Guggenheim Begins Coverage of Context Therapeutics (CNTX) with a Buy Rating
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Sep 19 2025
0mins
Should l Buy CNTX?
Source: NASDAQ.COM
Guggenheim Coverage Initiation: On September 18, 2025, Guggenheim initiated coverage of Context Therapeutics (NasdaqCM:CNTX) with a "Buy" recommendation, projecting a 433.07% upside based on an average one-year price target of $5.30/share.
Institutional Ownership Trends: There are currently 52 funds reporting positions in Context Therapeutics, reflecting a decrease of 8.77% in ownership over the last quarter, while the average portfolio weight dedicated to CNTX has increased by 11.50%.
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Analyst Views on CNTX
Wall Street analysts forecast CNTX stock price to rise
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 2.430
Low
4.00
Averages
5.25
High
7.00
Current: 2.430
Low
4.00
Averages
5.25
High
7.00
About CNTX
Context Therapeutics Inc. is a clinical-stage biopharmaceutical company, which is engaged in advancing T cell engaging (TCE) bispecific antibodies (bsAb) for solid tumors. It is building a portfolio of TCE bispecific therapeutics, including CTIM-76, a Claudin 6 (CLDN6) x CD3 TCE, CT-95, a Mesothelin (MSLN) x CD3 TCE, and CT-202, a Nectin cell adhesion protein 4 (Nectin-4) x CD3 TCE. CLDN6 is a tight junction membrane protein target expressed in multiple solid tumors and absent from or expressed at low levels in healthy adult tissues. CT-95 is intended to redirect T-cell-mediated lysis toward malignant cells expressing MSLN. MSLN is a membrane protein overexpressed in approximately 30% of cancers. Nectin-4 is a target for cancer therapy using a traditional antibody-drug conjugate, but it is also associated with certain adverse events, including neuropathy and rash. CT-202 is a pH-dependent TCE that is designed to be preferentially active within the acidic tumor microenvironment.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Context Therapeutics Announces Upcoming Investor Conference Schedule
- Investor Conference Schedule: Context Therapeutics will participate in the Guggenheim Emerging Outlook: Biotech Summit on February 11-12, 2026, in New York, featuring 1x1 meetings aimed at enhancing the company's visibility among investors.
- Multiple Conference Participation: The company will also attend the TD Cowen 46th Annual Health Care Conference from March 2-4, 2026, in Boston, with a presentation scheduled for March 3, showcasing its innovations in the biopharmaceutical sector.
- Live Webcast and Replays: All presentations will be live-streamed on the company's website, with replays available for 90 days post-event, ensuring that investors unable to attend in person can access critical information, thereby enhancing transparency.
- Product Development Outlook: Context Therapeutics focuses on developing T cell engaging bispecific antibodies for solid tumors, and the upcoming conferences will provide a platform to showcase its candidates CTIM-76, CT-95, and CT-202, potentially attracting increased investor interest.
See More
Context Therapeutics Grants 120,000 Stock Options to Attract New Employees
- Employee Incentive Program: Context Therapeutics has granted a total of 120,000 non-qualified stock options to two new employees as an inducement for accepting employment, demonstrating the company's proactive strategy in talent acquisition.
- Option Grant Details: The stock options were granted at exercise prices of $1.47 and $1.49 per share, based on the closing prices on the grant dates, reflecting the company's confidence in its stock value.
- Long-Term Incentive Mechanism: The stock options have a 10-year term and vest over four years, with 25% vesting on the first anniversary and the remainder vesting in monthly installments, aimed at enhancing employee commitment and stability.
- Company Strategic Direction: Context Therapeutics focuses on developing T cell engaging bispecific antibodies for solid tumors, aiming to accelerate its innovative drug development process by attracting top talent, thereby enhancing its market competitiveness.
See More
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- Broad Market Outlook: The total addressable market for pelareorep in colorectal cancer is projected to reach $20 billion by 2033, highlighting the drug's significance in addressing unmet medical needs.
- Strategic Planning: The company plans to initiate a controlled study in second-line KRAS-mutant colorectal cancer following consultations with key opinion leaders and regulatory authorities, enhancing the analytical rigor of data to support potential regulatory submissions.
- Expert Endorsement: Dr. Sanjay Goel from Rutgers Cancer Institute emphasizes that a 33% response rate is highly unusual in this setting, underscoring the necessity for further studies and indicating the clinical value of the drug.
See More
Context Therapeutics Announces Upcoming Investor Conference Schedule
- Investor Conference Schedule: Context Therapeutics will participate in the Guggenheim Emerging Outlook: Biotech Summit on February 11-12, 2026, in New York, featuring 1x1 meetings aimed at enhancing the company's visibility among investors.
- Multiple Conference Participation: The company will also attend the TD Cowen 46th Annual Health Care Conference from March 2-4, 2026, in Boston, with a presentation scheduled for March 3, showcasing its innovations in the biopharmaceutical sector.
- Live Webcast and Replays: All presentations will be live-streamed on the company's website, with replays available for 90 days post-event, ensuring that investors unable to attend in person can access critical information, thereby enhancing transparency.
- Product Development Outlook: Context Therapeutics focuses on developing T cell engaging bispecific antibodies for solid tumors, and the upcoming conferences will provide a platform to showcase its candidates CTIM-76, CT-95, and CT-202, potentially attracting increased investor interest.
See More
Context Therapeutics Grants 120,000 Stock Options to Attract New Employees
- Employee Incentive Program: Context Therapeutics has granted a total of 120,000 non-qualified stock options to two new employees as an inducement for accepting employment, demonstrating the company's proactive strategy in talent acquisition.
- Option Grant Details: The stock options were granted at exercise prices of $1.47 and $1.49 per share, based on the closing prices on the grant dates, reflecting the company's confidence in its stock value.
- Long-Term Incentive Mechanism: The stock options have a 10-year term and vest over four years, with 25% vesting on the first anniversary and the remainder vesting in monthly installments, aimed at enhancing employee commitment and stability.
- Company Strategic Direction: Context Therapeutics focuses on developing T cell engaging bispecific antibodies for solid tumors, aiming to accelerate its innovative drug development process by attracting top talent, thereby enhancing its market competitiveness.
See More
Alumis Inc. (ALMS) Shares Surge 17.33% on Phase 3 Clinical Trial Data Announcement
- Alumis Clinical Progress: Alumis Inc. announced it will report topline data from its Phase 3 ONWARD clinical trial for moderate-to-severe plaque psoriasis on January 6, 2026, leading to a 17.33% stock surge, reflecting strong investor optimism ahead of the results.
- Genelux Trial Results: Genelux Corp. saw a 10.92% increase in share price following interim results from two ongoing trials, indicating that its Olvi-Vec may effectively resensitize tumors in small cell and non-small cell lung cancer patients, boosting market confidence in its product.
- Bright Minds Conference Announcement: Bright Minds Biosciences Inc. will host a conference call on January 6, 2026, to report results from its Phase 2 trial for drug-resistant absence seizures, with an 8.42% stock increase reflecting market anticipation for its findings.
- Alpha Tau FDA Submission: Alpha Tau Medical Ltd. submitted the first module of its pre-market approval application for Alpha DaRT to treat recurrent cutaneous squamous cell carcinoma, resulting in a 5.36% stock rise, as this modular approach may expedite the approval process and enhance market confidence.
See More
GH Research PLC Shares Surge 18.1% on FDA IND Status Update Announcement
- Significant Stock Surge: GH Research PLC shares rose 18.1% to $15.64 in pre-market trading, reflecting strong market anticipation for the upcoming update on its FDA IND status and Phase 3 program for GH001, which could pave the way for future drug approvals.
- Positive Market Reaction: As the company prepares to update its treatment plan for treatment-resistant depression, investor confidence in GH Research's prospects has significantly increased, potentially attracting more investors and enhancing the company's market valuation.
- Industry-Wide Impact: The progress of GH Research may not only boost its own stock price but also positively influence the entire biopharmaceutical sector, particularly in the treatment-resistant depression space, encouraging other companies to increase their R&D investments.
- Optimistic Future Outlook: With the FDA update on the horizon, GH Research is poised to gather more clinical data in the coming months, which will provide crucial support for its subsequent marketing and commercialization strategies, strengthening its position in the competitive pharmaceutical market.
See More
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- Invivyd Rating Upgrade: BTIG analyst Thomas Shrader initiated coverage on Invivyd Inc (NASDAQ:IVVD) with a Buy rating and a price target of $10, indicating a potential upside of 335% from its closing price of $2.30, reflecting strong market optimism about its future growth prospects.
- Positive Outlook for Relmada Therapeutics: Jefferies analyst Farzin Haque initiated coverage on Relmada Therapeutics Inc (NASDAQ:RLMD) with a Buy rating and a price target of $9, suggesting a 106% upside from its current price of $4.35, indicating confidence in its product pipeline.
- Context Therapeutics Seen Favorably: Jones Trading analyst Soumit Roy initiated coverage on Context Therapeutics Inc (NASDAQ:CNTX) with a Buy rating and a price target of $7, representing a potential gain of 450% from its current price of $1.27, reflecting positive sentiment regarding its R&D progress.
- Investment Opportunity in BlackSky Technology: Jefferies initiated coverage on BlackSky Technology Inc (NYSE:BKSY) with a Buy rating and a price target of $23, indicating a 19% upside from its closing price of $19.25, showcasing analyst confidence in its market performance.
See More
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- Clinical Trial Breakthrough: Oncolytics Biotech's pelareorep achieves a 33% objective response rate in KRAS-mutant metastatic colorectal cancer patients, significantly surpassing the historical benchmark of 6-11%, indicating its potential in cancer treatment.
- Broad Market Outlook: The total addressable market for pelareorep in colorectal cancer is projected to reach $20 billion by 2033, highlighting the drug's significance in addressing unmet medical needs.
- Strategic Planning: The company plans to initiate a controlled study in second-line KRAS-mutant colorectal cancer following consultations with key opinion leaders and regulatory authorities, enhancing the analytical rigor of data to support potential regulatory submissions.
- Expert Endorsement: Dr. Sanjay Goel from Rutgers Cancer Institute emphasizes that a 33% response rate is highly unusual in this setting, underscoring the necessity for further studies and indicating the clinical value of the drug.
See More
