Galecto Expects to Initiate Anti-MutCALR Clinical Development in 2026
The company states: "2026 is expected to be a foundational year for Galecto as the company initiates the clinical development of its anti-mutCALR pipeline candidates. DMR-001 is a potentially best-in-class anti-mutCALR monoclonal antibody demonstrated to have highly potent activity in both Type 1 and Type 2 mutCALR-driven preclinical models, supporting its potential to address the full spectrum of CALR mutations in both essential thrombocythemia and myelofibrosis. DMR-001 is engineered with validated half-life extension technology to enable infrequent low-volume, subcutaneous dosing to maximize target coverage and patient convenience. An Investigational New Drug application ("IND"), or equivalent, submission for DMR-001, with anticipated first-in-human dosing via subcutaneous administration, is expected to occur in mid-2026, with Phase 1 proof-of-concept data anticipated in 2027. DMR-002 is an additional anti-mutCALR antibody. An IND, or equivalent, submission for DMR-002 is planned for the second half of 2026. GB3226 is a dual ENL-YEATS and FLT3 inhibitor for multiple genetic subsets of acute myeloid leukemia. An IND submission is planned for the first quarter of 2026. The Company anticipates that its cash balance, following $285 million raised in the November PIPE, provides operational runway into 2029."
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Galecto Appoints New Executives to Advance DMR-001 Clinical Trials
- Executive Appointments: Galecto has appointed Sherwin Sattarzadeh as COO and Becker Hewes as CMO, both from Blueprint Medicines, leveraging their 20+ years of drug development experience to drive DMR-001 into clinical trials.
- Clinical Advancement: DMR-001, a monoclonal antibody targeting mutant calreticulin, is on track for IND submission in mid-2026, with plans for first-in-human dosing via subcutaneous administration, marking a significant step in blood cancer treatment.
- Financial Position: The company's cash balance, including $285 million raised in a PIPE in November 2025, provides a financial runway into 2029 to support multiple data milestones, including Phase 1 clinical proof-of-concept data for DMR-001 expected in 2027.
- Incentive Plan: The appointments of Sattarzadeh and Hewes come with stock incentive grants of 190,376 and 264,629 restricted stock units respectively, reflecting the company's commitment to its executive team and confidence in future growth.
Aptevo Therapeutics Announces 1-for-18 Reverse Stock Split, Shares Plunge 38.4%
- Reverse Stock Split Announcement: Aptevo Therapeutics has announced a 1-for-18 reverse stock split effective December 29, converting every 18 shares into one, which has led to a significant 38.4% drop in share price to $0.57, indicating a negative market reaction despite prior shareholder approval in July.
- Severe Market Reaction: Following the reverse stock split announcement, Aptevo's shares plummeted sharply during Friday's session, reflecting investor concerns about the company's future prospects, which could adversely affect its financing capabilities and market confidence.
- Shareholder Approval Context: The final ratio for the reverse split was approved by the board in mid-December, despite having received shareholder support at the July annual meeting, yet the market's response raises questions about the company's governance and strategic direction.
- Industry Impact: The sharp decline in Aptevo's stock price may affect its competitive position in the biopharmaceutical sector, particularly regarding financing and partnership opportunities, as investors may reassess its investment value.
Galecto Grants 312,535 Stock Options to New Employee
- Stock Option Grant: On December 15, 2025, Galecto's Board approved the grant of 312,535 non-qualified stock options to a new employee at an exercise price of $32.00 per share, aimed at attracting talent and enhancing the company's competitive edge.
- Incentive Plan: The grant follows the company's 2022 Inducement Plan, with options vesting 25% on the first anniversary and subsequently 1/48th monthly, ensuring employee retention to achieve long-term objectives.
- Talent Attraction: By offering attractive stock options, Galecto aims to attract and retain key talent to support its innovative R&D in hematological cancer treatments, thereby strengthening its market position in the biotechnology sector.
- Future Outlook: Galecto plans to submit an IND application for its lead asset DMR-001 in mid-2026, with the new employee's addition expected to accelerate the R&D process and drive breakthroughs in antibody therapies.
Galecto Grants 312,535 Stock Options to New Employee
- Stock Option Grant: On December 15, 2025, Galecto's Board approved the grant of 312,535 non-qualified stock options to a new employee at an exercise price of $32.00 per share, aimed at attracting talent and enhancing the company's competitive edge.
- Incentive Plan: The grant is made under the Company's 2022 Inducement Plan, with options vesting 25% on the first anniversary and 1/48th monthly thereafter, ensuring the employee's continued employment to earn the options.
- Talent Attraction: By offering attractive stock options, Galecto aims to draw key talent to support its clinical development in hematological cancer treatments, thereby strengthening its market position in the biotechnology sector.
- Future Outlook: Galecto expects to submit an IND application for its lead asset DMR-001 in mid-2026, further advancing its antibody therapeutic pipeline and enhancing the company's innovative capabilities in treating blood cancers.
Guggenheim Begins Coverage of Galecto with a Buy Rating and Sets Price Target at $32
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Rocket Lab Shares Surge Over 9%; Check Out 20 Stocks Making Moves in Premarket Trading
Rocket Lab Financial Results: Rocket Lab Corp reported third-quarter revenue of $155.05 million, surpassing estimates, and a loss of three cents per share, which was better than the expected loss of 11 cents. The company's shares rose 9.3% in pre-market trading.
Fourth-Quarter Expectations: The company anticipates fourth-quarter revenue between $170 million and $180 million, slightly below estimates, and expects an adjusted EBITDA loss of $23 million to $29 million.
Pre-Market Stock Movements: Several stocks saw significant pre-market trading movements, with MSP Recovery Inc gaining 81% and Hitek Global Inc dropping 34.9% after previous fluctuations.
Other Notable Stocks: Companies like Kaltura Inc and RealReal Inc reported better-than-expected financial results, leading to notable gains in their stock prices, while others like Outset Medical Inc and Vor Biopharma Inc faced declines due to disappointing earnings or stock offerings.
Galecto Appoints New Executives to Advance DMR-001 Clinical Trials
- Executive Appointments: Galecto has appointed Sherwin Sattarzadeh as COO and Becker Hewes as CMO, both from Blueprint Medicines, leveraging their 20+ years of drug development experience to drive DMR-001 into clinical trials.
- Clinical Advancement: DMR-001, a monoclonal antibody targeting mutant calreticulin, is on track for IND submission in mid-2026, with plans for first-in-human dosing via subcutaneous administration, marking a significant step in blood cancer treatment.
- Financial Position: The company's cash balance, including $285 million raised in a PIPE in November 2025, provides a financial runway into 2029 to support multiple data milestones, including Phase 1 clinical proof-of-concept data for DMR-001 expected in 2027.
- Incentive Plan: The appointments of Sattarzadeh and Hewes come with stock incentive grants of 190,376 and 264,629 restricted stock units respectively, reflecting the company's commitment to its executive team and confidence in future growth.
Aptevo Therapeutics Announces 1-for-18 Reverse Stock Split, Shares Plunge 38.4%
- Reverse Stock Split Announcement: Aptevo Therapeutics has announced a 1-for-18 reverse stock split effective December 29, converting every 18 shares into one, which has led to a significant 38.4% drop in share price to $0.57, indicating a negative market reaction despite prior shareholder approval in July.
- Severe Market Reaction: Following the reverse stock split announcement, Aptevo's shares plummeted sharply during Friday's session, reflecting investor concerns about the company's future prospects, which could adversely affect its financing capabilities and market confidence.
- Shareholder Approval Context: The final ratio for the reverse split was approved by the board in mid-December, despite having received shareholder support at the July annual meeting, yet the market's response raises questions about the company's governance and strategic direction.
- Industry Impact: The sharp decline in Aptevo's stock price may affect its competitive position in the biopharmaceutical sector, particularly regarding financing and partnership opportunities, as investors may reassess its investment value.
Galecto Grants 312,535 Stock Options to New Employee
- Stock Option Grant: On December 15, 2025, Galecto's Board approved the grant of 312,535 non-qualified stock options to a new employee at an exercise price of $32.00 per share, aimed at attracting talent and enhancing the company's competitive edge.
- Incentive Plan: The grant follows the company's 2022 Inducement Plan, with options vesting 25% on the first anniversary and subsequently 1/48th monthly, ensuring employee retention to achieve long-term objectives.
- Talent Attraction: By offering attractive stock options, Galecto aims to attract and retain key talent to support its innovative R&D in hematological cancer treatments, thereby strengthening its market position in the biotechnology sector.
- Future Outlook: Galecto plans to submit an IND application for its lead asset DMR-001 in mid-2026, with the new employee's addition expected to accelerate the R&D process and drive breakthroughs in antibody therapies.
Galecto Grants 312,535 Stock Options to New Employee
- Stock Option Grant: On December 15, 2025, Galecto's Board approved the grant of 312,535 non-qualified stock options to a new employee at an exercise price of $32.00 per share, aimed at attracting talent and enhancing the company's competitive edge.
- Incentive Plan: The grant is made under the Company's 2022 Inducement Plan, with options vesting 25% on the first anniversary and 1/48th monthly thereafter, ensuring the employee's continued employment to earn the options.
- Talent Attraction: By offering attractive stock options, Galecto aims to draw key talent to support its clinical development in hematological cancer treatments, thereby strengthening its market position in the biotechnology sector.
- Future Outlook: Galecto expects to submit an IND application for its lead asset DMR-001 in mid-2026, further advancing its antibody therapeutic pipeline and enhancing the company's innovative capabilities in treating blood cancers.
Guggenheim Begins Coverage of Galecto with a Buy Rating and Sets Price Target at $32
Real-time Intelligence: Benzinga Pro offers the fastest news alerts for traders to stay updated on market movements.
Exclusive Stories: The platform provides unique stories generated by Benzinga reporters, enhancing the trading experience for its users.
Community of Traders: Over 10,000 serious traders are part of the Benzinga Pro community, sharing insights and strategies.
Market Winning Tools: Benzinga Pro equips traders with tools and information to improve their chances of success in the stock market.
Rocket Lab Shares Surge Over 9%; Check Out 20 Stocks Making Moves in Premarket Trading
Rocket Lab Financial Results: Rocket Lab Corp reported third-quarter revenue of $155.05 million, surpassing estimates, and a loss of three cents per share, which was better than the expected loss of 11 cents. The company's shares rose 9.3% in pre-market trading.
Fourth-Quarter Expectations: The company anticipates fourth-quarter revenue between $170 million and $180 million, slightly below estimates, and expects an adjusted EBITDA loss of $23 million to $29 million.
Pre-Market Stock Movements: Several stocks saw significant pre-market trading movements, with MSP Recovery Inc gaining 81% and Hitek Global Inc dropping 34.9% after previous fluctuations.
Other Notable Stocks: Companies like Kaltura Inc and RealReal Inc reported better-than-expected financial results, leading to notable gains in their stock prices, while others like Outset Medical Inc and Vor Biopharma Inc faced declines due to disappointing earnings or stock offerings.
