NIH Discontinues Low-Dose Rivaroxaban Trial Amid Safety Concerns
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 3 days ago
0mins
Source: Benzinga
- Trial Discontinuation Reason: The NIH has halted the low-dose rivaroxaban arm of the CAPTIVA stroke prevention trial due to an independent safety review that identified increased safety events, indicating that the treatment is unlikely to provide benefits for the 1,683 enrolled participants.
- Safety Evaluation: This decision follows recommendations from the Data Safety and Monitoring Board, which oversees participant safety, highlighting NIH's commitment to participant welfare and a cautious approach towards new therapies.
- Trial Design Context: The CAPTIVA trial aims to assess whether rivaroxaban or ticagrelor is superior to clopidogrel in reducing the rates of ischemic stroke, intracerebral hemorrhage, or vascular death, involving over 100 sites and spanning four years.
- Market Reaction: Despite the trial's discontinuation, Johnson & Johnson's stock rose by 1.09% to $240.95 at the time of publication, reflecting market confidence in the company's other business segments, although this event may negatively impact the outlook for related products.
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Analyst Views on AZN
Wall Street analysts forecast AZN stock price to fall
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 204.520
Low
95.00
Averages
102.75
High
108.00
Current: 204.520
Low
95.00
Averages
102.75
High
108.00
About AZN
AstraZeneca PLC is a United Kingdom-based science-led biopharmaceutical company. The Company focuses on the discovery, development, and commercialization of prescription medicines. The Company operates across therapy areas, including Oncology; Cardiovascular, Renal and Metabolism (CVRM); Respiratory and Immunology (R&I); Vaccines and Immune Therapies (V&I), and Rare Disease. In the Oncology area, its key products include Tagrisso, Imfinzi, Calquence, Lynparza, and Enhertu. The key products of CVRM area include Farxiga/Forxiga, Brilinta/Brilique, Crestor, and Lokelma. In the R&I area, the key products are Symbicort, Fasenra, Breztri/Trixeo, and Tezspire. In the V&I Therapies area, the products are Beyfortus and FluMist. The products in the Rare Disease area are Ultomiris, Soliris, Strensiq, and Koselugo. It has about 191 projects in its development pipeline, including 19 new molecular entities (NMEs) in the late-stage pipeline. The Company distributes its products in over 125 countries.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Safety Evaluation: This decision follows recommendations from the Data Safety and Monitoring Board, which oversees participant safety, highlighting NIH's commitment to participant welfare and a cautious approach towards new therapies.
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AstraZeneca's Strong Performance: AstraZeneca reported a strong quarterly performance, with significant sales growth driven by its cancer medicines, which accounted for a large portion of its revenue, prompting positive investor sentiment.
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- Trial Discontinuation Reason: The NIH has halted the low-dose rivaroxaban arm of the CAPTIVA stroke prevention trial due to an independent safety review that identified increased safety events, indicating that the treatment is unlikely to provide benefits for the 1,683 enrolled participants.
- Safety Evaluation: This decision follows recommendations from the Data Safety and Monitoring Board, which oversees participant safety, highlighting NIH's commitment to participant welfare and a cautious approach towards new therapies.
- Trial Design Context: The CAPTIVA trial aims to assess whether rivaroxaban or ticagrelor is superior to clopidogrel in reducing the rates of ischemic stroke, intracerebral hemorrhage, or vascular death, involving over 100 sites and spanning four years.
- Market Reaction: Despite the trial's discontinuation, Johnson & Johnson's stock rose by 1.09% to $240.95 at the time of publication, reflecting market confidence in the company's other business segments, although this event may negatively impact the outlook for related products.
See More
