EXCLUSIVE: Vivani Prioritizes Semaglutide-Based Implant After Promising Preclinical Data
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Aug 05 2025
0mins
Should l Buy VANI?
Source: Benzinga
LIBERATE-1 Study Results: Vivani Medical Inc. reported positive results from the LIBERATE-1 Phase 1 study of its exenatide GLP-1 implant, NPM-115, demonstrating safety and tolerability over a 9-week period without serious adverse events.
Semaglutide Implant Development: The company is prioritizing the development of its semaglutide implant, NPM-139, which has shown promising preclinical data for long-term weight loss, with plans to submit an Investigational New Drug application soon.
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Analyst Views on VANI
Wall Street analysts forecast VANI stock price to rise
2 Analyst Rating
2 Buy
0 Hold
0 Sell
Moderate Buy
Current: 1.170
Low
4.00
Averages
4.00
High
4.00
Current: 1.170
Low
4.00
Averages
4.00
High
4.00
About VANI
Vivani Medical, Inc. is a clinical-stage biopharmaceutical company, developing miniature, ultra-long-acting drug implants. Leveraging its NanoPortal platform, it develops biopharmaceutical implants designed to deliver drug molecules steadily over extended periods of time with the goal of guaranteeing adherence, and to improve patient tolerance to their medication. Its lead program, NPM-115, is a six-month, subdermal, GLP-1 (exenatide) implant under development for chronic weight management in overweight individuals. Its pipeline includes NPM-139 (semaglutide implant), which is also under development for chronic weight management. NPM-119 refers to its six-month, subdermal, GLP-1 (exenatide) implant under development for the treatment of type 2 diabetes. These NanoPortal implants are designed to provide patients with the opportunity to realize the benefit of their medication by avoiding the challenges associated with the daily or weekly administration of orals and injectables.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Cortigent's Brain Implant Device Receives FDA Approval
- Clinical Study Results: Cortigent presented the results of a 6-year Early Feasibility Study of the Orion Visual Cortical Prosthesis System at the North American Neuromodulation Society annual meeting, demonstrating good safety and reliability, with plans for a larger pivotal trial to seek FDA marketing approval.
- Device Performance: Among the six subjects implanted between 2018 and 2019, all showed significant improvement in visual function tests, with final Functional Low-vision Observer Rated Assessment (FLORA) scores being positive or mildly positive, indicating a beneficial impact of the Orion system on their quality of life.
- Electrode Stability: Throughout the study, all devices remained functional with a functionality loss rate of less than 4%, indicating the reliability of the Orion system for long-term use and laying a foundation for future market introduction.
- Strategic Development Plans: Cortigent CEO Jonathan Adams stated that the company will collaborate with the FDA and world-leading experts to advance the Orion system, aiming to provide meaningful visual perception for the blind, showcasing the company's strategic vision in neurostimulation technology.
See More
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- Offering Size: Vivani Medical has priced 1,689,200 common shares at $1.48 each, alongside a concurrent private placement of 1,351,351 shares purchased by Chairman Gregg Williams, raising a total of $4.5 million, indicating strong market interest in the company.
- Use of Proceeds: The net proceeds from this offering will fund ongoing research and clinical development of the company's product candidates, as well as provide working capital and general corporate purposes, ensuring sustained growth in a competitive healthcare landscape.
- Transaction Timeline: The registered offering and private placement are expected to close around January 27, providing the company with a swift influx of capital that will accelerate its research and development efforts.
- Market Reaction: The successful pricing of this offering reflects investor confidence in Vivani Medical's growth potential, which may positively impact the company's stock price and strengthen its market position in the healthcare sector.
See More
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- Stock Offering Plan: Vivani Medical plans to sell 1.69 million shares at $1.48 each, alongside a private placement of 1.35 million shares, expecting gross proceeds of approximately $4.5 million, indicating proactive financing efforts.
- Clinical Development Outlook: The company anticipates initiating clinical development of NPM-139 for obesity and chronic weight management in 2026, highlighting its commitment to innovation in the biopharmaceutical sector and responsiveness to market demands.
- Clear Use of Funds: The net proceeds from the stock offering will be allocated to fund ongoing research and clinical development of product candidates, as well as for working capital and general corporate purposes, ensuring sustainable growth for the company.
- Stock Performance Review: VANI has traded between $0.90 and $1.92 over the past year, closing at $1.48 with a decline of 0.68%, reflecting a cautious market sentiment towards the company's stock.
See More
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- Clinical Research Results: Following a six-year Early Feasibility Study, the Orion system utilizes a high-channel-count micro-electrode array to stimulate the visual cortex, converting video input from a wearable camera into phosphenes, demonstrating its potential in clinical applications for aiding navigation in blind individuals.
- Device Design: The Orion system features an implantable pulse generator with 60 outputs, roughly the size of three stacked dimes, connected to a 60-electrode cortical surface array, designed to support consistent visual perception and potentially serve as a practical assistive tool for common blindness causes like glaucoma and diabetic retinopathy.
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See More
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- Technological Breakthrough: Cortigent's Orion cortical stimulation system has successfully completed a six-year Early Feasibility Study aimed at treating common forms of blindness, marking a significant advancement in neurostimulation technology that could offer visual perception hope to millions of blind individuals.
- Microelectrode Innovation: The system features a 60-output microelectrode array capable of precise electrical stimulation control, which is expected to significantly enhance navigation abilities for blind users, thereby improving their quality of life and independence.
- Clinical Application Potential: The design of the Orion system is based on 17 years of safe and effective use of the Argus II device, indicating its potential for clinical application and possibly driving further growth for Cortigent in the medical device market.
- Industry Influence: Cortigent will present its technology at the North American Neuromodulation Society annual meeting, further solidifying its leadership position in electrical brain implant technologies and fostering innovation through interaction with leading global researchers.
See More
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Clinical Development Plans: Vivani Medical plans to initiate a Phase 1 clinical study of its semaglutide implant for chronic weight management in the first half of 2026, with parallel investments for a Phase 2 study pending regulatory feedback.
Financial Position: The company raised approximately $25.7 million through private placements and financings in 3Q 2025 to support the accelerated development of its NPM-139 implant, ensuring financial stability into 2027.
Recent Achievements: Vivani successfully completed the LIBERATE-1 clinical study, marking a significant milestone for its NanoPortal™ technology, which aims to improve medication adherence and tolerability for obesity treatment.
Spin-off Update: The planned spin-off of Vivani's subsidiary, Cortigent, has been temporarily withdrawn due to the U.S. federal government shutdown, with a new record date expected to be established once normal SEC operations resume.
See More
Cortigent's Brain Implant Device Receives FDA Approval
- Clinical Study Results: Cortigent presented the results of a 6-year Early Feasibility Study of the Orion Visual Cortical Prosthesis System at the North American Neuromodulation Society annual meeting, demonstrating good safety and reliability, with plans for a larger pivotal trial to seek FDA marketing approval.
- Device Performance: Among the six subjects implanted between 2018 and 2019, all showed significant improvement in visual function tests, with final Functional Low-vision Observer Rated Assessment (FLORA) scores being positive or mildly positive, indicating a beneficial impact of the Orion system on their quality of life.
- Electrode Stability: Throughout the study, all devices remained functional with a functionality loss rate of less than 4%, indicating the reliability of the Orion system for long-term use and laying a foundation for future market introduction.
- Strategic Development Plans: Cortigent CEO Jonathan Adams stated that the company will collaborate with the FDA and world-leading experts to advance the Orion system, aiming to provide meaningful visual perception for the blind, showcasing the company's strategic vision in neurostimulation technology.
See More
Vivani Medical Prices $4.5M Offering for Growth Initiatives
- Offering Size: Vivani Medical has priced 1,689,200 common shares at $1.48 each, alongside a concurrent private placement of 1,351,351 shares purchased by Chairman Gregg Williams, raising a total of $4.5 million, indicating strong market interest in the company.
- Use of Proceeds: The net proceeds from this offering will fund ongoing research and clinical development of the company's product candidates, as well as provide working capital and general corporate purposes, ensuring sustained growth in a competitive healthcare landscape.
- Transaction Timeline: The registered offering and private placement are expected to close around January 27, providing the company with a swift influx of capital that will accelerate its research and development efforts.
- Market Reaction: The successful pricing of this offering reflects investor confidence in Vivani Medical's growth potential, which may positively impact the company's stock price and strengthen its market position in the healthcare sector.
See More
Vivani Medical Launches Stock Offering to Raise $4.5 Million
- Stock Offering Plan: Vivani Medical plans to sell 1.69 million shares at $1.48 each, alongside a private placement of 1.35 million shares, expecting gross proceeds of approximately $4.5 million, indicating proactive financing efforts.
- Clinical Development Outlook: The company anticipates initiating clinical development of NPM-139 for obesity and chronic weight management in 2026, highlighting its commitment to innovation in the biopharmaceutical sector and responsiveness to market demands.
- Clear Use of Funds: The net proceeds from the stock offering will be allocated to fund ongoing research and clinical development of product candidates, as well as for working capital and general corporate purposes, ensuring sustainable growth for the company.
- Stock Performance Review: VANI has traded between $0.90 and $1.92 over the past year, closing at $1.48 with a decline of 0.68%, reflecting a cautious market sentiment towards the company's stock.
See More
Vivani Medical's Cortigent Unveils Orion Visual Prosthesis Insights at NANS 2026
- Technical Presentation: Vivani Medical's wholly owned subsidiary, Cortigent, will present new technical insights into its Orion Visual Cortical Prosthesis System at the North American Neuromodulation Society annual meeting on January 23, 2026, aimed at delivering meaningful visual perception to individuals who are completely blind.
- Clinical Research Results: Following a six-year Early Feasibility Study, the Orion system utilizes a high-channel-count micro-electrode array to stimulate the visual cortex, converting video input from a wearable camera into phosphenes, demonstrating its potential in clinical applications for aiding navigation in blind individuals.
- Device Design: The Orion system features an implantable pulse generator with 60 outputs, roughly the size of three stacked dimes, connected to a 60-electrode cortical surface array, designed to support consistent visual perception and potentially serve as a practical assistive tool for common blindness causes like glaucoma and diabetic retinopathy.
- Market Potential: Cortigent is also developing a separate neurostimulation device aimed at improving arm and hand motor recovery in stroke patients, showcasing the broad application potential of its precision neurostimulation platform and further solidifying Vivani's market position in the biopharmaceutical sector.
See More
Cortigent's Orion Visual Stimulation System Completes 6-Year Feasibility Study
- Technological Breakthrough: Cortigent's Orion cortical stimulation system has successfully completed a six-year Early Feasibility Study aimed at treating common forms of blindness, marking a significant advancement in neurostimulation technology that could offer visual perception hope to millions of blind individuals.
- Microelectrode Innovation: The system features a 60-output microelectrode array capable of precise electrical stimulation control, which is expected to significantly enhance navigation abilities for blind users, thereby improving their quality of life and independence.
- Clinical Application Potential: The design of the Orion system is based on 17 years of safe and effective use of the Argus II device, indicating its potential for clinical application and possibly driving further growth for Cortigent in the medical device market.
- Industry Influence: Cortigent will present its technology at the North American Neuromodulation Society annual meeting, further solidifying its leadership position in electrical brain implant technologies and fostering innovation through interaction with leading global researchers.
See More
Vivani Medical Shares Business Update and Announces Financial Results for Third Quarter 2025
Clinical Development Plans: Vivani Medical plans to initiate a Phase 1 clinical study of its semaglutide implant for chronic weight management in the first half of 2026, with parallel investments for a Phase 2 study pending regulatory feedback.
Financial Position: The company raised approximately $25.7 million through private placements and financings in 3Q 2025 to support the accelerated development of its NPM-139 implant, ensuring financial stability into 2027.
Recent Achievements: Vivani successfully completed the LIBERATE-1 clinical study, marking a significant milestone for its NanoPortal™ technology, which aims to improve medication adherence and tolerability for obesity treatment.
Spin-off Update: The planned spin-off of Vivani's subsidiary, Cortigent, has been temporarily withdrawn due to the U.S. federal government shutdown, with a new record date expected to be established once normal SEC operations resume.
See More
