Upcoming Stock Splits This Week (June 2 to June 6) – Stay Invested
Upcoming Stock Splits: Several companies, including ARB IOT Group, Lyell Immunopharma, and Mullen Automotive, are implementing reverse stock splits to comply with Nasdaq listing requirements, effective from June 2 to June 3.
Purpose of Stock Splits: Stock splits, whether traditional or reverse, aim to adjust share prices for market compliance or to attract investors, while maintaining the overall market value of the company.
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Analyst Views on LYEL
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- Outstanding Stock Performance: Mineralys Therapeutics has seen its stock price soar by 203.4% in 2025, reflecting strong market confidence in its product candidate lorundrostat, which is expected to drive further growth in 2026.
- Successful Clinical Trials: In the first half of 2025, the pivotal Phase III Launch-HTN and Phase II Advance-HTN studies for lorundrostat met their primary efficacy endpoints, indicating its potential as a best-in-class treatment for resistant hypertension, which could significantly enhance the company's market position.
- NDA Submission Preparation: The company is gearing up to submit a New Drug Application (NDA) for lorundrostat in early 2026, paving the way for market entry and potentially boosting revenue and market share significantly.
- Multiple Research Advancements: Mineralys has also completed enrollment in the Phase II Explore-OSA study for lorundrostat in overweight and obese patients with moderate-to-severe OSA, with top-line data expected in Q1 2026, further strengthening its competitive edge in the market.

- Market Potential: The U.S. oncology market is projected to surge from $81 billion in 2025 to $212 billion by 2034, reflecting the rapid rise of precision therapies and immunotherapies, enhancing the investment outlook for companies like GT Biopharma.
- Clinical Trial Progress: GT Biopharma has advanced its GTB-3650 clinical trial to Cohort 4, where patients receive a dosing of 10μg/kg/day, indicating potential efficacy in treating resistant blood cancers and providing new treatment options for patients.
- Safety Confirmation: Six patients enrolled in Cohorts 1, 2, and 3 have successfully completed GTB-3650 treatment, establishing its safety profile with no dose-limiting toxicities observed across all completed cohorts, thereby boosting confidence in the clinical trial.
- Future Outlook: GT Biopharma plans to share its next trial update in Q1 2026, with expectations to continue assessing higher doses for efficacy, further driving innovation in the field of tumor immunotherapy.
Positive Market Reaction: Lyell Immunopharma's stock rose approximately 17% following the presentation of promising data on its CAR-T therapy for blood cancer at the American Society of Hematology Annual Meeting.
Encouraging CAR-T Therapy Results: New data revealed that the CAR-T therapy rondecabtagene autoleucel achieved an 83% overall response rate and a 61% complete response rate in patients with large B-cell lymphoma, with 70% of those who responded completely maintaining their response for six months or longer.
Strategic Acquisition: In November, Lyell acquired the rights to LYL273, a CAR-T treatment for metastatic colorectal cancer, enhancing its portfolio in the CAR-T therapy space.
Market Growth Projection: ResearchAndMarkets.com forecasts that the CAR-T therapy market will expand significantly, growing from $3.87 billion in 2024 to $13.25 billion by 2030.
- FDA Approval Milestone: The FDA's November 2025 approval of the first bispecific antibody combination for second-line blood cancer treatment marks a significant shift from traditional chemotherapy, likely enhancing market share for companies like GT Biopharma.
- Clinical Trial Advancement: GT Biopharma has advanced its GTB-3650 clinical trial to Cohort 4, where patients receive a 10μg/kg/day dose, demonstrating a favorable safety profile and potential clinical efficacy, which could provide new options for patients with refractory blood cancers.
- Expansive Market Outlook: The CAR-T cell therapy market is projected to surge from $3.87 billion in 2024 to $13.25 billion by 2030, positioning GT Biopharma's innovative therapies to capture a significant share in this rapidly growing market.
- Future Plans: GT Biopharma plans to share its next clinical trial update in Q1 2026, continuing the dose escalation study of GTB-3650, which is expected to further validate its efficacy and expand patient benefit opportunities.

- FDA Approval Milestone: The FDA's November approval of the first bispecific antibody combination for second-line blood cancer treatment marks a significant shift from traditional chemotherapy, which is expected to enhance market performance for companies like GT Biopharma.
- Clinical Trial Advancement: GT Biopharma has advanced its GTB-3650 clinical trial to Cohort 4, where patients are receiving a dosing of 10μg/kg/day, indicating potential efficacy in patients with relapsed blood cancers, which could open new market opportunities for the company.
- Safety Validation: Six patients enrolled in Cohorts 1, 2, and 3 have successfully completed GTB-3650 treatment, establishing the therapy's safety profile across escalating doses, laying the groundwork for subsequent trials at higher doses.
- Future Outlook: The company anticipates sharing the next trial update in Q1 2026, and as dosing increases, clinical efficacy is expected to improve further, potentially attracting more investor interest.









