ImmunityBio's QUILT-3.078 Study Shows 19 Patients Alive, Median Survival Not Yet Reached
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 23 2026
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Should l Buy IBRX?
Source: Newsfilter
- Survival Rate Highlights: As of January 22, 2026, 19 of 23 patients in the QUILT-3.078 study for recurrent glioblastoma remain alive, indicating the potential efficacy of this treatment in patients with severe lymphopenia, with median overall survival not yet reached, exceeding current standard treatment expectations.
- Significant Lymphocyte Recovery: Among 14 evaluable patients, the baseline absolute lymphocyte count (ALC) was 0.9 x 103/uL, which significantly increased to ≥1.4 x 103/uL (p <0.001) within one treatment cycle, suggesting maintained and improved immune competence that may provide better survival chances for patients.
- Good Safety Profile: A total of 219 doses have been administered in the QUILT-3.078 study, with three treatment-related serious adverse events reported, and no cases of cytokine release syndrome (CRS) or immune effector cell-associated neurotoxicity syndrome (ICANS) observed, demonstrating the manageable safety of this treatment regimen.
- Clinical Trial Prospects: ImmunityBio is developing randomized controlled trials for recurrent glioblastoma to further evaluate the efficacy and tolerability of this immunotherapy regimen, highlighting the innovative potential in this high-need area.
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Analyst Views on IBRX
Wall Street analysts forecast IBRX stock price to rise
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 6.620
Low
5.00
Averages
7.33
High
9.00
Current: 6.620
Low
5.00
Averages
7.33
High
9.00
About IBRX
Immunitybio, Inc. is a vertically integrated, clinical-stage biotechnology company developing therapies and vaccines that bolster the natural immune system to defeat cancers and infectious diseases. Using its applied science and platforms to treat cancers, including the development of potential cancer vaccines, as well as developing immunotherapies and cell therapies to reduce or eliminate the need for standard high-dose chemotherapy. Its platforms and their associated product candidates are designed to attack cancer and infectious pathogens by activating both the innate immune system, including NK cells, dendritic cells, and macrophages, as well as the adaptive immune system comprising B and T cells, in an orchestrated manner. Its platforms for the development of biologic product candidates include antibody-cytokine fusion proteins, vaccine vectors, and cell therapies. Its biologic commercial product candidate, Anktiva, is an IL-15 superagonist antibody-cytokine fusion protein.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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See More
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- Attraction of Shorted Stocks: LCID stock has become a target for heavy shorting as many experienced traders and institutional investors believe the company's fundamentals are overvalued, reflecting a pessimistic outlook on its future performance.
- Short Selling Mechanics: Short sellers bet on significant risks facing the company, such as poor earnings or industry headwinds, which may lead to a decline in stock price, thus garnering attention for short-selling strategies in the market.
- Short Squeeze Dynamics: When a stock's price unexpectedly rises, short sellers are forced to buy back shares to cover their positions, creating a surge in demand that further drives up the price, resulting in a feedback loop that can lead to explosive gains in a short time frame.
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- Clinical Trial Results Underwhelming: On January 23, 2026, ImmunityBio announced that the primary endpoint of its immunotherapy trial for recurrent glioblastoma, the median overall survival, has not yet been reached, potentially impacting its future market performance.
- Significant Stock Price Drop: Following the release of unfavorable news, ImmunityBio's stock price fell by $0.89, a decline of 12.13%, closing at $6.45 per share, reflecting market disappointment regarding its clinical results.
- Law Firm Background: Pomerantz LLP is a prominent law firm specializing in securities and antitrust class litigation, with over 85 years of history advocating for the rights of victims of securities fraud, potentially providing legal support for affected investors.
See More
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- Positive Market Reaction: On Stocktwits, retail sentiment around IBRX shares remains in the 'bullish' territory with high message volume, and IBRX stock has gained approximately 90% over the past 12 months, reflecting investor confidence in the company's future developments.
See More
Market Analysis of Heavily Shorted Stocks
- Attraction of Shorted Stocks: Investors maintain high short interest in overvalued stocks, indicating significant perceived risks such as poor earnings or industry headwinds that could drive prices down, impacting market sentiment and investment strategies.
- Bear vs. Bull Dynamics: Short sellers meticulously identify companies they view as ticking time bombs, while retail traders see high short interest as a potential springboard for price rebounds, where rising stock prices can trigger short squeezes, affecting market liquidity.
- Understanding Short Squeeze Mechanics: A short squeeze creates a volatile feedback loop initiated by unexpected price increases, forcing short sellers to buy back shares to cover positions, which spikes demand and further elevates prices, trapping more short sellers and potentially leading to outsized returns.
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See More
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- Positive Clinical Results: In the Phase 1 study, all four patients with Waldenström’s Macroglobulinemia achieved clinical disease control when treated with CD19 CAR-NK cells combined with rituximab, with two patients maintaining complete remission at 7 and 15 months follow-up, indicating the therapy's potential.
- Significant Therapy Advantages: The design of the ResQ215B study eliminates the need for lymphodepleting chemotherapy, offering a safer treatment option that could transform the current treatment paradigm for indolent B-cell malignancies, particularly for patients deemed incurable.
- Enhanced Immune Response: By incorporating ANKTIVA, the study aims to further stimulate NK and CD8 T-cell activity, enhancing anti-tumor efficacy and potentially overcoming tumor resistance to rituximab, thereby improving the depth and durability of treatment responses.
See More
