Biotech Stocks Rise After Hours Following Trial News and Strategic Developments
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Sep 24 2025
0mins
Should l Buy CYCN?
Source: NASDAQ.COM
Cyclerion Therapeutics Surge: Cyclerion Therapeutics, Inc. (CYCN) saw a 48.01% increase in after-hours trading after announcing a strategic relaunch focused on neuropsychiatric therapies, including a licensing agreement with MIT for its treatment-resistant depression program, with a Phase 2 trial expected to start in 2026.
Clearside Biomedical Updates: Clearside Biomedical Inc. (CLSD) rose 6.82% in after-hours trading following presentations at the EURETINA Congress regarding its Phase 2b trial for wet age-related macular degeneration, with the next key milestone being the initiation of a Phase 3 trial.
Reviva Pharmaceuticals Conference Participation: Reviva Pharmaceuticals Holdings Inc. (RVPH) experienced an 11.50% rise in after-hours trading ahead of its participation in the Lytham Partners Fall 2025 Investor Conference, despite a decline during regular trading hours.
Corcept Therapeutics Data Presentation: Corcept Therapeutics Inc. (CORT) gained 4.54% in after-hours trading and announced it will present late-breaking data from its Phase 3 trial for relacorilant in ovarian cancer at the 2025 ESMO Annual Meeting, with key PDUFA dates set for late 2025 and mid-2026.
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Analyst Views on CYCN
About CYCN
Cyclerion Therapeutics, Inc. is a biopharmaceutical company dedicated to identifying, developing, and delivering therapies for central nervous system (CNS) diseases. The Company is focused on building a pipeline with therapeutics to treat certain neuropsychiatric diseases. It is focused on an individualized therapy for treatment-resistant depression (TRD) - a condition with significant unmet medical need. Its assets include Olinciguat and Praliciguat. The Company has entered into an exclusive license option agreement for its vascular soluble guanylate cyclase (sGC) stimulator, olinciguat. Praliciguat is an oral, once-daily, systemic sGC stimulator that is licensed to Akeibia Therapeutics, Inc and is being advanced in rare kidney disease.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
AZZ Inc Reports Q3 Earnings Beat, Shares Rise 2.1%
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- Sales Growth: The company achieved sales of $425.746 million, exceeding expectations of $418.164 million, demonstrating strong market demand and further solidifying its position in the industry.
- Stock Price Surge: In pre-market trading, AZZ Inc shares rose 2.1% to $112.09, reflecting a positive market reaction to its earnings report, which could boost investor confidence in subsequent trading days.
- Optimistic Market Outlook: With improved performance, AZZ Inc is poised to continue attracting investment and enhancing its competitive edge, particularly in the context of the current economic recovery.
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- Market Reaction: Following the announcement, shares skyrocketed to $19.30, reflecting a positive investor response to the clinical data, which may attract more institutional investors and further enhance the company's market capitalization.
- Industry Impact: Alumis's success provides a new treatment option in the biopharmaceutical industry, particularly in the psoriasis sector, potentially prompting other companies to increase R&D investments and drive overall industry innovation.
- Future Outlook: With the successful clinical trials, Alumis is expected to accelerate the drug's market entry, likely leading to significant revenue growth while strengthening its position in the highly competitive biopharmaceutical market.
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- Earnings Beat: AngioDynamics reported an adjusted EPS of $0.00 for Q2, exceeding market expectations of a 10-cent loss, indicating a significant improvement in the company's profitability.
- Sales Growth: The company achieved sales of $79.4 million, surpassing the market forecast of $76.3 million, demonstrating strong product demand and driving overall performance enhancement.
- Positive Market Reaction: Following the earnings release, AngioDynamics' stock received favorable attention from investors, reflecting confidence in its future growth potential, which may further drive stock price appreciation.
- Optimistic Industry Outlook: With the recovery of the medical device sector, AngioDynamics' robust performance could attract more investor interest, strengthening its position in a competitive market.
See More
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- Exclusive Collaboration Agreement: Cyclerion Therapeutics has signed an application-specific exclusive collaboration with Medsteer, aiming to integrate Medsteer's closed-loop anesthetic delivery systems with Cyclerion's CYC-126 program, thereby enhancing clinical development efficiency for treatment-resistant depression.
- Clinical Trial Plans: Cyclerion plans to initiate a Phase 2 Proof of Concept clinical trial for CYC-126 in the second half of 2026, which is expected to provide personalized treatment for approximately 3 million Americans suffering from treatment-resistant depression, significantly improving patient quality of life.
- Positive Market Reaction: Following the announcement of the collaboration, CYCN's stock surged 47.10% in premarket trading to $2.03, reflecting strong market recognition of the collaboration's potential, which may drive future financing and growth for the company.
- Technology Integration Progress: Cyclerion will leverage its neuropsychiatric and clinical development expertise to strengthen the integration with Medsteer's technology, with device integration expected to be completed in 2026, laying a solid foundation for subsequent clinical trials.
See More
Cyclerion Therapeutics Expands Collaboration with Medsteer, Shares Surge 44.2%
- Significant Stock Surge: Cyclerion Therapeutics shares rose 44.2% to $1.99 in pre-market trading, reflecting strong market confidence in the company's expanded strategic collaboration with Medsteer, indicating positive investor sentiment towards future growth prospects.
- Deepening Strategic Collaboration: The partnership with Medsteer aims to advance the closed-loop anesthetic platform CYC-126, which is expected to accelerate the product's market entry, thereby enhancing the company's competitive edge in the anesthesia sector.
- Optimistic Market Outlook: With continuous advancements in anesthetic technology, Cyclerion's new platform is poised to meet the increasing medical demand, further driving revenue growth and strengthening its position in the healthcare industry.
- Increased Investor Confidence: The substantial stock price increase not only reflects market approval of the company's strategic direction but may also attract more investor interest, thereby supporting future financing and expansion efforts.
See More
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Contract Announcement: Cycurion, Inc. has secured a contract with a major telecommunications company to provide network deployment services for a federal agency's modernization initiative, covering over 1,300 sites nationwide.
Project Details: The project, valued at over $1 million, aims to replace outdated infrastructure with a modern communication network, enhancing emergency warning capabilities over a duration of 24 to 36 months.
Recent Achievements: Cycurion also recently won a $1.145 million contract to modernize data systems for a large county public guardian office, migrating sensitive data to a secure Microsoft SQL Server platform.
Stock Performance: Following these announcements, Cycurion's stock rose by 2.08% to $2.45, although it remains near its 52-week low of $2.15.
See More
AZZ Inc Reports Q3 Earnings Beat, Shares Rise 2.1%
- Earnings Beat: AZZ Inc reported adjusted earnings of $1.52 per share for Q3, surpassing market expectations of $1.47, indicating sustained profitability that may attract more investor interest.
- Sales Growth: The company achieved sales of $425.746 million, exceeding expectations of $418.164 million, demonstrating strong market demand and further solidifying its position in the industry.
- Stock Price Surge: In pre-market trading, AZZ Inc shares rose 2.1% to $112.09, reflecting a positive market reaction to its earnings report, which could boost investor confidence in subsequent trading days.
- Optimistic Market Outlook: With improved performance, AZZ Inc is poised to continue attracting investment and enhancing its competitive edge, particularly in the context of the current economic recovery.
See More
Alumis Inc. Shares Surge 132% After Successful Phase 3 Trial Results
- Trial Success: Alumis Inc. achieved all primary and secondary endpoints in its Phase 3 ONWARD1 and ONWARD2 trials for envudeucitinib in moderate-to-severe plaque psoriasis, resulting in a 132% surge in stock price, indicating strong market potential and investor confidence.
- Market Reaction: Following the announcement, shares skyrocketed to $19.30, reflecting a positive investor response to the clinical data, which may attract more institutional investors and further enhance the company's market capitalization.
- Industry Impact: Alumis's success provides a new treatment option in the biopharmaceutical industry, particularly in the psoriasis sector, potentially prompting other companies to increase R&D investments and drive overall industry innovation.
- Future Outlook: With the successful clinical trials, Alumis is expected to accelerate the drug's market entry, likely leading to significant revenue growth while strengthening its position in the highly competitive biopharmaceutical market.
See More
AngioDynamics Surpasses Expectations with $79.4M Sales and Break-Even EPS
- Earnings Beat: AngioDynamics reported an adjusted EPS of $0.00 for Q2, exceeding market expectations of a 10-cent loss, indicating a significant improvement in the company's profitability.
- Sales Growth: The company achieved sales of $79.4 million, surpassing the market forecast of $76.3 million, demonstrating strong product demand and driving overall performance enhancement.
- Positive Market Reaction: Following the earnings release, AngioDynamics' stock received favorable attention from investors, reflecting confidence in its future growth potential, which may further drive stock price appreciation.
- Optimistic Industry Outlook: With the recovery of the medical device sector, AngioDynamics' robust performance could attract more investor interest, strengthening its position in a competitive market.
See More
Cyclerion (CYCN) Enters Exclusive Collaboration with Medsteer to Advance CYC-126 Clinical Trials
- Exclusive Collaboration Agreement: Cyclerion Therapeutics has signed an application-specific exclusive collaboration with Medsteer, aiming to integrate Medsteer's closed-loop anesthetic delivery systems with Cyclerion's CYC-126 program, thereby enhancing clinical development efficiency for treatment-resistant depression.
- Clinical Trial Plans: Cyclerion plans to initiate a Phase 2 Proof of Concept clinical trial for CYC-126 in the second half of 2026, which is expected to provide personalized treatment for approximately 3 million Americans suffering from treatment-resistant depression, significantly improving patient quality of life.
- Positive Market Reaction: Following the announcement of the collaboration, CYCN's stock surged 47.10% in premarket trading to $2.03, reflecting strong market recognition of the collaboration's potential, which may drive future financing and growth for the company.
- Technology Integration Progress: Cyclerion will leverage its neuropsychiatric and clinical development expertise to strengthen the integration with Medsteer's technology, with device integration expected to be completed in 2026, laying a solid foundation for subsequent clinical trials.
See More
Cyclerion Therapeutics Expands Collaboration with Medsteer, Shares Surge 44.2%
- Significant Stock Surge: Cyclerion Therapeutics shares rose 44.2% to $1.99 in pre-market trading, reflecting strong market confidence in the company's expanded strategic collaboration with Medsteer, indicating positive investor sentiment towards future growth prospects.
- Deepening Strategic Collaboration: The partnership with Medsteer aims to advance the closed-loop anesthetic platform CYC-126, which is expected to accelerate the product's market entry, thereby enhancing the company's competitive edge in the anesthesia sector.
- Optimistic Market Outlook: With continuous advancements in anesthetic technology, Cyclerion's new platform is poised to meet the increasing medical demand, further driving revenue growth and strengthening its position in the healthcare industry.
- Increased Investor Confidence: The substantial stock price increase not only reflects market approval of the company's strategic direction but may also attract more investor interest, thereby supporting future financing and expansion efforts.
See More
Cycurion Secures Over $1 Million Contract to Upgrade Federal Emergency Warning System
Contract Announcement: Cycurion, Inc. has secured a contract with a major telecommunications company to provide network deployment services for a federal agency's modernization initiative, covering over 1,300 sites nationwide.
Project Details: The project, valued at over $1 million, aims to replace outdated infrastructure with a modern communication network, enhancing emergency warning capabilities over a duration of 24 to 36 months.
Recent Achievements: Cycurion also recently won a $1.145 million contract to modernize data systems for a large county public guardian office, migrating sensitive data to a secure Microsoft SQL Server platform.
Stock Performance: Following these announcements, Cycurion's stock rose by 2.08% to $2.45, although it remains near its 52-week low of $2.15.
See More
