Adial Pharmaceuticals Announces International Patent Application for AD04
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 14 2026
0mins
Should l Buy ADIL?
Adial Pharmaceuticals announced the publication of the international patent application for AD04, filed in July 2024. AD04 is the Company's lead investigational genetically targeted serotonin-3 receptor antagonist therapeutic agent for the treatment of Alcohol Use Disorder in heavy drinking patients. The patent, once granted, is expected to protect Adial's core assets through at least 2045. Cary Claiborne, President and Chief Executive Officer of Adial, commented, "As we continue to advance the AD04 program with planning for the next phase of our clinical program, the new patent application and its expected approval will extend protection of the core assets of Adial out to at least 2045. This application is the result of an extensive examination of data and information which occurred after Adial hired new patent counsel to bolster and leverage Adial's intellectual property portfolio."
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Analyst Views on ADIL
Wall Street analysts forecast ADIL stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for ADIL is 1.50 USD with a low forecast of 1.50 USD and a high forecast of 1.50 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
1 Analyst Rating
1 Buy
0 Hold
0 Sell
Moderate Buy
Current: 3.425
Low
1.50
Averages
1.50
High
1.50
Current: 3.425
Low
1.50
Averages
1.50
High
1.50
About ADIL
Adial Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on the development of therapies for the treatment and prevention of addiction and related disorders. The Company’s lead investigational new drug product, AD04, is a genetically targeted, serotonin-3 receptor antagonist, therapeutic agent for the treatment of Alcohol Use Disorder (AUD) in heavy drinking patients and was recently investigated in the Company’s ONWARD pivotal Phase III clinical trial for the potential treatment of AUD in subjects with certain target genotypes identified using the Company’s proprietary companion diagnostic genetic test. AD04 is also used for the treatment of other addictive disorders, such as Opioid Use Disorder, obesity, smoking, and other drug addictions. The Company’s wholly owned subsidiary is Purnovate, Inc.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Market Performance: U.S. stocks traded lower this morning, with the Nasdaq Composite falling over 200 points and the S&P 500 down 0.74% to 6,831.80, indicating weakened market sentiment and heightened investor concerns about future economic prospects.
- Sector Dynamics: Consumer staples stocks gained 0.3%, while consumer discretionary stocks fell by 2.2%, reflecting a divergence in market confidence across different consumer sectors, which could impact short-term performance of related companies.
- Economic Data: U.S. job openings declined by 386,000 to 6.542 million in December, significantly below market estimates of 7.2 million, indicating a tightening labor market that may affect future economic growth expectations.
- Initial Jobless Claims: Initial jobless claims rose by 22,000 to 231,000, exceeding market expectations of 212,000, suggesting potential pressures on the labor market that could further impact consumer confidence and spending.
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- Mixed Market Performance: On Wednesday, the Nasdaq Composite fell over 400 points, down 1.87%, while the Dow rose 0.24%, highlighting a contrast between the weakness in tech stocks and relative strength in traditional sectors.
- Energy Stocks Rise: Energy shares gained 1.7% during Wednesday's trading, reflecting optimistic market expectations for energy demand, which could positively impact the profitability of related companies.
- Stable Economic Data: The ISM Services PMI remained at 53.8 in January, unchanged from December's revised reading, indicating stable growth in the services sector, which may support market confidence.
See More
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- Dow Jones Gains: On Wednesday, the Dow Jones index rose over 200 points, increasing by 0.44% to 49,459.82, indicating some optimism in the market despite mixed overall performance.
- NASDAQ and S&P 500 Decline: In contrast to the Dow's rise, the NASDAQ fell by 0.74% to 23,082.23, while the S&P 500 dropped 0.16% to 6,906.91, reflecting pressure on tech stocks and other sectors.
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- Legislative Support for New Therapies: The 2026 Appropriations Bill passed by Congress mandates collaboration between the FDA and NIDA to establish alternative clinical trial endpoints, emphasizing non-abstinence outcomes like reduced cravings, which is expected to enhance the regulatory pathway for Adial's AD04 therapy.
- Precision Medicine Strategy: Adial's investigational therapy AD04 is designed to treat Alcohol Use Disorder (AUD) using a precision medicine approach, aligning with the new legislation's focus on non-abstinence recovery goals, potentially accelerating clinical trial timelines and broadening clinical relevance.
- Public Health Challenge: AUD remains a significant public health issue affecting millions, and the passage of the new bill may provide Adial with clearer regulatory frameworks to address this substantial unmet treatment need.
- Impact of Policy Change: Adial's CEO Cary Claiborne noted that this legislation reflects a meaningful evolution in the evaluation and treatment of substance use disorders, which may foster innovation and improve clinical outcomes for patients.
See More
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- Earnings Beat: Super Micro Computer reported Q2 earnings of $0.69 per share, surpassing the analyst consensus of $0.49 by 41.68%, indicating a significant improvement in profitability that boosts investor confidence.
- Significant Revenue Growth: The quarterly revenue reached $12.68 billion, exceeding the market estimate of $10.22 billion and representing a 123.76% increase from $5.68 billion in the same period last year, showcasing the company's strong market performance and growth potential.
- Optimistic Outlook: Super Micro expects Q3 adjusted EPS of $0.60, above the analyst estimate of $0.53, and anticipates revenue in the range of $12.3 billion to $12.6 billion, reflecting confidence in future performance.
- Positive Stock Reaction: In pre-market trading, Super Micro's shares jumped 10.5% to $32.79, indicating a favorable market response to its strong earnings and optimistic outlook.
See More
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- Reverse Stock Split: Adial Pharmaceuticals announced a 1-for-25 reverse stock split effective Thursday, reducing outstanding shares from 27.8 million to approximately 1.1 million, aimed at regaining compliance with Nasdaq's minimum bid price requirement, although this led to a more than 20% drop in after-hours trading.
- AD04 Development Progress: The reverse split coincides with Adial's advancement of AD04, a genetically targeted treatment for Alcohol Use Disorder, with Phase 3 trial design completed, focusing on heavy drinkers and specific genotypes, indicating positive clinical progress for the company.
- FDA Regulatory Discussions: Adial has completed End-of-Phase-2 discussions with the FDA, receiving input on the Phase 3 adaptive trial design and broader clinical program, covering key elements such as patient population and endpoints, ensuring focus on biomarker-positive and negative groups.
- Strengthened Intellectual Property: The company has enhanced intellectual property protection for AD04, with an international patent application published, expected to safeguard core assets until at least 2045, reflecting a long-term strategic vision for market positioning.
See More
