Galapagos Decides to Wind Down Cell Therapy Activities
Galapagos announced that the works council consultation process regarding the wind-down of cell therapy activities has been completed and its board of directors has decided to initiate the wind-down of the company's cell therapy activities. On October 21, 2025, Galapagos announced its intention to wind down its cell therapy activities following a review and sale process, including an exploration of potential divestment options. This decision was subject to the conclusion of consultations with works councils in Belgium and the Netherlands, which have now been completed. "We have now concluded the works council consultation process regarding our intention to wind down the Company's cell therapy activities. We thank our dedicated colleagues for their commitment during this time of uncertainty as we now turn to executing the wind-down," said Henry Gosebruch, CEO of Galapagos. "As we move forward, we will seek to continue the evolution of Galapagos through transformative business development." The wind-down will impact approximately 365 employees across Europe, the U.S. and China, and will result in the closure of the sites in Leiden, Basel, Princeton, Pittsburgh and Shanghai.
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- Clinical Trial Success: GLPG3667 demonstrated a statistically significant improvement in the Total Improvement Score (TIS) at a 150mg dose in the dermatomyositis study, achieving a p-value of 0.0848, which positions the drug as a promising new treatment option.
- Favorable Safety Profile: Throughout the 24-week treatment period, GLPG3667 exhibited a safety and tolerability profile consistent with previous studies, enhancing its competitive edge in the market.
- Strategic Evaluation: Galapagos is exploring all strategic alternatives, including resuming partnership discussions to accelerate the development of GLPG3667 in dermatomyositis and other autoimmune diseases, indicating the company's commitment to this drug.
- Future Outlook: The company plans to present data at an upcoming medical conference, further advancing the clinical development of GLPG3667 to meet the urgent market demand for effective treatments.

- Clinical Trial Success: GLPG3667 achieved a statistically significant improvement in the Total Improvement Score (TIS) in the GALARISSO study for dermatomyositis at a 150mg dose (p=0.0848), establishing its potential as a new treatment option.
- Favorable Safety Profile: Throughout the 24-week treatment period, GLPG3667 demonstrated a safety and tolerability profile consistent with previous studies, which may enhance its competitive positioning in the market.
- Strategic Evaluation: Galapagos is exploring all strategic alternatives, including resuming partnership discussions to accelerate the development of GLPG3667 in dermatomyositis and other severe autoimmune diseases, indicating the company's commitment to this drug.
- Future Outlook: The company plans to present data at an upcoming medical conference, aiming to further analyze the long-term effects of GLPG3667, potentially providing more treatment options for patients.

Phase 3 Study Results: Galapagos NV's selective TYK2 inhibitor, GLPG3667, successfully met its primary endpoint in a phase 3-enabling study for dermatomyositis, showing significant clinical benefits compared to placebo.
Lupus Study Outcome: A second phase 3-enabling study of GLPG3667 for lupus did not meet its primary endpoint, prompting the company to explore strategic options for further development.
Future Plans: The company plans to resume partnering discussions to accelerate the development of GLPG3667 for dermatomyositis following the positive results from the GALARISSO study.
Market Reaction: Following the announcement, Galapagos shares experienced a decline of approximately 3.6% in after-hours trading.
Current Stock Performance: Galapagos NV (GLPG) shares have recently surpassed the average analyst 12-month target price of $32.50, trading at $32.57 per share.
Analyst Reactions: Analysts may respond to the stock reaching the target price by either downgrading their valuation or raising their target price, depending on the company's fundamental developments.
Diverse Analyst Targets: Within the Zacks coverage universe, analyst targets for GLPG vary significantly, with one as low as $22.00 and another as high as $40.50, indicating a standard deviation of $7.921.
Investor Considerations: The crossing of the average target price signals investors to evaluate whether the stock is on track for higher targets or if it has become overvalued, prompting potential profit-taking.







