Evaxion Expands AI-Immunology Platform to Autoimmune Diseases
Evaxion will expand the use of its proprietary AI-Immunology platform to also discover and develop new treatments for autoimmune diseases. Thus, Evaxion will in the future work within cancers, infectious and autoimmune diseases as its core disease areas. "Autoimmune diseases can be severely debilitating and even lethal, placing a substantial burden on patients, their families and on society across all stages of life. With AI-Immunology we have a unique technology and a platform that we know can deliver new treatment opportunities. By expanding the platform into autoimmune diseases, we have the potential to meaningfully improve the outcome for patients and unlock significant partnership value from the platform," says Helen Tayton-Martin, CEO at Evaxion.
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Evaxion Looks for New Partner for Gonorrhea Vaccine Following Merck's Withdrawal
Merck's Decision on EVX-B2: Merck & Co. has opted not to pursue Evaxion's gonorrhea vaccine candidate EVX-B2, allowing Evaxion to retain global rights and seek other licensing partners.
Gonorrhea Vaccine Landscape: Despite affecting over 80 million people annually, no gonorrhea vaccine has been approved yet, although preclinical studies show promise for EVX-B2.
Evaxion's Financial Outlook: Evaxion's CEO stated that Merck's decision does not impact their financial projections, which extend to the second half of 2027.
Recent Developments: Evaxion has successfully out-licensed another vaccine candidate, EVX-B3, to Merck, receiving an upfront payment and potential future milestone payments, while the FDA recently approved GSK's oral treatment for gonorrhea.
Evaxion Retains Global Rights to EVX-B2 After MSD Declines Option
- Change in Partnership Opportunity: MSD's decision not to exercise its option for Evaxion's Gonorrhea vaccine candidate EVX-B2 allows Evaxion to seek new licensing partners while retaining global rights to the project, although this decision does not impact its cash runway.
- Vaccine Potential: EVX-B2 has demonstrated protective effects against Gonorrhea in preclinical studies, highlighting the potential of Evaxion's AI-Immunology™ platform to develop vaccines that address significant unmet medical needs, despite the absence of approved vaccines to date.
- Financial Stability: Evaxion's cash flow outlook did not include a potential in-licensing of EVX-B2 by MSD, meaning this decision will not affect its cash runway, which is projected to extend into the second half of 2027, ensuring financial flexibility for future R&D activities.
- R&D Direction: Evaxion is also developing an mRNA version of EVX-B2 in collaboration with Afrigen Biologics, further expanding its vaccine pipeline and demonstrating the company's ongoing innovation capabilities in addressing infectious diseases.
Evaxion Retains Global Rights to EVX-B2 After MSD Declines Option
- Change in Partnership Opportunities: MSD's decision not to exercise its option for Evaxion's Gonorrhea vaccine candidate EVX-B2 allows Evaxion to seek new partners while retaining global rights, although this decision does not impact its cash flow outlook.
- Vaccine Potential: EVX-B2 has demonstrated protective effects against Gonorrhea in preclinical studies, and despite the absence of an approved vaccine, its success could address a significant unmet medical need, enhancing Evaxion's position in vaccine development.
- Financial Stability: Evaxion's cash runway remains unaffected by MSD's decision, extending into the second half of 2027, which ensures continued investment in vaccine development without immediate financial pressure.
- Technological Innovation: Evaxion is also developing an mRNA version of EVX-B2 in collaboration with Afrigen Biologics, further expanding its vaccine candidate pipeline and showcasing its technological capabilities and market adaptability under the AI-Immunology™ platform.
Evaxion Unveils EVX-04 Cancer Vaccine, Significantly Inhibiting Tumor Growth
- Vaccine Development Progress: Evaxion's EVX-04 vaccine successfully induces specific T-cell responses and effectively inhibits tumor growth in preclinical models, demonstrating its potential to improve treatment options for acute myeloid leukemia (AML) patients.
- Broad Antigen Coverage: The vaccine identifies and selects 16 non-conventional endogenous retrovirus (ERV) tumor antigen fragments through the AI-Immunology™ platform, ensuring broad coverage across different patients' tumors, thereby enhancing the likelihood of immune recognition.
- Market Demand Alignment: As AML is characterized by high mortality rates and limited existing treatment options, the introduction of EVX-04 not only addresses the urgent need for new therapies but also presents significant commercial opportunities for Evaxion.
- Innovative Technology Application: The
Evaxion Unveils EVX-04 Cancer Vaccine, Prevents Tumor Growth
- Robust Immune Response: Evaxion's EVX-04 cancer vaccine successfully induces specific T-cell responses and significantly prevents tumor growth in preclinical models, indicating its potential value for acute myeloid leukemia (AML) patients.
- Broad Applicability: Developed using the AI-Immunology™ platform, the vaccine targets non-conventional endogenous retrovirus (ERV) tumor antigens, ensuring extensive tumor coverage and applicability across various hard-to-treat cancers, addressing the urgent market need for new therapies.
- Data-Driven Target Selection: By analyzing genomic data from AML patients, EVX-04 selects 16 optimal ERV antigen fragments from five million, ensuring immune recognition and enhancing therapeutic efficacy.
- Immediate Use Vaccine Concept: As an off-the-shelf vaccine, EVX-04 is ready for immediate administration post-diagnosis, aiming to improve treatment options for AML patients and meet the significant unmet medical needs in current treatment modalities.
Post-Market Highlights: Jasper, NRx, Unicycive, Spruce, Evaxion, Solana, and Protara See Gains After Trading Hours
Biotech Gains in After-Hours Trading: Several biotechnology and pharmaceutical companies saw significant stock price increases in after-hours trading, driven by corporate updates and upcoming events.
Jasper Therapeutics' Webinar Announcement: Jasper Therapeutics, Inc. experienced a 21.51% surge after announcing a webinar to discuss findings from the BEACON study and preliminary data from the ETESIAN study.
NRx Pharmaceuticals' Presentation at NobleCon21: NRx Pharmaceuticals, Inc. rose 13.39% following the announcement that its CEO will present updates on the company's focus and clinical revenue at an upcoming conference.
Protara Therapeutics' Conference Call: Protara Therapeutics, Inc. gained 5.04% after revealing plans for a conference call to discuss interim data from its Phase 2 trial for bladder cancer, with findings to be presented at a major urology meeting.
Evaxion Looks for New Partner for Gonorrhea Vaccine Following Merck's Withdrawal
Merck's Decision on EVX-B2: Merck & Co. has opted not to pursue Evaxion's gonorrhea vaccine candidate EVX-B2, allowing Evaxion to retain global rights and seek other licensing partners.
Gonorrhea Vaccine Landscape: Despite affecting over 80 million people annually, no gonorrhea vaccine has been approved yet, although preclinical studies show promise for EVX-B2.
Evaxion's Financial Outlook: Evaxion's CEO stated that Merck's decision does not impact their financial projections, which extend to the second half of 2027.
Recent Developments: Evaxion has successfully out-licensed another vaccine candidate, EVX-B3, to Merck, receiving an upfront payment and potential future milestone payments, while the FDA recently approved GSK's oral treatment for gonorrhea.
Evaxion Retains Global Rights to EVX-B2 After MSD Declines Option
- Change in Partnership Opportunity: MSD's decision not to exercise its option for Evaxion's Gonorrhea vaccine candidate EVX-B2 allows Evaxion to seek new licensing partners while retaining global rights to the project, although this decision does not impact its cash runway.
- Vaccine Potential: EVX-B2 has demonstrated protective effects against Gonorrhea in preclinical studies, highlighting the potential of Evaxion's AI-Immunology™ platform to develop vaccines that address significant unmet medical needs, despite the absence of approved vaccines to date.
- Financial Stability: Evaxion's cash flow outlook did not include a potential in-licensing of EVX-B2 by MSD, meaning this decision will not affect its cash runway, which is projected to extend into the second half of 2027, ensuring financial flexibility for future R&D activities.
- R&D Direction: Evaxion is also developing an mRNA version of EVX-B2 in collaboration with Afrigen Biologics, further expanding its vaccine pipeline and demonstrating the company's ongoing innovation capabilities in addressing infectious diseases.
Evaxion Retains Global Rights to EVX-B2 After MSD Declines Option
- Change in Partnership Opportunities: MSD's decision not to exercise its option for Evaxion's Gonorrhea vaccine candidate EVX-B2 allows Evaxion to seek new partners while retaining global rights, although this decision does not impact its cash flow outlook.
- Vaccine Potential: EVX-B2 has demonstrated protective effects against Gonorrhea in preclinical studies, and despite the absence of an approved vaccine, its success could address a significant unmet medical need, enhancing Evaxion's position in vaccine development.
- Financial Stability: Evaxion's cash runway remains unaffected by MSD's decision, extending into the second half of 2027, which ensures continued investment in vaccine development without immediate financial pressure.
- Technological Innovation: Evaxion is also developing an mRNA version of EVX-B2 in collaboration with Afrigen Biologics, further expanding its vaccine candidate pipeline and showcasing its technological capabilities and market adaptability under the AI-Immunology™ platform.
Evaxion Unveils EVX-04 Cancer Vaccine, Significantly Inhibiting Tumor Growth
- Vaccine Development Progress: Evaxion's EVX-04 vaccine successfully induces specific T-cell responses and effectively inhibits tumor growth in preclinical models, demonstrating its potential to improve treatment options for acute myeloid leukemia (AML) patients.
- Broad Antigen Coverage: The vaccine identifies and selects 16 non-conventional endogenous retrovirus (ERV) tumor antigen fragments through the AI-Immunology™ platform, ensuring broad coverage across different patients' tumors, thereby enhancing the likelihood of immune recognition.
- Market Demand Alignment: As AML is characterized by high mortality rates and limited existing treatment options, the introduction of EVX-04 not only addresses the urgent need for new therapies but also presents significant commercial opportunities for Evaxion.
- Innovative Technology Application: The
Evaxion Unveils EVX-04 Cancer Vaccine, Prevents Tumor Growth
- Robust Immune Response: Evaxion's EVX-04 cancer vaccine successfully induces specific T-cell responses and significantly prevents tumor growth in preclinical models, indicating its potential value for acute myeloid leukemia (AML) patients.
- Broad Applicability: Developed using the AI-Immunology™ platform, the vaccine targets non-conventional endogenous retrovirus (ERV) tumor antigens, ensuring extensive tumor coverage and applicability across various hard-to-treat cancers, addressing the urgent market need for new therapies.
- Data-Driven Target Selection: By analyzing genomic data from AML patients, EVX-04 selects 16 optimal ERV antigen fragments from five million, ensuring immune recognition and enhancing therapeutic efficacy.
- Immediate Use Vaccine Concept: As an off-the-shelf vaccine, EVX-04 is ready for immediate administration post-diagnosis, aiming to improve treatment options for AML patients and meet the significant unmet medical needs in current treatment modalities.
Post-Market Highlights: Jasper, NRx, Unicycive, Spruce, Evaxion, Solana, and Protara See Gains After Trading Hours
Biotech Gains in After-Hours Trading: Several biotechnology and pharmaceutical companies saw significant stock price increases in after-hours trading, driven by corporate updates and upcoming events.
Jasper Therapeutics' Webinar Announcement: Jasper Therapeutics, Inc. experienced a 21.51% surge after announcing a webinar to discuss findings from the BEACON study and preliminary data from the ETESIAN study.
NRx Pharmaceuticals' Presentation at NobleCon21: NRx Pharmaceuticals, Inc. rose 13.39% following the announcement that its CEO will present updates on the company's focus and clinical revenue at an upcoming conference.
Protara Therapeutics' Conference Call: Protara Therapeutics, Inc. gained 5.04% after revealing plans for a conference call to discuss interim data from its Phase 2 trial for bladder cancer, with findings to be presented at a major urology meeting.
