Verastem Oncology Shares New Findings from GenFleet Therapeutics' Phase 1/2 Study of GFH375 (VS-7375) for Advanced KRAS G12D Mutant Pancreatic Ductal Adenocarcinoma in China
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 19 2025
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Should l Buy VSTM?
Source: Yahoo Finance
Efficacy of GFH375: GFH375, an oral KRAS G12D inhibitor, demonstrated a 41% overall response rate (ORR) in heavily pre-treated patients with advanced pancreatic ductal adenocarcinoma (PDAC) at a daily dose of 600 mg, with a disease control rate of 96.7% and a four-month overall survival rate of 92.2%.
Safety Profile: The treatment exhibited a manageable safety profile, with a low discontinuation rate of 4% due to adverse events, and the most common treatment-related adverse events included diarrhea and decreased neutrophil counts, with no treatment-related deaths reported.
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Analyst Views on VSTM
Wall Street analysts forecast VSTM stock price to rise
6 Analyst Rating
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 5.840
Low
14.00
Averages
15.60
High
20.00
Current: 5.840
Low
14.00
Averages
15.60
High
20.00
About VSTM
Verastem, Inc. is a late-stage development biopharmaceutical company, which focuses on the development and commercialization of new medicines to improve the lives of patients diagnosed with ras sarcoma (RAS)/ mitogen-activated pathway kinase (MAPK) pathway-driven cancers. Its product candidates include avutometinib and defactinib. Avutometinib is an oral RAF/MEK clamp that inhibits MEK1/2 kinase activities and induces inactive complexes of MEK with A-Raf proto-oncogene, potentially serine/threonine kinase (ARAF), B-Raf proto-oncogene serine/threonine kinase (BRAF) and C-raf proto-oncogene serine/threonine kinase, creating antitumor response through maximal RAS/MAPK pathway inhibition. Defactinib is an oral, selective inhibitor of FAK and proline-rich tyrosine kinase (PYK2), the two members of the focal adhesion kinase family of non-receptor protein tyrosine kinases. FAK and PYK2 integrate signals from integrin and growth factor receptors to regulate cell proliferation.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Accelerated Clinical Development: The company plans to rapidly advance its clinical development of VS-7375, a selective oral KRAS G12D inhibitor, which is expected to demonstrate best-in-class potential across multiple solid tumor indications, further solidifying its competitive edge in oncology.
- Future Strategic Focus: In 2026, Verastem will concentrate on maximizing the commercial launch of AVMAPKI FAKZYNJA CO-PACK while advancing its differentiated pipeline targeting RAS/MAPK pathway-driven cancers, aiming for sustainable long-term growth and self-sustaining commercialization by the second half of 2026.
See More
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- Clinical Trial Progress: Oncolytics Biotech's pelareorep achieved a 33% response rate in colorectal cancer patients, significantly surpassing the 6-11% typical response rates of conventional chemotherapy, which not only enhances treatment efficacy but also has the potential to redefine treatment standards in this field, bolstering the company's competitive edge.
- Management Team Upgrade: The recent appointments of John McAdory as Executive Vice President of Strategy and Operations and Yujun Wu as Vice President, Head of Biostatistics, both with extensive clinical trial experience, will provide critical support for Oncolytics' execution of complex multi-country registration trials, ensuring rapid and compliant advancement.
- FDA Trial Design Approval: Oncolytics has secured FDA approval for its Phase 3 trial design for pancreatic cancer, marking the imminent launch of the only immunotherapy registration trial planned for this notoriously difficult-to-treat disease, further solidifying its leadership position in oncology innovation.
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- Clinical Trial Progress: Oncolytics Biotech's pelareorep achieved a 33% response rate in colorectal cancer patients, significantly surpassing the 6-11% response rates typical of standard chemotherapy, indicating a potential shift in treatment paradigms.
- Management Team Upgrade: The company appointed two key executives, John McAdory and Yujun Wu, with extensive experience in complex late-stage clinical trials and biostatistics, respectively, which will provide robust support for Oncolytics' clinical trial execution.
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