Taltz and Zepbound Combination Therapy Significantly Outperforms Monotherapy
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 1 hour ago
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Should l Buy LLY?
Source: PRnewswire
- Clinical Trial Results: In the TOGETHER-PsO study, the combination of Taltz and Zepbound achieved complete skin clearance (PASI 100) and ≥10% weight loss in 27.1% of patients at 36 weeks, significantly higher than the 5.8% in the Taltz monotherapy group (p<0.001), indicating the importance of combination therapy in improving patient quality of life.
- Significant Relative Advantage: Patients in the combination therapy group were 40% more likely to achieve PASI 100 compared to those on monotherapy, with rates of 40.6% versus 29.0% (p<0.05), demonstrating the positive impact of obesity treatment on psoriasis and providing new directions for future treatment strategies.
- High BMI Patient Population: The average BMI of study participants exceeded 39 kg/m², highlighting the high disease burden in this group and emphasizing the need for comprehensive treatment approaches for obesity and psoriasis, which could change clinical practice standards.
- Good Safety Profile: Adverse events in the combination therapy were generally mild to moderate, primarily including nausea, diarrhea, and injection site reactions, consistent with known safety profiles, indicating the feasibility and safety of this treatment regimen in clinical applications.
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Analyst Views on LLY
Wall Street analysts forecast LLY stock price to rise
20 Analyst Rating
18 Buy
2 Hold
0 Sell
Strong Buy
Current: 1040.000
Low
950.00
Averages
1192
High
1500
Current: 1040.000
Low
950.00
Averages
1192
High
1500
About LLY
Eli Lilly and Company is a medicine company, which discovers, develops, manufactures, markets, and sells pharmaceutical products worldwide. Its cardiometabolic health products include Basaglar; Humalog, Humalog Mix 75/25, Humalog U-100, Humalog U-200, Humalog Mix 50/50, insulin lispro, and others; Humulin, Humulin 70/30, and others; Jardiance; Mounjaro; Trulicity; Zepbound; VERVE-102; VERVE-201, and VERVE-301. Its oncology products include Cyramza, Erbitux, Tyvyt, and Verzenio. Its immunology products include Ebglyss, Olumiant, Omvoh, and Taltz. Its neuroscience products include Emgality and Kisunla. The Company is also engaged in radiopharmaceutical discovery, development, and manufacturing efforts, and clinical and pre-clinical radioligand therapies in development for the treatment of cancer. It is also developing an oral small molecule inhibitor of a4b7 integrin for inflammatory bowel disease (IBD). It is evaluating its novel gene therapy candidate, ixoberogene soroparvovec.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Eli Lilly's Innovation and Growth Prospects
- Strong Clinical Execution: Eli Lilly achieved positive outcomes in nearly all R&D key events in 2025, showcasing exceptional performance in diabetes and weight loss medications, which is expected to further drive market share and revenue growth in the future.
- Cancer Drug Progress: The company's cancer medication, Jaypirca, excelled in a phase 3 trial and is on track for label expansions, which will provide new revenue streams and enhance its competitiveness in oncology treatment.
- AI Investment: Eli Lilly is investing in building the industry's largest AI supercomputer to accelerate drug development, which is expected to significantly improve clinical trial success rates and bolster the company's innovative standing and market leadership in the pharmaceutical sector.
- Robust Financial Performance: The company continues to report strong financial results, boasts a rich product pipeline, and rewards shareholders through increasing dividends and share buybacks, demonstrating its diversified growth potential beyond diabetes and weight loss markets.
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- Survival Trends Favorable: Although overall survival results were immature at the time of analysis, preliminary data showed a favorable trend for Retevmo, highlighting its importance in early treatment and potentially encouraging more patients to undergo genomic testing for optimized therapy.
- Patient Recruitment: The LIBRETTO-432 trial enrolled 151 patients randomized 1:1 to receive either Retevmo or placebo, ensuring the reliability and clinical applicability of the results, further validating the use of targeted therapies in lung cancer.
- Future Outlook: Eli Lilly plans to present detailed trial results at an upcoming medical congress and submit data to global health authorities, which is expected to accelerate the adoption of targeted therapies in early-stage NSCLC patients and promote the widespread use of genomic testing.
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Immaturity of Analysis: The findings are considered immature due to the limited number of events observed during the analysis period.
See More
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Study Overview: The study focuses on Phase 3 of the Eli Lilly trial, which aims to evaluate the effectiveness of a new treatment.
Primary Endpoint: The primary endpoint of the study is to demonstrate improved event-free survival rates among participants.
See More
LILLY'S RETEVMO (SELPERCATINIB) PROVIDES SIGNIFICANT EVENT-FREE SURVIVAL ADVANTAGE AS ADJUVANT TREATMENT FOR EARLY-STAGE RET FUSION-POSITIVE LUNG CANCER
Event-Free Survival Benefit: A recent study highlights the substantial event-free survival benefit of using LILLY's RETEVMO (selpercatinib) as an early-stage therapy for patients with positive lung cancer mutations.
Adjunct Therapy: RETEVMO is positioned as an adjunct therapy, enhancing treatment options for patients diagnosed with early-stage RET fusion-positive lung cancer.
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Eli Lilly's Late-Stage Trial Achieves Key Goals
- Trial Success: Eli Lilly announced that its TOGETHER-PsO open-label Phase 3b trial successfully met both primary and key secondary endpoints, demonstrating the efficacy of its weight loss therapy Zepbound combined with psoriasis therapy Taltz, marking a significant advancement for obese or overweight patients with plaque psoriasis.
- Significant Weight Loss: Over 36 weeks, 27% of patients receiving the combination therapy achieved at least a 10% weight loss and complete skin clearance, showcasing the potential of this combination therapy to improve patient quality of life, far exceeding the 5.8% achieved with Taltz alone.
- Efficacy Comparison: The key secondary endpoint revealed that patients on the combination regimen were 40% more likely to achieve PASI 100 compared to those receiving Taltz alone, further validating the advantages of using Zepbound with Taltz, which could enhance future market acceptance.
- Safety Profile: The trial reported mostly mild to moderate adverse events consistent with the known tolerability profiles of each drug, indicating the acceptability of this combination therapy in terms of safety, laying the groundwork for future regulatory discussions.
See More
Eli Lilly's Innovation and Growth Prospects
- Strong Clinical Execution: Eli Lilly achieved positive outcomes in nearly all R&D key events in 2025, showcasing exceptional performance in diabetes and weight loss medications, which is expected to further drive market share and revenue growth in the future.
- Cancer Drug Progress: The company's cancer medication, Jaypirca, excelled in a phase 3 trial and is on track for label expansions, which will provide new revenue streams and enhance its competitiveness in oncology treatment.
- AI Investment: Eli Lilly is investing in building the industry's largest AI supercomputer to accelerate drug development, which is expected to significantly improve clinical trial success rates and bolster the company's innovative standing and market leadership in the pharmaceutical sector.
- Robust Financial Performance: The company continues to report strong financial results, boasts a rich product pipeline, and rewards shareholders through increasing dividends and share buybacks, demonstrating its diversified growth potential beyond diabetes and weight loss markets.
See More
Eli Lilly Reports Positive Results for Retevmo in NSCLC Trial
- Trial Success: The LIBRETTO-432 trial demonstrated that Retevmo (selpercatinib) as adjuvant therapy significantly improved event-free survival (EFS) in early-stage RET fusion-positive non-small cell lung cancer (NSCLC) patients, indicating its potential value and likely enhancing market acceptance.
- Survival Trends Favorable: Although overall survival results were immature at the time of analysis, preliminary data showed a favorable trend for Retevmo, highlighting its importance in early treatment and potentially encouraging more patients to undergo genomic testing for optimized therapy.
- Patient Recruitment: The LIBRETTO-432 trial enrolled 151 patients randomized 1:1 to receive either Retevmo or placebo, ensuring the reliability and clinical applicability of the results, further validating the use of targeted therapies in lung cancer.
- Future Outlook: Eli Lilly plans to present detailed trial results at an upcoming medical congress and submit data to global health authorities, which is expected to accelerate the adoption of targeted therapies in early-stage NSCLC patients and promote the widespread use of genomic testing.
See More
ELI LILLY - SELPERCATINIB SHOWED PROMISING OVERALL SURVIVAL TRENDS, BUT RESULTS REMAINED IMMATURE DUE TO LIMITED EVENTS AT THE TIME OF ANALYSIS
Overall Survival Results: The analysis indicates a trend in favor of Selpercatinib, suggesting improved overall survival rates for patients.
Immaturity of Analysis: The findings are considered immature due to the limited number of events observed during the analysis period.
See More
ELI LILLY'S PHASE 3 LIBRETTO-432 TRIAL ACHIEVES PRIMARY GOAL WITH ENHANCED EVENT-FREE SURVIVAL
Study Overview: The study focuses on Phase 3 of the Eli Lilly trial, which aims to evaluate the effectiveness of a new treatment.
Primary Endpoint: The primary endpoint of the study is to demonstrate improved event-free survival rates among participants.
See More
LILLY'S RETEVMO (SELPERCATINIB) PROVIDES SIGNIFICANT EVENT-FREE SURVIVAL ADVANTAGE AS ADJUVANT TREATMENT FOR EARLY-STAGE RET FUSION-POSITIVE LUNG CANCER
Event-Free Survival Benefit: A recent study highlights the substantial event-free survival benefit of using LILLY's RETEVMO (selpercatinib) as an early-stage therapy for patients with positive lung cancer mutations.
Adjunct Therapy: RETEVMO is positioned as an adjunct therapy, enhancing treatment options for patients diagnosed with early-stage RET fusion-positive lung cancer.
See More
Eli Lilly's Late-Stage Trial Achieves Key Goals
- Trial Success: Eli Lilly announced that its TOGETHER-PsO open-label Phase 3b trial successfully met both primary and key secondary endpoints, demonstrating the efficacy of its weight loss therapy Zepbound combined with psoriasis therapy Taltz, marking a significant advancement for obese or overweight patients with plaque psoriasis.
- Significant Weight Loss: Over 36 weeks, 27% of patients receiving the combination therapy achieved at least a 10% weight loss and complete skin clearance, showcasing the potential of this combination therapy to improve patient quality of life, far exceeding the 5.8% achieved with Taltz alone.
- Efficacy Comparison: The key secondary endpoint revealed that patients on the combination regimen were 40% more likely to achieve PASI 100 compared to those receiving Taltz alone, further validating the advantages of using Zepbound with Taltz, which could enhance future market acceptance.
- Safety Profile: The trial reported mostly mild to moderate adverse events consistent with the known tolerability profiles of each drug, indicating the acceptability of this combination therapy in terms of safety, laying the groundwork for future regulatory discussions.
See More
