Artelo Biosciences Publishes New Study Showing SBFI103 Reduces Anxiety and Depression
Artelo Biosciences announced the publication of new peer-reviewed research from the laboratory of Dr. Steven Laviolette, Professor in the Schulich School of Medicine at the University of Western Ontario, Canada, partially funded by the Company, demonstrating that intraperitoneal administration of Artelo's proprietary FABP5 inhibitor SBFI103 produces robust anxiolytic and antidepressant-like effects in a validated preclinical model of chronic stress. The paper, titled "Inhibition of fatty acid binding protein 5 prevents stress-induced anxiogenic and depressive-like symptoms through modulation of hippocampal neurogenesis, cannabinoid and neurotrophic signaling in the limbic circuitry," was published in Neurobiology of Disease. Key Findings: The newly published study demonstrates that intraperitoneal administration of SBFI103 leads to significant: Reductions in anxiety- and depression-like behaviors in chronically stressed rats after a single dose, with no adverse impact on locomotion or memory; Increased gene expression of key receptors within the endocannabinoid system, including CB2, GPR55, and TRPV1, in the hippocampus; Prevention of stress-induced reductions in biomarkers associated with depression in the hippocampus; Blocking of the detrimental effects of chronic stress on hippocampal neurogenesis, a critical biological process linked to mood regulation and cognitive function
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Public Offering Announcement: Artelo Biosciences has initiated an underwritten public offering of its common stock and/or pre-funded warrants, with all shares being offered by the company.
Market Conditions Impact: The completion, final size, and terms of the offering are contingent on market conditions, and there is no assurance regarding the timing or completion of the offering.
Public Offering Announcement: Artelo Biosciences, Inc. has initiated an underwritten public offering of its common stock and/or pre-funded warrants, with the offering subject to market conditions and no assurance of completion or specific terms.
Company Overview: Artelo Biosciences is a clinical-stage pharmaceutical company focused on developing treatments for various conditions, including cancer and pain, by modulating lipid-signaling pathways, and is led by an experienced executive team.

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Public Offering Details: Artelo Biosciences, Inc. closed an underwritten public offering of 640,924 shares of common stock at $4.40 per share, along with pre-funded warrants for 40,894 shares at $4.399 each, raising approximately $3 million in gross proceeds.
Market Performance: Following the offering, Artelo's stock closed at $4.51, reflecting a 3.68% increase, with no after-hours trading activity reported on NasdaqCM.








