Pomerantz Investigates Zenas BioPharma After 51.86% Stock Drop
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 22 2026
0mins
Should l Buy ZBIO?
Source: PRnewswire
- Stock Price Plunge: Zenas BioPharma's stock dropped $17.89, or 51.86%, to close at $16.61 on January 5, 2026, following the announcement of its IgG4-RD trial results, indicating market concerns over the drug's commercial viability.
- Trial Results Disappointment: Although Zenas characterized the INDIGO trial results as 'positive,' analysts noted that the drug's efficacy fell short of the necessary threshold for commercial success, leading to diminished investor confidence.
- CEO Acknowledgment of Disappointment: During a conference call on January 6, 2026, Zenas's CEO admitted that the hazard ratio did not meet expectations, causing the stock to fall another $1.41, or 8.49%, further heightening concerns about the company's future.
- Legal Investigation Launched: Pomerantz LLP is investigating whether Zenas and its executives engaged in securities fraud or other unlawful business practices, which could significantly impact the company's future legal liabilities and financial health.
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Analyst Views on ZBIO
Wall Street analysts forecast ZBIO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZBIO is 41.20 USD with a low forecast of 19.00 USD and a high forecast of 55.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
4 Buy
1 Hold
0 Sell
Strong Buy
Current: 21.800
Low
19.00
Averages
41.20
High
55.00
Current: 21.800
Low
19.00
Averages
41.20
High
55.00
About ZBIO
Zenas BioPharma, Inc. is a clinical-stage global biopharmaceutical company focused on the development and commercialization of transformative therapies for patients with autoimmune diseases. The Company's lead product candidate, obexelimab, is a bifunctional monoclonal antibody designed to bind both CD19 and FcyRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. The Company is developing obexelimab as a potential immunology and inflammation (I&I) franchise for patients in several autoimmune diseases. The first three indications it is pursuing include immunoglobulin G4-related disease (IgG4-RD), relapsing multiple sclerosis (RMS) and systemic lupus erythematosus (SLE). Its other programs include ZB002 (an anti-TNFα monoclonal antibody), ZB004 (a CTLA-4-Ig fusion), and ZB001 and related programs. ZB002 is a recombinant human monoclonal antibody directed at human TNFα.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Obexelimab Achieves Significant Results in Multiple Sclerosis Trial
- Clinical Trial Success: Obexelimab achieved a 95% relative reduction in new Gd-enhancing T1 lesions in the MoonStone trial for Multiple Sclerosis, demonstrating its potential to transform treatment protocols for patients.
- Good Safety Profile: The trial indicated that Obexelimab was well tolerated with no new safety signals observed, which lays a solid foundation for future market introduction and boosts investor confidence.
- Long-term Efficacy Confirmation: Data from the 24-week follow-up showed sustained efficacy of Obexelimab, with Gd-enhancing T1 lesions decreasing from a baseline of 0.87 to 0.04, indicating its effectiveness and tolerability in long-term treatment.
- Broad Market Prospects: Zenas BioPharma plans to submit a Biologics License Application for Obexelimab to the FDA in 2026, which is expected to create significant market opportunities and further solidify its leadership position in the autoimmune disease sector.
See More
Zenas BioPharma CEO Buys $1M in Stock, Shares Rise 11%
- Executive Purchase: Zenas BioPharma CEO Lonnie Moulder bought over $1M worth of company stock at $17.96 per share, acquiring 57,000 shares, which reflects strong confidence in the company's future prospects.
- Increased Stake: Following this transaction, Moulder's total holdings in Zenas have risen to nearly 1.7 million shares, reinforcing his position as founder and chairman, which may enhance investor trust in the company.
- Upcoming Catalysts: Zenas is scheduled to present at the Guggenheim Emerging Outlook: Biotech Summit 2026 on February 11, 2026, which is expected to draw investor attention to the mid-stage trial results for its lead asset targeting systemic lupus erythematosus.
- Market Reaction: Despite earlier declines in Zenas's stock price due to disappointing late-stage trial results for its candidate against IgG4-related disease, the CEO's stock purchase may improve market sentiment and boost the share price.
See More
Pomerantz Investigates Zenas BioPharma After 51.86% Stock Drop
- Stock Price Plunge: Zenas BioPharma's stock dropped $17.89, or 51.86%, to close at $16.61 on January 5, 2026, following the announcement of its IgG4-RD trial results, indicating market concerns over the drug's commercial viability.
- Trial Results Disappointment: Although Zenas characterized the INDIGO trial results as 'positive,' analysts noted that the drug's efficacy fell short of the necessary threshold for commercial success, leading to diminished investor confidence.
- CEO Acknowledgment of Disappointment: During a conference call on January 6, 2026, Zenas's CEO admitted that the hazard ratio did not meet expectations, causing the stock to fall another $1.41, or 8.49%, further heightening concerns about the company's future.
- Legal Investigation Launched: Pomerantz LLP is investigating whether Zenas and its executives engaged in securities fraud or other unlawful business practices, which could significantly impact the company's future legal liabilities and financial health.
See More
Zenas BioPharma Under Investigation as Stock Plummets 51.86%
- Securities Fraud Investigation: Pomerantz LLP is investigating whether Zenas BioPharma has engaged in securities fraud or other unlawful business practices, which could undermine investor confidence and lead to further stock declines.
- Clinical Trial Setback: On January 5, 2026, Zenas announced results from the INDIGO trial, which were termed “positive,” yet analysts noted that the drug's efficacy fell short of the commercial viability threshold, potentially impacting future sales prospects.
- Stock Price Volatility: Following the trial results, Zenas's stock plummeted by 51.86% in one day, from $34.50 to $16.61, reflecting strong market concerns regarding the company's future outlook.
- CEO Acknowledges Disappointment: During a conference call on January 6, 2026, Zenas's CEO expressed disappointment that the hazard ratio did not meet expectations, leading to an additional 8.49% drop in stock price, closing at $15.20.
See More
Zenas BioPharma Grants 100,000 Stock Options to New Employee at $19.93 Exercise Price
- Stock Option Grant: On January 15, 2026, Zenas BioPharma granted 100,000 non-qualified stock options to a new employee at an exercise price of $19.93, aligning with Nasdaq listing rules to attract talent and enhance competitive positioning.
- Grant Terms: The options have a ten-year term and vest over four years, with 25% vesting after the first year and the remainder vesting in monthly installments, ensuring continued employee contribution during their tenure.
- Core Strategy: Zenas is focused on developing transformative therapies for autoimmune diseases, advancing two late-stage candidates, obexelimab and orelabrutinib, aimed at providing superior clinical benefits and enhancing market competitiveness.
- Product Advantages: Obexelimab, a bifunctional monoclonal antibody, effectively inhibits B cell activity, while orelabrutinib, a selective BTK inhibitor, targets pathogenic B cells in the central nervous system, showing potential in diseases like multiple sclerosis.
See More
Planet Labs PBC Secures Nine-Figure Deal with Swedish Armed Forces, Shares Surge 7%
- Stock Surge: Planet Labs PBC's announcement of a multi-year nine-figure agreement with the Swedish Armed Forces led to a 7% increase in share price to $24.29 on Monday, reflecting strong market confidence in the company's long-term contracts.
- Revenue Outlook Boost: Day One Biopharmaceuticals Inc reported preliminary 2025 OJEMDA net product revenue of $155.4 million, up 172% year-over-year, indicating robust growth potential in the biopharmaceutical sector that may attract more investor interest.
- Market Dynamics: Amid a broader decline in U.S. stocks, Wheels Up Experience Inc saw its shares jump 30.2% to $0.89, suggesting a market reassessment of its business model, potentially providing support for future financing and expansion.
- Increased Demand for Safe Assets: Growing concerns about Federal Reserve independence have led investors to shift towards safe-haven assets like gold, driving up precious metals stocks, which reflects market sensitivity to economic uncertainties and a preference for secure investments.
See More
Obexelimab Achieves Significant Results in Multiple Sclerosis Trial
- Clinical Trial Success: Obexelimab achieved a 95% relative reduction in new Gd-enhancing T1 lesions in the MoonStone trial for Multiple Sclerosis, demonstrating its potential to transform treatment protocols for patients.
- Good Safety Profile: The trial indicated that Obexelimab was well tolerated with no new safety signals observed, which lays a solid foundation for future market introduction and boosts investor confidence.
- Long-term Efficacy Confirmation: Data from the 24-week follow-up showed sustained efficacy of Obexelimab, with Gd-enhancing T1 lesions decreasing from a baseline of 0.87 to 0.04, indicating its effectiveness and tolerability in long-term treatment.
- Broad Market Prospects: Zenas BioPharma plans to submit a Biologics License Application for Obexelimab to the FDA in 2026, which is expected to create significant market opportunities and further solidify its leadership position in the autoimmune disease sector.
See More
Zenas BioPharma CEO Buys $1M in Stock, Shares Rise 11%
- Executive Purchase: Zenas BioPharma CEO Lonnie Moulder bought over $1M worth of company stock at $17.96 per share, acquiring 57,000 shares, which reflects strong confidence in the company's future prospects.
- Increased Stake: Following this transaction, Moulder's total holdings in Zenas have risen to nearly 1.7 million shares, reinforcing his position as founder and chairman, which may enhance investor trust in the company.
- Upcoming Catalysts: Zenas is scheduled to present at the Guggenheim Emerging Outlook: Biotech Summit 2026 on February 11, 2026, which is expected to draw investor attention to the mid-stage trial results for its lead asset targeting systemic lupus erythematosus.
- Market Reaction: Despite earlier declines in Zenas's stock price due to disappointing late-stage trial results for its candidate against IgG4-related disease, the CEO's stock purchase may improve market sentiment and boost the share price.
See More
Pomerantz Investigates Zenas BioPharma After 51.86% Stock Drop
- Stock Price Plunge: Zenas BioPharma's stock dropped $17.89, or 51.86%, to close at $16.61 on January 5, 2026, following the announcement of its IgG4-RD trial results, indicating market concerns over the drug's commercial viability.
- Trial Results Disappointment: Although Zenas characterized the INDIGO trial results as 'positive,' analysts noted that the drug's efficacy fell short of the necessary threshold for commercial success, leading to diminished investor confidence.
- CEO Acknowledgment of Disappointment: During a conference call on January 6, 2026, Zenas's CEO admitted that the hazard ratio did not meet expectations, causing the stock to fall another $1.41, or 8.49%, further heightening concerns about the company's future.
- Legal Investigation Launched: Pomerantz LLP is investigating whether Zenas and its executives engaged in securities fraud or other unlawful business practices, which could significantly impact the company's future legal liabilities and financial health.
See More
Zenas BioPharma Under Investigation as Stock Plummets 51.86%
- Securities Fraud Investigation: Pomerantz LLP is investigating whether Zenas BioPharma has engaged in securities fraud or other unlawful business practices, which could undermine investor confidence and lead to further stock declines.
- Clinical Trial Setback: On January 5, 2026, Zenas announced results from the INDIGO trial, which were termed “positive,” yet analysts noted that the drug's efficacy fell short of the commercial viability threshold, potentially impacting future sales prospects.
- Stock Price Volatility: Following the trial results, Zenas's stock plummeted by 51.86% in one day, from $34.50 to $16.61, reflecting strong market concerns regarding the company's future outlook.
- CEO Acknowledges Disappointment: During a conference call on January 6, 2026, Zenas's CEO expressed disappointment that the hazard ratio did not meet expectations, leading to an additional 8.49% drop in stock price, closing at $15.20.
See More
Zenas BioPharma Grants 100,000 Stock Options to New Employee at $19.93 Exercise Price
- Stock Option Grant: On January 15, 2026, Zenas BioPharma granted 100,000 non-qualified stock options to a new employee at an exercise price of $19.93, aligning with Nasdaq listing rules to attract talent and enhance competitive positioning.
- Grant Terms: The options have a ten-year term and vest over four years, with 25% vesting after the first year and the remainder vesting in monthly installments, ensuring continued employee contribution during their tenure.
- Core Strategy: Zenas is focused on developing transformative therapies for autoimmune diseases, advancing two late-stage candidates, obexelimab and orelabrutinib, aimed at providing superior clinical benefits and enhancing market competitiveness.
- Product Advantages: Obexelimab, a bifunctional monoclonal antibody, effectively inhibits B cell activity, while orelabrutinib, a selective BTK inhibitor, targets pathogenic B cells in the central nervous system, showing potential in diseases like multiple sclerosis.
See More
Planet Labs PBC Secures Nine-Figure Deal with Swedish Armed Forces, Shares Surge 7%
- Stock Surge: Planet Labs PBC's announcement of a multi-year nine-figure agreement with the Swedish Armed Forces led to a 7% increase in share price to $24.29 on Monday, reflecting strong market confidence in the company's long-term contracts.
- Revenue Outlook Boost: Day One Biopharmaceuticals Inc reported preliminary 2025 OJEMDA net product revenue of $155.4 million, up 172% year-over-year, indicating robust growth potential in the biopharmaceutical sector that may attract more investor interest.
- Market Dynamics: Amid a broader decline in U.S. stocks, Wheels Up Experience Inc saw its shares jump 30.2% to $0.89, suggesting a market reassessment of its business model, potentially providing support for future financing and expansion.
- Increased Demand for Safe Assets: Growing concerns about Federal Reserve independence have led investors to shift towards safe-haven assets like gold, driving up precious metals stocks, which reflects market sensitivity to economic uncertainties and a preference for secure investments.
See More
