NeOnc Secures $16 Million PIPE Investment for CNS Cancer Therapies
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 30 2026
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Should l Buy NTHI?
Source: Newsfilter
- Financing Agreement: NeOnc Technologies Holdings, Inc. announced a securities purchase agreement with Cinctive Capital Management to sell up to 2,222,222 shares through a PIPE, expected to generate approximately $16 million in gross proceeds, which will be used for debt repayment and working capital.
- Investor Confidence Boosted: The $10 million investment from Cinctive Capital reflects strong confidence in NeOnc's technology and clinical assets, particularly underscored by the leadership of Co-Founder Rich Schimel, enhancing the strategic significance of this investment and market recognition of the company.
- Clinical Trials Acceleration: NeOnc stated that this funding will provide essential capital to accelerate its clinical trials, especially for its NEO100 and NEO212 therapies in Phase II, which aim to bypass the blood-brain barrier and address significant challenges in CNS cancer treatment.
- Patent Protection Advantage: NeOnc's NEO™ drug development platform, with patent protections extending to 2038, demonstrates the company's long-term potential in innovative drug development, which is expected to provide strong support for future market competition.
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About NTHI
NeOnc Technologies Holdings, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on establishing treatments for intracranial malignancies, such as aggressive cancers located in the brain. It is the developer of a novel molecular technology that provides enhanced targeted delivery of technologies for treating central nervous system diseases. It is developing novel drug delivery methods to be used in combination with novel drug candidates. The Company has two lead products in development: NEO100 and NEO212. NEO100 is a purified form of perillyl acid (POH) which is administered to brain cancer patients via intranasal delivery. NEO212 is a covalently conjugated molecule combining the chemotherapeutic drug temozolomide with perillyl alcohol. NEO212 is undergoing development towards intranasal application specifically for patients with uncontrolled brain metastases derived from peripheral tumors (lung, breast, skin, and others).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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NeOnc Secures $16 Million PIPE Investment for CNS Cancer Therapies
- Financing Agreement: NeOnc Technologies Holdings, Inc. announced a securities purchase agreement with Cinctive Capital Management to sell up to 2,222,222 shares through a PIPE, expected to generate approximately $16 million in gross proceeds, which will be used for debt repayment and working capital.
- Investor Confidence Boosted: The $10 million investment from Cinctive Capital reflects strong confidence in NeOnc's technology and clinical assets, particularly underscored by the leadership of Co-Founder Rich Schimel, enhancing the strategic significance of this investment and market recognition of the company.
- Clinical Trials Acceleration: NeOnc stated that this funding will provide essential capital to accelerate its clinical trials, especially for its NEO100 and NEO212 therapies in Phase II, which aim to bypass the blood-brain barrier and address significant challenges in CNS cancer treatment.
- Patent Protection Advantage: NeOnc's NEO™ drug development platform, with patent protections extending to 2038, demonstrates the company's long-term potential in innovative drug development, which is expected to provide strong support for future market competition.
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- Survival Rate Improvement: 36% of patients demonstrated survival of 18 months or longer post-NEO100 treatment, showcasing the therapy's potential for long-term survival in heavily pretreated populations, which may shift treatment paradigms in this field.
- No Significant Toxicity: The intranasal administration of NEO100 has shown no significant toxicity even with prolonged and chronic dosing, indicating a high safety profile that could enhance patient treatment experiences.
- Expanded Clinical Data: The growing clinical cohort reinforces the treatment's effectiveness, bolstering confidence in NEO100 as a first-in-class CNS-penetrant metabolic therapy, potentially driving significant advancements in neuro-oncology.
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- International Expansion Update: YY Group will provide updates on its international expansion in Hong Kong, UAE, and Southeast Asia, showcasing AI-enabled workforce automation and strong revenue momentum, indicating its competitiveness in the premium client market.
- Strategic Acquisition Discussion: Roadzen's leadership will discuss its strategic acquisition plans and the scaling of its AI-driven auto insurance and claims ecosystem, demonstrating its innovative capabilities and market potential in the insurance industry.
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- Financing Agreement: NeOnc Technologies Holdings, Inc. announced a securities purchase agreement with Cinctive Capital Management to sell up to 2,222,222 shares through a PIPE, expected to generate approximately $16 million in gross proceeds, which will be used for debt repayment and working capital.
- Investor Confidence Boosted: The $10 million investment from Cinctive Capital reflects strong confidence in NeOnc's technology and clinical assets, particularly underscored by the leadership of Co-Founder Rich Schimel, enhancing the strategic significance of this investment and market recognition of the company.
- Clinical Trials Acceleration: NeOnc stated that this funding will provide essential capital to accelerate its clinical trials, especially for its NEO100 and NEO212 therapies in Phase II, which aim to bypass the blood-brain barrier and address significant challenges in CNS cancer treatment.
- Patent Protection Advantage: NeOnc's NEO™ drug development platform, with patent protections extending to 2038, demonstrates the company's long-term potential in innovative drug development, which is expected to provide strong support for future market competition.
See More
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- Blockchain Infrastructure Acceleration: TokenFI's Chief Revenue Officer Pedro Vidal discussed strategies for accelerating institutional adoption of blockchain tokenization, aiming to build scalable, compliance-ready infrastructure for real asset issuance, which is expected to drive transformation in financial markets.
- New Oncology Treatment Platform: NeOnc Technologies' CEO Amir Heshmatpour introduced an intranasal drug delivery platform targeting aggressive brain cancers along with its clinical and regulatory roadmap, potentially providing new treatment options and improving survival rates for patients.
- AI-Driven Drug Discovery: Lantern Pharma's CEO Panna Sharma outlined their AI-driven approach to oncology drug discovery, enhancing research speed and capital efficiency, which is anticipated to increase clinical success rates and expedite new drug market entry.
- Infrastructure Investment Strategy: Mataterra Holdings' co-chairmen Monika Proffitt and Douglas Anderson provided strategic insights on global infrastructure development and real asset tokenization, emphasizing the importance of capital formation to meet future market demands.
See More
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- Clinical Results Update: NeOnc Technologies reports that its NEO100 therapy achieved a significant radiographic remission rate of 24% in 25 patients, which is a 300% increase over the typical 8% seen with salvage therapies, indicating strong efficacy and competitive potential in the market.
- Survival Rate Improvement: Among patients treated with NEO100, 36% remained alive 18 months post-treatment, suggesting that this therapy may provide durable survival benefits in heavily pretreated populations, thereby altering treatment strategies.
- No Significant Toxicity: The intranasal administration of NEO100 has shown no significant toxicity even with prolonged use, ensuring patient safety and providing strong support for its clinical application.
- Broad Treatment Prospects: As the dataset expands, NEO100 is emerging as a potential first-in-class CNS-penetrant metabolic therapy, marking a possible paradigm shift in the treatment of IDH1-mutant high-grade gliomas and pushing the industry towards more effective treatment options.
See More
NeOnc Technologies Reports 24% Radiographic Response with NEO100 in CNS Cancer Trials
- Significant Efficacy: Among 25 patients treated with NEO100, 6 (24%) achieved significant radiographic remission, representing a 300% increase over the typical 8% response rate seen with salvage therapies, indicating NEO100's potential as an effective option for recurrent IDH1-mutant high-grade gliomas.
- Survival Rate Improvement: 36% of patients demonstrated survival of 18 months or longer post-NEO100 treatment, showcasing the therapy's potential for long-term survival in heavily pretreated populations, which may shift treatment paradigms in this field.
- No Significant Toxicity: The intranasal administration of NEO100 has shown no significant toxicity even with prolonged and chronic dosing, indicating a high safety profile that could enhance patient treatment experiences.
- Expanded Clinical Data: The growing clinical cohort reinforces the treatment's effectiveness, bolstering confidence in NEO100 as a first-in-class CNS-penetrant metabolic therapy, potentially driving significant advancements in neuro-oncology.
See More
NeOnc Technologies' NEO100 Therapy Shows Significant Antitumor Enhancement with Ultrasound
- Research Collaboration Findings: A study from the University of Southern California demonstrates that ultrasound significantly enhances NEO100's therapeutic potency, driving strong antitumor effects across various brain tumor types, indicating its potential for clinical application.
- Technological Innovation: Utilizing an AI-driven, 3D bioprinting New Approach Methodology, researchers rapidly generate physiologically relevant patient-derived tumor organoids within hours, significantly accelerating biomedical research and aligning with NIH objectives to reduce animal testing.
- Clinical Trial Prospects: Validation studies reveal that NEO100 exhibits markedly enhanced tumor-killing activity when combined with focused ultrasound, supporting its advancement into future clinical trials for a wide range of brain tumors, thereby broadening its commercial and clinical opportunities.
- Market Potential: The breakthrough provides strong external validation for NEO100's potential as a first-in-class, noninvasive sonodynamic therapy, significantly expanding its market opportunities beyond current indications through the integration of AI, 3D bioprinting, and ultrasound technology.
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