Alvotech Leadership Change: Robert Wessman to Step Down as CEO
Alvotech announced key senior leadership changes following a planned succession process. Founder Robert Wessman, who has served as Chairman since the company's inception in 2013 and CEO since 2023, will transition out of the CEO role at the end of the first quarter of 2026. He will continue to serve as Executive Chairman in a full-time capacity. Lisa Graver has been appointed as his successor as CEO. She served as CEOO of Alvogen until its acquisition by Lotus Pharmaceutical in December 2025, and as a member of Alvotech's Board since its public listing in 2022. The transition process will begin immediately, with Ms Graver working closely with Mr Wessman and the executive team over the coming months to ensure continuity and a smooth handover. Upon assuming the CEO role, she will step down from the Alvotech Board.
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- Securities Claims Investigation: Rosen Law Firm is investigating Alvotech (NASDAQ: ALVO) for potential securities claims due to allegations of issuing materially misleading business information, which has negatively impacted investor confidence and the company's reputation.
- Stock Price Plunge: Following the November 2, 2025 press release regarding its Biologics License Application, Alvotech's stock price plummeted 34% on November 3 and nearly 4% on November 4, indicating significant market concerns about its future prospects.
- Class Action Preparation: Rosen Law Firm is preparing a class action to recover losses for investors, with no out-of-pocket fees required, which may encourage more affected shareholders to participate in the legal proceedings.
- Law Firm's Strength: Known for its successful track record in securities class actions, Rosen Law Firm recovered over $438 million for investors in 2019 alone, demonstrating its expertise and resource advantages in handling similar cases.
- Clinical Trial Success: Alvotech's AVT80 biosimilar achieved primary endpoints in the AVT80-GL-P01 trial, demonstrating pharmacokinetic similarity to Takeda's Entyvio, which is expected to enhance its competitiveness in the bowel disease treatment market.
- Significant Market Potential: With Entyvio generating $6.4 billion in global net revenue last year, Alvotech's success could capture substantial market share, especially as biosimilars gain increasing attention in the pharmaceutical landscape.
- Positive Regulatory Feedback: Regulatory feedback indicates that the AVT80-GL-P01 trial results meet expectations, confirming pharmacokinetic similarity for AVT80 and AVT16 in subcutaneous and intravenous administration, laying a solid foundation for future market applications.
- Positive Stock Reaction: Following the announcement, Alvotech shares spiked approximately 3% in premarket trading, reflecting investor optimism regarding the biosimilar's prospects, which may further drive the company's financing and expansion plans.
- Positive Study Results: Alvotech announced that its biosimilar AVT80 met all primary endpoints in clinical trials, demonstrating good safety and tolerability, paving the way for regulatory submissions.
- Strong Market Reaction: Following the announcement of positive pharmacokinetic study results, Alvotech's shares surged nearly 10% in pre-market trading on Thursday, reflecting investor optimism about the biosimilar's prospects.
- Significant Market Potential: With Entyvio's projected global net revenue of $6.4 billion in 2025, Alvotech's AVT80, if successfully launched, stands to capture a substantial share of this lucrative market.
- Extensive Industry Partnerships: Alvotech has established collaborations with multiple global pharmaceutical companies, including Teva and Cipla, showcasing its strong network and influence in the biosimilar market.
- Clinical Trial Success: Alvotech's AVT80 pharmacokinetic study met all primary endpoints compared to Entyvio, indicating PK similarity in healthy adults and paving the way for regulatory submissions.
- Robust Study Design: The randomized, double-blind, single-dose, parallel-group study utilized a 108 mg/0.68 mL subcutaneous injection, ensuring reliable safety, tolerability, and immunogenicity data, thereby enhancing market competitiveness.
- Significant Market Potential: With Entyvio generating approximately $6.4 billion in global net revenues in 2025, AVT80, as its biosimilar candidate, is expected to capture market share and drive revenue growth for Alvotech.
- Strategic Development Focus: The successful clinical trial not only demonstrates Alvotech's capabilities in biosimilar development but also provides crucial support for the clinical similarity of AVT16 and AVT80, further solidifying its position in the global biopharmaceutical market.
- Securities Claims Investigation: Rosen Law Firm is investigating potential securities claims against Alvotech (NASDAQ: ALVO) for allegedly issuing materially misleading business information, indicating that affected shareholders may be entitled to compensation without any out-of-pocket costs.
- Significant Stock Decline: Following a press release on November 2, 2025, regarding a complete response letter from the FDA on its Biologics License Application, Alvotech's stock plummeted 34% on November 3 and nearly 4% on November 4, reflecting investor concerns about the company's future prospects.
- Class Action Preparation: The firm is preparing a class action to recover investor losses, encouraging affected investors to join through their website or by phone, highlighting their commitment to protecting investor rights in the face of potential misconduct.
- Firm's Track Record: Rosen Law Firm specializes in securities class actions and has recovered over $438 million for investors in 2019 alone, showcasing their expertise and success in the field, which is crucial for investors when selecting legal counsel for such matters.
- Agreement Signing: Alvotech has entered into supply and commercialization agreements with Sandoz covering multiple biosimilar candidates in Canada, Australia, and New Zealand, marking a significant step in Alvotech's global market expansion.
- Clear Responsibility Allocation: Under the agreement, Sandoz will handle regulatory submissions, commercialization, and distribution in their respective regions, while Alvotech retains responsibility for development, global clinical activities, and manufacturing, ensuring product quality and supply chain stability.
- Product Segmentation: In Canada, the agreement includes one ophthalmology biosimilar candidate supplied as a prefilled syringe for intravitreal injection; in Australia and New Zealand, it encompasses three biosimilar candidates in immunology and gastroenterology, showcasing Alvotech's strategic positioning across multiple therapeutic areas.
- Market Dynamics: Sandoz is currently trading at 60.72 Swiss francs, down 0.75%, reflecting market attention on the biosimilars sector and investor expectations regarding the new collaboration.











