment-resistant depression space, encouraging other companies to increase their R&D investments.
- Optimistic Future Outlook: With the FDA update on the horizon, GH Research is poised to gather more clinical data in the coming months, which will provide crucial support for its subsequent marketing and commercialization strategies, strengthening its position in the competitive pharmaceutical market.

- Strategic Partnership Agreement: Vicarious Surgical has entered into a partnership with a global digital engineering firm to reduce operating costs and enhance development predictability and execution efficiency through a more effective mix of internal and external engineering resources.
- Software Development Outsourcing: Under the agreement, the external partner will take on significant software development responsibilities for the Vicarious Surgical robotic system, including control systems and visualization components, which is expected to accelerate development speed and lower structural costs.
- Operational Model Transformation: This collaboration allows internal teams to focus on core innovation and system integration, thereby improving the company's progress toward design freeze and clinical readiness while optimizing its cost structure.
- Ongoing Transition Plan: The external engineering partner has begun onboarding through a structured transition plan that maintains continuity across all active workstreams, supporting the company's predictable progress toward key milestones.

- Strategic Partnership: Vicarious Surgical has entered into a strategic partnership with a global digital engineering firm, aiming to lower operating costs through an efficient mix of internal and external engineering resources, which is expected to significantly improve the company's cash burn guidance.
- Software Development Outsourcing: Under the agreement, the external partner will take on key software development responsibilities for the Vicarious Surgical robotic system, including control systems and visualization components, thereby enhancing development velocity and milestone predictability.
- Operational Model Transformation: This partnership is a central component of the company's broader operational model transformation, designed to improve execution efficiency and streamline development pathways, which is expected to support more predictable progress.
- Focus on Core Innovation: By partnering with an organization experienced in managing similar complex projects, Vicarious Surgical can concentrate its internal teams on core innovation and system integration, accelerating the timeline toward design freeze and clinical readiness.

UiPath Financial Results: UiPath Inc. shares rose 8.7% in pre-market trading after reporting third-quarter adjusted earnings of 16 cents per share and revenue of $411.11 million, both exceeding estimates.
Other Gainers: Several stocks saw significant pre-market gains, including Polyrizon Ltd (+158.1%), Nauticus Robotics, Inc (+34%), and Picard Medical, Inc (+22.3%), driven by positive news and developments.
Notable Losers: Virax Biolabs Group Ltd fell 16.2% after announcing a private placement, while Treasure Global Inc declined 13.3% following a reverse stock split and Nasdaq delisting notification.
Market Overview: The pre-market trading session showed a mix of gains and losses across various stocks, with some companies like Axogen, Inc and Hyster-Yale, Inc also experiencing notable increases.
- Cash Burn Guidance Update: Vicarious Surgical has improved its 2025 cash burn forecast from $50 million to $45 million, reflecting ongoing cost management efforts aimed at enhancing financial health and operational efficiency.
- Future Outlook: The company plans to provide guidance for 2026 cash burn before year-end, indicating that its ongoing operational reset will further optimize resource allocation to support long-term strategic goals.
- Leadership Changes: The Board has appointed Victoria Carr-Brendel as Chair of the Compensation Committee, with Fuad Ahmad and Joseph Doherty joining the Compensation and Audit Committees respectively, aimed at strengthening corporate governance and decision-making efficiency.
- Technological Innovation Context: Vicarious Surgical focuses on developing human-like surgical robots to enhance surgical efficiency and improve patient outcomes, which is expected to lower healthcare costs and enhance market competitiveness through technological breakthroughs.







