Intellia Therapeutics Reports $413M Cash Burn, Facing Funding Pressure
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 03 2026
0mins
Should l Buy NTLA?
Source: Yahoo Finance
- Cash Burn Analysis: Intellia Therapeutics reported a cash burn of $413 million over the past year, which constitutes about 40% of its $1 billion market capitalization, indicating significant dilution risk for shareholders if the company seeks additional funding.
- Cash Reserves Status: As of September 2025, Intellia had cash reserves of $511 million and zero debt, suggesting a cash runway of approximately 15 months at the current burn rate, reflecting short-term financial stability.
- Revenue Growth Potential: Despite a 14% year-over-year increase in cash burn, the company achieved a 34% rise in revenue, indicating business expansion and a promising outlook for reaching breakeven, with analysts forecasting profitability in about three years.
- Funding Capability Consideration: While the company shows positive growth, the ratio of cash burn to market cap raises concerns; if it needs to raise funds through share issuance, existing shareholders could face adverse effects from dilution.
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Analyst Views on NTLA
Wall Street analysts forecast NTLA stock price to rise
22 Analyst Rating
9 Buy
12 Hold
1 Sell
Moderate Buy
Current: 11.620
Low
4.00
Averages
16.50
High
54.00
Current: 11.620
Low
4.00
Averages
16.50
High
54.00
About NTLA
Intellia Therapeutics, Inc. is a clinical-stage gene editing company focused on developing medicine with CRISPR-based therapies. CRISPR is a gene editing technology which is also sometimes referred to as CRISPR/Cas or CRISPR/Cas9 when referring to the use of CRISPR technology with the Cas9 enzyme. Its in vivo product candidates address genetic diseases by deploying its technologies, including CRISPR/Cas9 delivered by LNPs, as the therapy for diseases with high unmet need. Its lead in vivo product candidates, nexiguran ziclumeran (nex-z or NTLA-2001) for the treatment of transthyretin (ATTR) amyloidosis and NTLA-2002 for the treatment of hereditary angioedema (HAE), are the first CRISPR-based therapy candidates to be administered systemically, via intravenous (IV) infusion, for precision editing of a gene in a target tissue in humans. For its ex vivo product candidates, it applies its technologies to create engineered cell therapies to address immuno-oncology and autoimmune diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Intellia Therapeutics Regulatory Progress and Market Potential
- Regulatory Progress: Intellia Therapeutics' stock has risen 41% following the FDA's lifting of the clinical hold on nex-z, indicating market confidence in its potential treatment, although another study remains on hold, necessitating caution from investors.
- Market Opportunity: Intellia estimates that the HAE market will reach $6.3 billion by 2030, while the transthyretin amyloidosis market could hit $16.8 billion, highlighting significant market potential in rare diseases despite facing clinical and regulatory hurdles.
- Investment Risks: Even with the potential launch of nex-z and lonvo-z, the complexity and high costs associated with gene editing medicines may limit their market performance, prompting investors to weigh these risks, particularly in clinical-stage biotech investments.
- Industry Competition: Intellia's exclusion from The Motley Fool Stock Advisor's list of the top 10 stocks reflects a cautious market outlook on its future performance, suggesting that investors should consider more promising investment opportunities.
See More
Analysis of Intellia Therapeutics' Stock Recovery
- Stock Recovery Reasons: Intellia Therapeutics' stock surged 10.73% following the FDA's lifting of the clinical hold on nex-z, indicating a restoration of market confidence after regulatory setbacks, which is expected to enhance its future investment appeal.
- Significant Market Potential: Nex-z targets transthyretin amyloidosis, affecting 50,000 patients globally, while the HAE market is projected to reach $6.3 billion by 2030, showcasing Intellia's vast market opportunities in rare disease treatments.
- Ongoing Clinical Risks: Despite the lifting of the clinical hold on nex-z, Intellia still faces regulatory challenges with other studies, particularly with lonvo-z, which could impact stock price stability and investor confidence.
- Investment Risk Advisory: Given the complexity and high costs associated with gene editing medicines, Intellia's stock remains a high-risk investment, suggesting that investors with lower risk tolerance should approach with caution.
See More
FDA Lifts Clinical Hold on Intellia's IND for ATTRv-PN Trial
- Clinical Hold Lifted: The FDA lifted the clinical hold on Intellia Therapeutics' MAGNITUDE-2 Phase 3 trial, allowing the company to proceed with its investigational new drug application for hereditary transthyretin amyloidosis (ATTRv-PN), which is expected to positively impact future R&D progress.
- Increased Enrollment Target: Intellia has raised the target enrollment for the MAGNITUDE-2 trial from approximately 50 to 60 patients, aiming to enhance the reliability of study results and bolster market confidence in its treatment approach.
- Positive Efficacy Data: In the ongoing Phase 1 study, patients receiving a one-time dose of 0.3 mg/kg or higher (n=33) showed a 92% mean reduction in serum TTR levels at 24 months, indicating the long-term efficacy of nexiguran ziclumeran, which may boost investor confidence in Intellia.
- Enhanced Safety Monitoring: Intellia has agreed with the FDA to implement enhanced safety monitoring measures for liver laboratory tests in the MAGNITUDE-2 trial, addressing previous safety events and providing stronger safety assurances for future clinical trials.
See More
FDA Lifts Clinical Hold on Intellia's Phase 3 Trial
- Clinical Trial Advancement: The FDA has lifted the clinical hold on Intellia's Phase 3 trial for a rare nerve disease following safety updates, marking a significant breakthrough in the company's critical R&D phase and potentially accelerating the path to market.
- Heart Disease Program Review: While the FDA has removed the hold on the Phase 3 trial, the review of Intellia's heart disease program continues, which may impact the company's market entry timeline and strategic positioning in the cardiovascular sector.
- Safety Update Impact: Intellia's safety updates have been recognized by the FDA, indicating effective measures taken to ensure patient safety during trials, which not only boosts investor confidence but may also attract more partners to its R&D initiatives.
- Market Reaction Expectations: With the FDA's positive developments, Intellia's stock price is likely to experience a favorable impact, as investors are optimistic about its future commercial potential and market performance, especially in the competitive landscape of rare disease treatments.
See More
FDA Lifts Clinical Hold on Nex-Z Trial for ATTRv-PN
- Trial Resumption: The FDA lifted the clinical hold on Intellia Therapeutics' Nexiguran Ziclumeran (Nex-Z) MAGNITUDE-2 Phase 3 trial, allowing the company to resume patient enrollment, which is expected to accelerate treatment progress for the rare nerve-damaging disease ATTRv-PN.
- Increased Enrollment Target: Following a protocol update, Intellia raised the target enrollment for MAGNITUDE-2 to approximately 60 patients, aiming to enhance the statistical power of the study and expedite the validation of the treatment option.
- Positive Market Reaction: Shares of Intellia surged over 13% after the FDA lifted the clinical hold, reflecting strong investor confidence in the potential efficacy of Nex-Z and optimistic expectations for the company's future growth.
- Retail Sentiment Shift: Retail sentiment on Stocktwits shifted from 'bullish' to 'extremely bullish' following the news, accompanied by high message volumes, indicating strong investor enthusiasm for the therapy's market prospects, with expectations for the stock to surpass $20 by the end of the trading session.
See More
HCA Healthcare Surges After Strong Q4 Earnings and Upgraded FY25 Guidance
- Earnings Beat: HCA Healthcare reported an adjusted EPS of $8.01 for Q4, surpassing the analyst consensus of $7.43, indicating robust profitability and strong market demand.
- Stock Surge: Following the earnings report, HCA's shares jumped 9.5% to $517.00 on Tuesday, reflecting investor confidence in the company's future growth prospects.
- Upgraded Guidance: The company raised its FY25 guidance above estimates, signaling a positive outlook for business development that may attract more investor interest.
- Positive Market Reaction: HCA's favorable news boosted overall market confidence in the healthcare sector, potentially leading to further gains in related stocks.
See More
Intellia Therapeutics Regulatory Progress and Market Potential
- Regulatory Progress: Intellia Therapeutics' stock has risen 41% following the FDA's lifting of the clinical hold on nex-z, indicating market confidence in its potential treatment, although another study remains on hold, necessitating caution from investors.
- Market Opportunity: Intellia estimates that the HAE market will reach $6.3 billion by 2030, while the transthyretin amyloidosis market could hit $16.8 billion, highlighting significant market potential in rare diseases despite facing clinical and regulatory hurdles.
- Investment Risks: Even with the potential launch of nex-z and lonvo-z, the complexity and high costs associated with gene editing medicines may limit their market performance, prompting investors to weigh these risks, particularly in clinical-stage biotech investments.
- Industry Competition: Intellia's exclusion from The Motley Fool Stock Advisor's list of the top 10 stocks reflects a cautious market outlook on its future performance, suggesting that investors should consider more promising investment opportunities.
See More
Analysis of Intellia Therapeutics' Stock Recovery
- Stock Recovery Reasons: Intellia Therapeutics' stock surged 10.73% following the FDA's lifting of the clinical hold on nex-z, indicating a restoration of market confidence after regulatory setbacks, which is expected to enhance its future investment appeal.
- Significant Market Potential: Nex-z targets transthyretin amyloidosis, affecting 50,000 patients globally, while the HAE market is projected to reach $6.3 billion by 2030, showcasing Intellia's vast market opportunities in rare disease treatments.
- Ongoing Clinical Risks: Despite the lifting of the clinical hold on nex-z, Intellia still faces regulatory challenges with other studies, particularly with lonvo-z, which could impact stock price stability and investor confidence.
- Investment Risk Advisory: Given the complexity and high costs associated with gene editing medicines, Intellia's stock remains a high-risk investment, suggesting that investors with lower risk tolerance should approach with caution.
See More
FDA Lifts Clinical Hold on Intellia's IND for ATTRv-PN Trial
- Clinical Hold Lifted: The FDA lifted the clinical hold on Intellia Therapeutics' MAGNITUDE-2 Phase 3 trial, allowing the company to proceed with its investigational new drug application for hereditary transthyretin amyloidosis (ATTRv-PN), which is expected to positively impact future R&D progress.
- Increased Enrollment Target: Intellia has raised the target enrollment for the MAGNITUDE-2 trial from approximately 50 to 60 patients, aiming to enhance the reliability of study results and bolster market confidence in its treatment approach.
- Positive Efficacy Data: In the ongoing Phase 1 study, patients receiving a one-time dose of 0.3 mg/kg or higher (n=33) showed a 92% mean reduction in serum TTR levels at 24 months, indicating the long-term efficacy of nexiguran ziclumeran, which may boost investor confidence in Intellia.
- Enhanced Safety Monitoring: Intellia has agreed with the FDA to implement enhanced safety monitoring measures for liver laboratory tests in the MAGNITUDE-2 trial, addressing previous safety events and providing stronger safety assurances for future clinical trials.
See More
FDA Lifts Clinical Hold on Intellia's Phase 3 Trial
- Clinical Trial Advancement: The FDA has lifted the clinical hold on Intellia's Phase 3 trial for a rare nerve disease following safety updates, marking a significant breakthrough in the company's critical R&D phase and potentially accelerating the path to market.
- Heart Disease Program Review: While the FDA has removed the hold on the Phase 3 trial, the review of Intellia's heart disease program continues, which may impact the company's market entry timeline and strategic positioning in the cardiovascular sector.
- Safety Update Impact: Intellia's safety updates have been recognized by the FDA, indicating effective measures taken to ensure patient safety during trials, which not only boosts investor confidence but may also attract more partners to its R&D initiatives.
- Market Reaction Expectations: With the FDA's positive developments, Intellia's stock price is likely to experience a favorable impact, as investors are optimistic about its future commercial potential and market performance, especially in the competitive landscape of rare disease treatments.
See More
FDA Lifts Clinical Hold on Nex-Z Trial for ATTRv-PN
- Trial Resumption: The FDA lifted the clinical hold on Intellia Therapeutics' Nexiguran Ziclumeran (Nex-Z) MAGNITUDE-2 Phase 3 trial, allowing the company to resume patient enrollment, which is expected to accelerate treatment progress for the rare nerve-damaging disease ATTRv-PN.
- Increased Enrollment Target: Following a protocol update, Intellia raised the target enrollment for MAGNITUDE-2 to approximately 60 patients, aiming to enhance the statistical power of the study and expedite the validation of the treatment option.
- Positive Market Reaction: Shares of Intellia surged over 13% after the FDA lifted the clinical hold, reflecting strong investor confidence in the potential efficacy of Nex-Z and optimistic expectations for the company's future growth.
- Retail Sentiment Shift: Retail sentiment on Stocktwits shifted from 'bullish' to 'extremely bullish' following the news, accompanied by high message volumes, indicating strong investor enthusiasm for the therapy's market prospects, with expectations for the stock to surpass $20 by the end of the trading session.
See More
HCA Healthcare Surges After Strong Q4 Earnings and Upgraded FY25 Guidance
- Earnings Beat: HCA Healthcare reported an adjusted EPS of $8.01 for Q4, surpassing the analyst consensus of $7.43, indicating robust profitability and strong market demand.
- Stock Surge: Following the earnings report, HCA's shares jumped 9.5% to $517.00 on Tuesday, reflecting investor confidence in the company's future growth prospects.
- Upgraded Guidance: The company raised its FY25 guidance above estimates, signaling a positive outlook for business development that may attract more investor interest.
- Positive Market Reaction: HCA's favorable news boosted overall market confidence in the healthcare sector, potentially leading to further gains in related stocks.
See More
