5 Small-Cap ETFs Scaling New Highs
Small-Cap Stocks Performance: Small-cap stocks have surged, with the Russell 2000 Index gaining 10.4% this month amid expectations of Fed rate cuts, while the U.S. economy shows resilience with a GDP growth of 2.8% in Q2, driven by consumer spending and business investment.
Sector Opportunities and Risks: Lower interest rates are expected to benefit sectors like real estate, consumer discretionary, and financial services, while small-cap stocks are viewed as safer investments during political or economic turmoil, particularly amidst ongoing global conflicts.
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Small-Cap Stocks Performance: Small-cap stocks have surged, with the Russell 2000 Index gaining 10.4% this month amid expectations of Fed rate cuts, while the U.S. economy shows resilience with a GDP growth of 2.8% in Q2, driven by consumer spending and business investment.
Sector Opportunities and Risks: Lower interest rates are expected to benefit sectors like real estate, consumer discretionary, and financial services, while small-cap stocks are viewed as safer investments during political or economic turmoil, particularly amidst ongoing global conflicts.

- Coya Therapeutics Overview:
- A clinical-stage biotechnology company focusing on Tregs for inflammation and neuroinflammation treatments.
- Shares surged by 70% post-IPO, outperforming the Invesco S&P SmallCap Health Care ETF.
- Q&A with Howard Berman:
- Emphasizes a comprehensive approach over the traditional 'one disease – one target – one drug' model for neurodegenerative disorders.
- Moving towards combination approaches and biologics in line with the general biotech market trends.
- COYA 302 Program:
- Lead investigational biologic product targeting ALS, FTD, Parkinson’s, and Alzheimer’s diseases.
- Combines low-dose interleukin-2 and CTLA4-Ig for a dual mechanism of action to restore Treg function and suppress pro-inflammatory cells.
- Market and Competition:
- Targeting >50% of ALS patients initially, with plans for expansion into FTD.
- Differentiates from Biogen's product by aiming to treat all ALS patients and offering a different administration method.
- Future Outlook:
- Sees COYA 302 as a versatile treatment option for various neurodegenerative conditions driven by immune imbalance and Treg dysfunction.
- Plans for additional clinical trials in Alzheimer’s, Parkinson’s, and FTD in the future.
- PSCH ETF Overview: Invesco S&P SmallCap Health Care ETF (PSCH) is a passively managed fund launched in 2010, offering exposure to the Healthcare - Broad segment.
- Benefits of ETFs: Retail and institutional investors favor ETFs for low costs, transparency, flexibility, and tax efficiency, making them suitable for long-term investment.
- Index Details: PSCH seeks to match the performance of the S&P SmallCap 600 Capped Health Care Index, measuring common stock performance in the health care sector.
- Costs and Holdings: The ETF has an expense ratio of 0.29%, with a 100% allocation to the Healthcare sector and top holdings including ENSG, OGN, and ALKS.
- Performance and Alternatives: PSCH has returned 0.65% YTD, down -0.66% in the last year, with a high-risk profile. Investors can consider alternatives like VHT and XLV in the Health Care ETF space.
- Organon & Co Financial Performance: Reported a 5% Y/Y increase in Q1 2024 revenue to $1.622 billion, beating consensus.
- Revenue Breakdown: Women’s Health revenue increased by 11%, Biosimilar revenue surged by 46%, and Established Brands remained flat Y/Y.
- Margins and Earnings: Adjusted gross margin was 62.1%, adjusted EBITDA margin contracted to 33.2%, and adjusted EPS was $1.22.
- Financial Position: Cash and cash equivalents were $575 million, debt stood at $8.7 billion, and a quarterly dividend of $0.28 per share was declared.
- Guidance and Stock Performance: FY24 revenue forecast of $6.2-$6.5 billion, reaffirmed adjusted EBITDA margin, and OGN shares were up 2.18% at $19.24.








