Novartis Unveils New Data at ASN Kidney Week and AHA Scientific Sessions Highlighting Progress in CRM Portfolio and Pipeline
Novartis Data Presentation: Novartis will showcase new findings from 33 abstracts related to its Cardiovascular, Renal, and Metabolic (CRM) disease portfolio at the ASN Kidney Week 2025 and AHA Scientific Sessions 2025, emphasizing their commitment to innovative therapies for heart and kidney conditions.
Key Research Highlights: The presentations will include interim results from trials on Fabhalta (iptacopan) for IgA nephropathy and C3 glomerulopathy, as well as data on Leqvio (inclisiran) for post-acute coronary syndrome patients, highlighting the importance of early detection and treatment strategies.
Focus on Patient Outcomes: The studies aim to improve patient outcomes by addressing root causes of diseases, with a particular emphasis on the long-term safety and efficacy of treatments in various patient populations.
Novartis' Vision: Novartis is dedicated to redefining approaches to CRM diseases, leveraging a robust portfolio and pipeline to transform outcomes and enhance the quality of life for patients globally.
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- New Research Center: Novartis has broken ground on a 466,000-square-foot biomedical research center in San Diego, expected to begin operations in 2029 and employ 1,000 workers, significantly enhancing its R&D capabilities in the biomedical field.
- AI Utilization: The center will leverage artificial intelligence, data, and computational capabilities to drive innovation in biomedical research, thereby boosting Novartis's competitiveness in the global pharmaceutical industry.
- Massive Investment Plan: Novartis announced a $23 billion investment in the U.S., which includes a new manufacturing facility in North Carolina and a radioligand therapy manufacturing facility in Carlsbad, California, demonstrating its commitment to the U.S. market.
- Manufacturing Expansion: The company is also planning new radioligand therapy manufacturing locations in Florida and Texas to meet the growing market demand, further solidifying its leadership position in the biopharmaceutical sector.

- Stock Performance: Biogen's stock experienced an increase on Friday despite facing declining sales.
- Drug Portfolio Issues: The company's drug portfolio showed poor performance in the fourth quarter, contributing to investor concerns.
- Amazon Earnings Preview: Amazon is set to release its earnings report on Thursday, with its stock dropping 2.4% ahead of the announcement, indicating cautious investor sentiment that may impact short-term market confidence.
- Alphabet's Strong Performance: Alphabet exceeded Wall Street expectations in its fourth-quarter earnings report released on Wednesday, although its stock fell about 1% in after-hours trading; the projected capital expenditures for 2026 are expected to reach between $175 billion and $185 billion, nearly double that of 2025, reflecting a strong commitment to future growth.
- Qualcomm's Disappointing Guidance: Qualcomm reported quarterly earnings that surpassed expectations, yet its stock fell 9% in after-hours trading due to disappointing forward guidance, highlighting investor concerns about future performance, with shares down nearly 13% year-to-date in 2026.
- Strong Consumer Staples Sector: The Consumer Staples Select Sector SPDR ETF (XLP) has risen for four consecutive days, gaining over 1% each day and hitting new highs in the past three sessions, indicating strong performance in 2026 with over 12% growth year-to-date, making it the third-best performing sector in the market.
- Sales Growth Challenges: Novartis reported a 1% year-over-year increase in net sales to $13.34 billion for Q4 2025, falling short of Wall Street's $13.78 billion estimate, indicating challenges in achieving sales growth amid fierce competition.
- Core Operating Income Slightly Up: Core operating income rose 1% to $4.93 billion, benefiting from increased government grant income and reduced SG&A expenses, although higher R&D costs partially offset these gains, resulting in a core operating income margin of 37.0%.
- Strong Performance from Blockbusters: Demand for blockbuster therapies like Kisqali and Kesimpta surged by 44% and 27% respectively, driving overall performance and demonstrating Novartis's competitive strength in oncology and multiple sclerosis markets.
- Cautiously Optimistic Outlook: Novartis expects low single-digit growth in net sales for 2026, while core operating income may decline slightly; however, the incoming CFO indicated that operating income is set to grow significantly in the second half of the year, suggesting strong potential for future growth.
- Earnings Highlights: Novartis reported a Q4 non-GAAP EPS of $2.03, beating expectations by $0.03, indicating stable profitability; however, total revenue of $13.34 billion grew only 1.4% year-over-year, missing market expectations, reflecting the impact of generic erosion in the U.S. market.
- Sales and Revenue: Net sales decreased by 1% year-over-year, with a 1% increase in USD terms when excluding currency effects, suggesting that while the company maintains some revenue levels amid market challenges, core operating income growth of only 1% indicates pressure on profitability.
- Cash Flow Situation: Free cash flow amounted to $1.7 billion, down 54% year-over-year, primarily driven by lower cash flows from operating activities, which may impact the company's reinvestment capabilities and shareholder return strategies.
- Future Outlook: Novartis expects low single-digit growth in net sales and a slight decline in core operating income for 2026; despite facing the largest patent expiry in its history, the company remains optimistic about its mid-term guidance, emphasizing the resilience and ongoing growth potential of its business.
- Dividend Increase: Novartis' board proposes a dividend of CHF 3.70 per share for 2025, representing a 5.7% increase from CHF 3.50 in the previous year, indicating the company's ongoing commitment to stable cash flow and shareholder returns.
- Shareholder Voting: The dividend proposal will be voted on at the Annual General Meeting scheduled for March 6, 2026, reflecting the importance of corporate governance transparency and shareholder engagement in decision-making processes.
- Market Reaction: Despite the dividend increase, Novartis faces a rating downgrade, leading to cautious market expectations regarding future growth, which may impact investor confidence and stock performance.
- Outlook Challenges: Novartis anticipates a transition year in 2026, with a soft outlook for FY26, highlighting the challenges the company faces in strategic adjustments and market adaptation.









