The Short List: Current Top 10 Most Shorted Stocks
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 26 2025
0mins
Should l Buy NTLA?
Source: Benzinga
Reasons for Short Selling: Traders short stocks to either bet on a decline in value or to profit from potential short squeezes, where rising prices force short sellers to buy back shares, creating a feedback loop of increasing demand.
Characteristics of Heavily Shorted Stocks: Stocks become heavily shorted when experienced traders believe they are overvalued, indicating serious risks, while retail traders may see high short interest as an opportunity for quick gains.
Top Heavily Shorted Stocks: As of November 26, 2025, the most shorted stocks include The Wendy's Co. (WEN) at 55.36% short interest, followed by Cambium Networks Corp. (CMBM) and Lucid Group, Inc. (LCID).
Risks and Volatility: While short squeezes can lead to significant gains, they come with high risks and volatility, necessitating careful monitoring and due diligence by traders.
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Analyst Views on NTLA
Wall Street analysts forecast NTLA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NTLA is 16.50 USD with a low forecast of 4.00 USD and a high forecast of 54.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
22 Analyst Rating
9 Buy
12 Hold
1 Sell
Moderate Buy
Current: 11.090
Low
4.00
Averages
16.50
High
54.00
Current: 11.090
Low
4.00
Averages
16.50
High
54.00
About NTLA
Intellia Therapeutics, Inc. is a clinical-stage gene editing company focused on developing medicine with CRISPR-based therapies. CRISPR is a gene editing technology which is also sometimes referred to as CRISPR/Cas or CRISPR/Cas9 when referring to the use of CRISPR technology with the Cas9 enzyme. Its in vivo product candidates address genetic diseases by deploying its technologies, including CRISPR/Cas9 delivered by LNPs, as the therapy for diseases with high unmet need. Its lead in vivo product candidates, nexiguran ziclumeran (nex-z or NTLA-2001) for the treatment of transthyretin (ATTR) amyloidosis and NTLA-2002 for the treatment of hereditary angioedema (HAE), are the first CRISPR-based therapy candidates to be administered systemically, via intravenous (IV) infusion, for precision editing of a gene in a target tissue in humans. For its ex vivo product candidates, it applies its technologies to create engineered cell therapies to address immuno-oncology and autoimmune diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Analysis of Intellia Therapeutics' Stock Recovery
- Stock Recovery Reasons: Intellia Therapeutics' stock surged 10.73% following the FDA's lifting of the clinical hold on nex-z, indicating a restoration of market confidence after regulatory setbacks, which is expected to enhance its future investment appeal.
- Significant Market Potential: Nex-z targets transthyretin amyloidosis, affecting 50,000 patients globally, while the HAE market is projected to reach $6.3 billion by 2030, showcasing Intellia's vast market opportunities in rare disease treatments.
- Ongoing Clinical Risks: Despite the lifting of the clinical hold on nex-z, Intellia still faces regulatory challenges with other studies, particularly with lonvo-z, which could impact stock price stability and investor confidence.
- Investment Risk Advisory: Given the complexity and high costs associated with gene editing medicines, Intellia's stock remains a high-risk investment, suggesting that investors with lower risk tolerance should approach with caution.
See More
Intellia Therapeutics Regulatory Progress and Market Potential
- Regulatory Progress: Intellia Therapeutics' stock has risen 41% following the FDA's lifting of the clinical hold on nex-z, indicating market confidence in its potential treatment, although another study remains on hold, necessitating caution from investors.
- Market Opportunity: Intellia estimates that the HAE market will reach $6.3 billion by 2030, while the transthyretin amyloidosis market could hit $16.8 billion, highlighting significant market potential in rare diseases despite facing clinical and regulatory hurdles.
- Investment Risks: Even with the potential launch of nex-z and lonvo-z, the complexity and high costs associated with gene editing medicines may limit their market performance, prompting investors to weigh these risks, particularly in clinical-stage biotech investments.
- Industry Competition: Intellia's exclusion from The Motley Fool Stock Advisor's list of the top 10 stocks reflects a cautious market outlook on its future performance, suggesting that investors should consider more promising investment opportunities.
See More
FDA Lifts Clinical Hold on Intellia's IND for ATTRv-PN Trial
- Clinical Hold Lifted: The FDA lifted the clinical hold on Intellia Therapeutics' MAGNITUDE-2 Phase 3 trial, allowing the company to proceed with its investigational new drug application for hereditary transthyretin amyloidosis (ATTRv-PN), which is expected to positively impact future R&D progress.
- Increased Enrollment Target: Intellia has raised the target enrollment for the MAGNITUDE-2 trial from approximately 50 to 60 patients, aiming to enhance the reliability of study results and bolster market confidence in its treatment approach.
- Positive Efficacy Data: In the ongoing Phase 1 study, patients receiving a one-time dose of 0.3 mg/kg or higher (n=33) showed a 92% mean reduction in serum TTR levels at 24 months, indicating the long-term efficacy of nexiguran ziclumeran, which may boost investor confidence in Intellia.
- Enhanced Safety Monitoring: Intellia has agreed with the FDA to implement enhanced safety monitoring measures for liver laboratory tests in the MAGNITUDE-2 trial, addressing previous safety events and providing stronger safety assurances for future clinical trials.
See More
FDA Lifts Clinical Hold on Intellia's Phase 3 Trial
- Clinical Trial Advancement: The FDA has lifted the clinical hold on Intellia's Phase 3 trial for a rare nerve disease following safety updates, marking a significant breakthrough in the company's critical R&D phase and potentially accelerating the path to market.
- Heart Disease Program Review: While the FDA has removed the hold on the Phase 3 trial, the review of Intellia's heart disease program continues, which may impact the company's market entry timeline and strategic positioning in the cardiovascular sector.
- Safety Update Impact: Intellia's safety updates have been recognized by the FDA, indicating effective measures taken to ensure patient safety during trials, which not only boosts investor confidence but may also attract more partners to its R&D initiatives.
- Market Reaction Expectations: With the FDA's positive developments, Intellia's stock price is likely to experience a favorable impact, as investors are optimistic about its future commercial potential and market performance, especially in the competitive landscape of rare disease treatments.
See More
FDA Lifts Clinical Hold on Nex-Z Trial for ATTRv-PN
- Trial Resumption: The FDA lifted the clinical hold on Intellia Therapeutics' Nexiguran Ziclumeran (Nex-Z) MAGNITUDE-2 Phase 3 trial, allowing the company to resume patient enrollment, which is expected to accelerate treatment progress for the rare nerve-damaging disease ATTRv-PN.
- Increased Enrollment Target: Following a protocol update, Intellia raised the target enrollment for MAGNITUDE-2 to approximately 60 patients, aiming to enhance the statistical power of the study and expedite the validation of the treatment option.
- Positive Market Reaction: Shares of Intellia surged over 13% after the FDA lifted the clinical hold, reflecting strong investor confidence in the potential efficacy of Nex-Z and optimistic expectations for the company's future growth.
- Retail Sentiment Shift: Retail sentiment on Stocktwits shifted from 'bullish' to 'extremely bullish' following the news, accompanied by high message volumes, indicating strong investor enthusiasm for the therapy's market prospects, with expectations for the stock to surpass $20 by the end of the trading session.
See More
HCA Healthcare Surges After Strong Q4 Earnings and Upgraded FY25 Guidance
- Earnings Beat: HCA Healthcare reported an adjusted EPS of $8.01 for Q4, surpassing the analyst consensus of $7.43, indicating robust profitability and strong market demand.
- Stock Surge: Following the earnings report, HCA's shares jumped 9.5% to $517.00 on Tuesday, reflecting investor confidence in the company's future growth prospects.
- Upgraded Guidance: The company raised its FY25 guidance above estimates, signaling a positive outlook for business development that may attract more investor interest.
- Positive Market Reaction: HCA's favorable news boosted overall market confidence in the healthcare sector, potentially leading to further gains in related stocks.
See More
Analysis of Intellia Therapeutics' Stock Recovery
- Stock Recovery Reasons: Intellia Therapeutics' stock surged 10.73% following the FDA's lifting of the clinical hold on nex-z, indicating a restoration of market confidence after regulatory setbacks, which is expected to enhance its future investment appeal.
- Significant Market Potential: Nex-z targets transthyretin amyloidosis, affecting 50,000 patients globally, while the HAE market is projected to reach $6.3 billion by 2030, showcasing Intellia's vast market opportunities in rare disease treatments.
- Ongoing Clinical Risks: Despite the lifting of the clinical hold on nex-z, Intellia still faces regulatory challenges with other studies, particularly with lonvo-z, which could impact stock price stability and investor confidence.
- Investment Risk Advisory: Given the complexity and high costs associated with gene editing medicines, Intellia's stock remains a high-risk investment, suggesting that investors with lower risk tolerance should approach with caution.
See More
Intellia Therapeutics Regulatory Progress and Market Potential
- Regulatory Progress: Intellia Therapeutics' stock has risen 41% following the FDA's lifting of the clinical hold on nex-z, indicating market confidence in its potential treatment, although another study remains on hold, necessitating caution from investors.
- Market Opportunity: Intellia estimates that the HAE market will reach $6.3 billion by 2030, while the transthyretin amyloidosis market could hit $16.8 billion, highlighting significant market potential in rare diseases despite facing clinical and regulatory hurdles.
- Investment Risks: Even with the potential launch of nex-z and lonvo-z, the complexity and high costs associated with gene editing medicines may limit their market performance, prompting investors to weigh these risks, particularly in clinical-stage biotech investments.
- Industry Competition: Intellia's exclusion from The Motley Fool Stock Advisor's list of the top 10 stocks reflects a cautious market outlook on its future performance, suggesting that investors should consider more promising investment opportunities.
See More
FDA Lifts Clinical Hold on Intellia's IND for ATTRv-PN Trial
- Clinical Hold Lifted: The FDA lifted the clinical hold on Intellia Therapeutics' MAGNITUDE-2 Phase 3 trial, allowing the company to proceed with its investigational new drug application for hereditary transthyretin amyloidosis (ATTRv-PN), which is expected to positively impact future R&D progress.
- Increased Enrollment Target: Intellia has raised the target enrollment for the MAGNITUDE-2 trial from approximately 50 to 60 patients, aiming to enhance the reliability of study results and bolster market confidence in its treatment approach.
- Positive Efficacy Data: In the ongoing Phase 1 study, patients receiving a one-time dose of 0.3 mg/kg or higher (n=33) showed a 92% mean reduction in serum TTR levels at 24 months, indicating the long-term efficacy of nexiguran ziclumeran, which may boost investor confidence in Intellia.
- Enhanced Safety Monitoring: Intellia has agreed with the FDA to implement enhanced safety monitoring measures for liver laboratory tests in the MAGNITUDE-2 trial, addressing previous safety events and providing stronger safety assurances for future clinical trials.
See More
FDA Lifts Clinical Hold on Intellia's Phase 3 Trial
- Clinical Trial Advancement: The FDA has lifted the clinical hold on Intellia's Phase 3 trial for a rare nerve disease following safety updates, marking a significant breakthrough in the company's critical R&D phase and potentially accelerating the path to market.
- Heart Disease Program Review: While the FDA has removed the hold on the Phase 3 trial, the review of Intellia's heart disease program continues, which may impact the company's market entry timeline and strategic positioning in the cardiovascular sector.
- Safety Update Impact: Intellia's safety updates have been recognized by the FDA, indicating effective measures taken to ensure patient safety during trials, which not only boosts investor confidence but may also attract more partners to its R&D initiatives.
- Market Reaction Expectations: With the FDA's positive developments, Intellia's stock price is likely to experience a favorable impact, as investors are optimistic about its future commercial potential and market performance, especially in the competitive landscape of rare disease treatments.
See More
FDA Lifts Clinical Hold on Nex-Z Trial for ATTRv-PN
- Trial Resumption: The FDA lifted the clinical hold on Intellia Therapeutics' Nexiguran Ziclumeran (Nex-Z) MAGNITUDE-2 Phase 3 trial, allowing the company to resume patient enrollment, which is expected to accelerate treatment progress for the rare nerve-damaging disease ATTRv-PN.
- Increased Enrollment Target: Following a protocol update, Intellia raised the target enrollment for MAGNITUDE-2 to approximately 60 patients, aiming to enhance the statistical power of the study and expedite the validation of the treatment option.
- Positive Market Reaction: Shares of Intellia surged over 13% after the FDA lifted the clinical hold, reflecting strong investor confidence in the potential efficacy of Nex-Z and optimistic expectations for the company's future growth.
- Retail Sentiment Shift: Retail sentiment on Stocktwits shifted from 'bullish' to 'extremely bullish' following the news, accompanied by high message volumes, indicating strong investor enthusiasm for the therapy's market prospects, with expectations for the stock to surpass $20 by the end of the trading session.
See More
HCA Healthcare Surges After Strong Q4 Earnings and Upgraded FY25 Guidance
- Earnings Beat: HCA Healthcare reported an adjusted EPS of $8.01 for Q4, surpassing the analyst consensus of $7.43, indicating robust profitability and strong market demand.
- Stock Surge: Following the earnings report, HCA's shares jumped 9.5% to $517.00 on Tuesday, reflecting investor confidence in the company's future growth prospects.
- Upgraded Guidance: The company raised its FY25 guidance above estimates, signaling a positive outlook for business development that may attract more investor interest.
- Positive Market Reaction: HCA's favorable news boosted overall market confidence in the healthcare sector, potentially leading to further gains in related stocks.
See More
