IDEAYA Biosciences Updates 2026 Corporate Objectives
IDEAYA Biosciences provided a business update including an overview of key corporate objectives for 2026. 2026 Corporate Objectives: Darovasertib in uveal melanoma - Topline results, including progression free survival data, from ongoing registrational Phase 2/3 OptimUM-02 trial of the darovasertib and crizotinib combination in first line patients with HLAA2-negative metastatic UM are expected in Q1 '26; Darovasertib is anticipated to be in three randomized, Phase 3 registrational trials across all stages of uveal melanoma by H1 '26; Complete enrollment of approximately 80 HLAA2-positive mUM patients in ongoing single-arm, Phase 2 OptimUM-01 trial of darovasertib in combination with crizotinib by Q2 '26. Antibody-drug Conjugate + DNA damage response combinations - IDE849: target to initiate a monotherapy registrational study in the second line/refractory setting of small cell lung cancer and/or neuroendocrine carcinomas by the end of 2026; IDE034: initiate Phase 1 dose escalation trial in Q1 '26; IDE161: initiate clinical combination studies with IDE849 in SCLC, NEC and other DLL3-overexpressing solid tumors in Q2 '26. MTAP Pathway - IDE397: provide updated data from Phase 1/2 combination trial with Trodelvy in MTAP-deleted urothelial cancer at a medical conference in 2026
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- Investor Event Schedule: IDEAYA Biosciences will participate in Citi's 2026 Virtual Oncology Leadership Summit on February 18, 2026, showcasing its latest advancements in precision medicine oncology, which is expected to attract investor interest and enhance the company's visibility.
- Virtual Fireside Chat: The company will also host a virtual fireside chat on February 23, 2026, led by Umer Raffat of Evercore ISI, aimed at discussing its product candidates and R&D strategies in depth, further enhancing investor engagement.
- Webcast Availability: Live audio of the events will be available on IDEAYA's website under the
- Investor Event Schedule: IDEAYA Biosciences will participate in Citi's 2026 Virtual Oncology Leadership Summit on February 18, 2026, featuring a fireside chat with executives including Chief Medical Officer Darrin Beaupre, which is expected to enhance the company's visibility among investors.
- Interactive Online Opportunities: The company will also host a virtual fireside chat on February 23, 2026, with CEO Yujiro S. Hata and other executives discussing their leadership in precision medicine, further solidifying their market position.
- Live Webcast and Replay: All events will be available via live audio webcast on IDEAYA's website under the
- Options Grant Overview: On January 29, 2026, IDEAYA Biosciences granted 44,200 non-qualified stock options to a new employee, aimed at attracting top talent in accordance with Nasdaq Listing Rule 5635(c)(4).
- Exercise Price Details: The stock options have an exercise price of $32.99 per share, matching the closing price of IDEAYA's common stock on the grant date, thereby aligning employee interests with company performance.
- Vesting Schedule: The options have a 10-year term with a four-year vesting period, where 25% vests on the first anniversary and the remaining 75% vests in equal monthly installments over the next three years, incentivizing long-term employee retention and contribution.
- Strategic Focus: IDEAYA is committed to precision medicine and oncology, focusing on developing transformative therapies for cancer by integrating expertise in small-molecule drug discovery, structural biology, and bioinformatics to advance personalized treatment options.
- Options Grant: On January 29, 2026, IDEAYA granted 44,200 non-qualified stock options to a new employee, aimed at attracting top talent to the company in accordance with Nasdaq Listing Rule 5635(c)(4).
- Incentive Plan Context: The stock options were granted under the 2023 Employment Inducement Incentive Award Plan, specifically designed for individuals who were not previously employed by IDEAYA, reflecting the company's commitment to new hires.
- Exercise Price: The stock options have an exercise price of $32.99 per share, equal to the closing price of IDEAYA's common stock on the grant date on the Nasdaq Global Select Market, ensuring employees receive fair market value.
- Vesting Schedule: The options will vest over four years, with 25% vesting on the first anniversary and the remaining 75% vesting in equal monthly installments over the next three years, ensuring continued employee service to IDEAYA for incentive eligibility.
- Pipeline Advancement: In 2025, IDEAYA successfully advanced multiple clinical projects, filing four INDs resulting in nine clinical programs, demonstrating the company's strong execution and readiness in the precision medicine oncology sector.
- Key Trial Plans: In 2026, IDEAYA plans to advance four registrational trials, including IDE849 as a monotherapy for neuroendocrine cancer and darovasertib for both pre-metastatic and metastatic uveal melanoma, aiming to improve patient prognosis and quality of life.
- Funding Assurance: The company expects its cash runway to support operations into 2030, ensuring the continued advancement of key combination therapies in high unmet need cancer areas, thereby enhancing its market competitiveness.
- Strategic Vision: IDEAYA is committed to developing targeted cancer therapies, particularly in the uveal melanoma space where FDA-approved treatments are lacking, showcasing its leadership and innovative potential in precision oncology.

- Advancement of Registrational Trials: IDEAYA plans to advance four registrational trials in 2026, including darovasertib for uveal melanoma, aimed at improving patient prognosis and addressing the lack of FDA-approved therapies.
- Clinical Data Release: Topline PFS data from the darovasertib and crizotinib combination is expected in Q1 2026, and if positive, will support a potential accelerated approval filing in the U.S., enhancing market competitiveness.
- Financial Assurance: As of September 30, 2025, IDEAYA has approximately $1.1 billion in cash and cash equivalents, expected to fund its operating plan into 2030, ensuring ongoing investment in R&D.
- New Drug Development: The company plans to initiate a registrational study for IDE849 targeting small cell lung cancer and neuroendocrine carcinomas by the end of 2026, showcasing its ongoing innovation in precision medicine.








