Adlai Nortye to Discuss AN4035 Preclinical Findings at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Treatments
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 22 2025
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Should l Buy ANL?
Source: Newsfilter
Presentation Announcement: Adlai Nortye Ltd. will present its novel CEACAM5-targeting antibody-drug conjugate (ADC), AN4035, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston from October 22-26, 2025.
Key Findings: AN4035 showed strong cytotoxicity in specific cancer cell lines, achieved a 73% objective response rate in a patient-derived xenograft trial, and demonstrated a favorable toxicology profile in preclinical studies.
Therapeutic Potential: The ADC is designed to minimize systemic toxicities associated with current pan-RAS(ON) inhibitors, aiming to improve efficacy and broaden the therapeutic window for treating RAS-addicted tumors.
Company Overview: Adlai Nortye is a clinical-stage biotechnology company focused on innovative cancer therapies, with a portfolio that includes next-generation PD-1/L1 modulation and RAS-targeted therapies.
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About ANL
Adlai Nortye Ltd. is a Cayman Islands-based investment holding company. The Company is involved in the research and development of pharmaceutical products. It is a clinical-stage company focused on the development of targeted and immune-modulating cancer therapies. It is advancing an oncology pipeline, with Buparlisib (AN2025), a pan-phosphoinositide 3-kinase (PI3K) inhibitor, being evaluated in a registrational Phase three trial (NCT04338399) for patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC) that has progressed after prior anti-programmed death-ligand 1 (PD-L1) treatment. It is also advancing multiple drug candidates, including AN4005, an oral small molecule PD-L1 inhibitor; AN8025, a multifunctional fusion protein acting as a T cell and antigen-presenting cell (APC) modulator; and AN9025, an oral small molecule pan-rat sarcoma virus (RAS) inhibitor. The Company’s subsidiary, Alpine Bioscience Ltd. (Alpine BVI), is an investment holding company.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Significant Financing: Adlai Nortye announced a $140 million private placement equity financing, selling approximately 64.6 million Class A ordinary shares at $2.1667 each, indicating strong market confidence in its innovative therapies.
- Key Investor Support: The placement includes about $55 million of Class A shares sold to entities controlled by Chairman and CEO Yang Lu, demonstrating the management's strong belief in the company's future growth.
- Positive Stock Reaction: Following the financing announcement, Adlai Nortye's stock price surged approximately 25% in pre-market trading on Tuesday, reflecting investor optimism about the company's prospects and potentially attracting further interest.
- Strategic Implications: Yang Lu noted that this financing attracted a high-quality group of healthcare investors to support Adlai Nortye's innovative and potentially best-in-class RAS-targeting therapies, further solidifying the company's market position in the biopharmaceutical sector.
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- Key Investor Support: The placement includes about $55 million of Class A shares sold to entities controlled by Chairman and CEO Yang Lu, demonstrating the management's strong belief in the company's future growth.
- Positive Stock Reaction: Following the financing announcement, Adlai Nortye's stock price surged approximately 25% in pre-market trading on Tuesday, reflecting investor optimism about the company's prospects and potentially attracting further interest.
- Strategic Implications: Yang Lu noted that this financing attracted a high-quality group of healthcare investors to support Adlai Nortye's innovative and potentially best-in-class RAS-targeting therapies, further solidifying the company's market position in the biopharmaceutical sector.
See More
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- Stock Price Reaction: Following the disappointing delivery results, Xpeng's stock dropped 5.6% in pre-market trading to $16.97, reflecting concerns about the company's future performance among investors.
- Overall Market Trend: U.S. stock futures were lower, with Dow futures falling around 100 points, indicating a cautious market sentiment that could further impact investor attitudes towards Xpeng.
- Industry Impact: The delivery figures from Xpeng may negatively affect overall confidence in the electric vehicle market, especially in an increasingly competitive landscape, prompting investors to reassess their strategies.
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- Joint Venture Extension: SanDisk announced the extension of its joint venture with Japan's Kioxia Corp. until December 31, 2034, further solidifying their strategic partnership in storage technology and enhancing market competitiveness.
- Positive Market Reaction: The significant rise in stock price reflects investor optimism about the company's future prospects, which may also attract more institutional investors, thereby elevating the company's standing in the industry.
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- Spinoff Strategy: The spinoff aims to enhance Kunlunxin's independence and market valuation, which is expected to provide Baidu with more flexible capital operations and resource allocation, thereby strengthening its competitive position in the technology sector.
- Market Reaction: The spinoff news has sparked investor excitement, with the significant rise in Baidu's stock reflecting confidence in its future growth potential and likely attracting more institutional investors to its shares.
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