Galapagos Presents New GLPG5101 Data with 100% Response Rate in MCL Patients
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 08 2025
0mins
Should l Buy GLPG?
Source: Globenewswire
- Significant Response Rate: In the ATALANTA-1 study, 25 MCL patients treated with GLPG5101 achieved a 100% objective response rate, with 96% attaining complete responses, highlighting the therapy's efficacy and potential market appeal in high-risk populations.
- Rapid Treatment Cycle: The vein-to-vein time for GLPG5101 is only seven days, resulting in a low dropout rate of 4% and eliminating the need for bridging therapy, thereby increasing access to CAR T-cell therapy for more patients and enhancing treatment accessibility.
- Good Safety Profile: Among the 24 treated patients, no Grade ≥ 3 cytokine release syndrome (CRS) was observed, and only one case of Grade ≥ 3 neurological adverse event occurred, indicating that GLPG5101 has a favorable safety profile, which may boost patient confidence in treatment.
- Strategic Transformation: Galapagos intends to wind down its cell therapy activities while continuing clinical studies and considering acquisition proposals, demonstrating the company's ongoing focus on its core business during this transformation phase.
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Analyst Views on GLPG
Wall Street analysts forecast GLPG stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for GLPG is 30.50 USD with a low forecast of 22.00 USD and a high forecast of 40.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
4 Analyst Rating
1 Buy
1 Hold
2 Sell
Hold
Current: 33.380
Low
22.00
Averages
30.50
High
40.00
Current: 33.380
Low
22.00
Averages
30.50
High
40.00
About GLPG
Galapagos NV is a Belgium-based clinical-stage biotechnology company. The Company is engaged in the discovery and development of small molecule medicines with modes of action. Its pipeline comprises Phase 3, 2, 1, pre-clinical studies and discovery small-molecule and antibody programs in cystic fibrosis, inflammation, and other indications. The Company focuses on developing a portfolio of clinical-stage therapies for the enhancement of existing treatment paradigms. It develops transformational medicines in areas of high unmet need by combining internal with external science with the goal to add years of life and improve of life of patients across the globe. It discovers which proteins that are involved in causing diseases such as, rheumatoid, arthritis, inflammatory bowel disease and fibrosis. The Company acquired CellPoint and AboundBio in order to develop a cell therapy, which is a potential transformative treatment of different types of cancer.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Favorable Safety Profile: Throughout the 24-week treatment period, GLPG3667 demonstrated a safety and tolerability profile consistent with previous studies, which may enhance its competitive positioning in the market.
- Strategic Evaluation: Galapagos is exploring all strategic alternatives, including resuming partnership discussions to accelerate the development of GLPG3667 in dermatomyositis and other severe autoimmune diseases, indicating the company's commitment to this drug.
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Analyst Reactions: Analysts may respond to the stock reaching the target price by either downgrading their valuation or raising their target price, depending on the company's fundamental developments.
Diverse Analyst Targets: Within the Zacks coverage universe, analyst targets for GLPG vary significantly, with one as low as $22.00 and another as high as $40.50, indicating a standard deviation of $7.921.
Investor Considerations: The crossing of the average target price signals investors to evaluate whether the stock is on track for higher targets or if it has become overvalued, prompting potential profit-taking.
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- Strategic Implications: This acquisition will not only increase Vistra's asset base but also enhance operational efficiency and market share through the integration of Cogentrix's resources and technologies, driving long-term profitability.
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- Positive Stock Reaction: In after-hours trading, Microchip's shares rose 3.2% to $69.20, reflecting investor optimism regarding the company's improved performance, which may further enhance market interest in its stock.
- Enhanced Market Competitiveness: With the sales guidance upgrade, Microchip solidifies its competitive position in the semiconductor industry, particularly in rapidly evolving technology sectors, attracting more investor attention.
- Upcoming Earnings Report: The company is set to release its earnings report after market close, with analysts expecting earnings of $1.04 per share and revenue of $761.13 million, providing investors with an opportunity to further assess the company's financial health.
See More
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- Clinical Trial Success: GLPG3667 demonstrated a statistically significant improvement in the Total Improvement Score (TIS) at a 150mg dose in the dermatomyositis study, achieving a p-value of 0.0848, which positions the drug as a promising new treatment option.
- Favorable Safety Profile: Throughout the 24-week treatment period, GLPG3667 exhibited a safety and tolerability profile consistent with previous studies, enhancing its competitive edge in the market.
- Strategic Evaluation: Galapagos is exploring all strategic alternatives, including resuming partnership discussions to accelerate the development of GLPG3667 in dermatomyositis and other autoimmune diseases, indicating the company's commitment to this drug.
- Future Outlook: The company plans to present data at an upcoming medical conference, further advancing the clinical development of GLPG3667 to meet the urgent market demand for effective treatments.
See More
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- Clinical Trial Success: GLPG3667 achieved a statistically significant improvement in the Total Improvement Score (TIS) in the GALARISSO study for dermatomyositis at a 150mg dose (p=0.0848), establishing its potential as a new treatment option.
- Favorable Safety Profile: Throughout the 24-week treatment period, GLPG3667 demonstrated a safety and tolerability profile consistent with previous studies, which may enhance its competitive positioning in the market.
- Strategic Evaluation: Galapagos is exploring all strategic alternatives, including resuming partnership discussions to accelerate the development of GLPG3667 in dermatomyositis and other severe autoimmune diseases, indicating the company's commitment to this drug.
- Future Outlook: The company plans to present data at an upcoming medical conference, aiming to further analyze the long-term effects of GLPG3667, potentially providing more treatment options for patients.
See More
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Phase 3 Study Results: Galapagos NV's selective TYK2 inhibitor, GLPG3667, successfully met its primary endpoint in a phase 3-enabling study for dermatomyositis, showing significant clinical benefits compared to placebo.
Lupus Study Outcome: A second phase 3-enabling study of GLPG3667 for lupus did not meet its primary endpoint, prompting the company to explore strategic options for further development.
Future Plans: The company plans to resume partnering discussions to accelerate the development of GLPG3667 for dermatomyositis following the positive results from the GALARISSO study.
Market Reaction: Following the announcement, Galapagos shares experienced a decline of approximately 3.6% in after-hours trading.
See More
GLPG Surpasses Average Analyst Expectations
Current Stock Performance: Galapagos NV (GLPG) shares have recently surpassed the average analyst 12-month target price of $32.50, trading at $32.57 per share.
Analyst Reactions: Analysts may respond to the stock reaching the target price by either downgrading their valuation or raising their target price, depending on the company's fundamental developments.
Diverse Analyst Targets: Within the Zacks coverage universe, analyst targets for GLPG vary significantly, with one as low as $22.00 and another as high as $40.50, indicating a standard deviation of $7.921.
Investor Considerations: The crossing of the average target price signals investors to evaluate whether the stock is on track for higher targets or if it has become overvalued, prompting potential profit-taking.
See More
