Spero Therapeutics Receives $25 Million Milestone Payment Triggered by GSK's NDA Submission
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 19 2025
0mins
Should l Buy GSK?
Spero Therapeutics (SPRO) announced that its development partner, GSK (GSK), filed a New Drug Application, NDA, resubmission to the U.S. Food and Drug Administration, FDA, for tebipenem HBr, an investigational oral carbapenem antibiotic being developed for the treatment of complicated urinary tract infections, cUTI, including pyelonephritis. The NDA submission triggers a $25 million milestone payment to Spero, expected to be received in Q1 2026.
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Analyst Views on GSK
Wall Street analysts forecast GSK stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for GSK is 38.72 USD with a low forecast of 20.15 USD and a high forecast of 55.60 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
1 Buy
2 Hold
3 Sell
Moderate Sell
Current: 59.170
Low
20.15
Averages
38.72
High
55.60
Current: 59.170
Low
20.15
Averages
38.72
High
55.60
About GSK
GSK plc is a biopharma company. The Company’s segments include Commercial Operations and Research and Development. Its portfolio and pipeline are focused on developing medicines and vaccines in four core therapeutic areas, which are the areas of human health it focuses on to prevent and treat disease: respiratory, immunology and inflammation; oncology; human immunodeficiency virus (HIV), and infectious diseases. Its specialty medicines prevent and treat diseases, from HIV to respiratory diseases, immune-mediated conditions like lupus, and cancer. Its vaccine portfolio includes over 20 vaccines to protect people from diseases and infections throughout their lives. General medicines include inhaled medicines for asthma and COPD to antibiotics. It develops and commercializes preclinical antibody-drug conjugate for Metastatic castration-resistant prostate cancer. Its portfolio also includes Efimosfermin, a fibroblast growth factor 21 (FGF21) analog therapeutic in clinical development.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Earnings Beat: GSK's fourth-quarter results exceeded expectations, and the company reaffirmed its profit growth projections for 2026, with analysts generally rating the stock as a Buy, indicating optimism about its future profitability.
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- Drug Approval: GSK announced that its biologic Nucala has been approved by the European Commission as an add-on maintenance treatment for adults with uncontrolled chronic obstructive pulmonary disease (COPD), marking a significant advancement in the company's respiratory disease portfolio.
- Clinical Trial Results: This approval is based on the Phase III MATINEE trial results, where Nucala demonstrated a clinically meaningful and statistically significant reduction in the annualized rate of moderate to severe COPD exacerbations compared to placebo.
- Market Potential: COPD affects over 390 million people globally, including around 40 million in Europe, and the approval of Nucala is expected to provide GSK with substantial revenue growth opportunities in this large market.
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See More
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- Clinical Trial Support: The approval is based on data from GSK's Phase 3 MATINEE trial, which demonstrated that Nucala, in combination with standard care, can effectively reduce the annualized rate of moderate/severe exacerbations in COPD patients, enhancing its clinical applicability.
- Market Potential: This approval allows Nucala to be marketed as an add-on maintenance treatment for adults with COPD characterized by high eosinophil counts, which is anticipated to drive revenue growth for GSK in the respiratory disease sector.
- Strategic Significance: Nucala was previously approved in the EU for four inflammatory diseases, and this expansion further solidifies GSK's position in the biopharmaceutical market, showcasing its ongoing commitment to innovative drug development.
See More
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- Investment Strategy Recommendations: Investors are advised to hold long-term quality assets while establishing protection bands to mitigate market volatility, especially given the current increase in market uncertainty, which helps balance risk and reward.
- Traditional Portfolio Adjustments: For those adhering to a traditional 60/40 stock-bond allocation, focusing on high-quality bonds and those with five-year durations or less is recommended to address inflation risks, ensuring stability and yield in their portfolios.
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See More
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- Sales Growth: The company achieved quarterly sales of $580.620 million, exceeding the analyst consensus estimate of $533.890 million, demonstrating strong market demand and driving sustained performance growth.
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- Sales Increase: Q4 sales hit $11.46 billion (£8.62 billion), an 8% year-over-year increase that exceeded analyst estimates of $11.19 billion, reflecting robust demand for vaccines and specialty medicines.
- Vaccine Sales Growth: Vaccine sales rose 4% to £2.29 billion, primarily driven by strong demand for Shingrix, Arexvy, and Meningitis vaccines outside the U.S., despite a decline in U.S. demand.
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