BriaCell showcases Bria-OTS's anti-cancer effects at SITC 2025
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 07 2025
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Should l Buy BCTX?
Presentation Announcement: BriaCell Therapeutics will present evidence of its Bria-OTS+ platform's immune engagement and anti-cancer activity at the SITC Annual Meeting in November 2025.
Preclinical Findings: The Bria-BRES+ and Bria-PROS+ candidates demonstrated rapid activation of the immune system and induced sustained anti-cancer responses in preclinical models.
Clinical Implications: The findings suggest potential for prolonged clinical benefits for patients treated with the Bria-OTS+ platform, indicating its effectiveness in whole cell immunotherapies.
Future Expansion: Positive results from the lead candidates support the broad applicability of the Bria-OTS+ platform and the possibility of expanding into other solid tumor indications.
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Analyst Views on BCTX
About BCTX
BriaCell Therapeutics Corp. is a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care. Bria-IMT, its Phase 3 lead candidate, is a patented, off-the-shelf, cell-based, targeted immunotherapy that activates the patient’s immune system to specifically kill cancer cells without harming other cells. The Company is advancing its Bria-IMT targeted immunotherapy in combination with an immune check point inhibitor (Retifanlimab) in a pivotal Phase 3 study in metastatic breast cancer. It is also developing personalized off-the-shelf immunotherapies, Bria-OTS and Bria-OTS+, which provides a platform technology to develop personalized off-the-shelf immunotherapies for numerous types of cancer, and a soluble CD80 protein therapeutic which act both as a stimulator of the immune system, as well as an immune checkpoint inhibitor. Its pipeline also includes Bria-IMT + CPI, Bria-BRES/BRES+, Bria-PROS+, Bria-LUNG+ and Bria-MEL+.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Evidence of Immune Activation: CD8 ImmunoPET imaging revealed a significant increase in CD8+ T cells in the cervical lymph nodes post-Bria-IMT treatment, indicating immune system activation that may contribute to long-term survival.
- Study Scale and Results: Among 54 heavily pre-treated metastatic breast cancer patients, 37 received the Bria-IMT regimen, with no reported treatment discontinuations related to Bria-IMT to date, indicating good safety and tolerability of the therapy.
- Future Research Prospects: The ongoing Phase 3 clinical trial (NCT06072612) by BriaCell will further validate the efficacy of Bria-IMT, potentially bringing new hope to cancer treatment.
See More
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- Strong Treatment Continuity: No Bria-IMT-related discontinuations have been reported to date, suggesting good tolerability of the regimen among patients, which may provide new treatment options for heavily pre-treated individuals.
- Clinical Trial Progress: The Bria-IMT regimen continues under Fast Track Designation from the US FDA, expected to offer more effective treatment options for late-stage breast cancer patients, addressing the urgent market need for new therapies.
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See More
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- Warrant Information: Each unit consists of one common share and one warrant, the latter allowing purchase of common shares at an exercise price of $6.93, expiring five years post-issuance, enhancing potential returns for investors.
- Stock Price Impact: Following the announcement, BCTX's stock plummeted 54.12% to $5.01, reflecting a highly negative market reaction despite a previous surge to $12.10 due to positive results in treating breast cancer patients.
- Future Trading Arrangements: The warrants have been approved for listing on the Nasdaq Capital Market, expected to begin trading under the symbol
See More
