ASH 2025: Ascentage Pharma Shares Promising Results from Phase Ib/II Trial of Bcl-2 Inhibitor Lisaftoclax in Patients with Myeloid Malignancies Previously Treated with Venetoclax
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 08 2025
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Should l Buy AAPG?
Source: Yahoo Finance
Clinical Study Results: Preliminary evidence from a Phase Ib/II study shows that Lisaftoclax, in combination with azacitidine, achieves a 31.8% overall response rate in patients with venetoclax-resistant myeloid malignancies, and an 80% response rate in newly diagnosed high-risk MDS/CMML patients.
Safety Profile: The study, which included 103 patients, reported a strong safety profile for Lisaftoclax with no dose-limiting toxicities, although common grade ≥3 treatment-emergent adverse events included neutropenia and thrombocytopenia.
Therapeutic Potential: Lisaftoclax is a novel Bcl-2 selective inhibitor that shows promise in overcoming resistance to venetoclax, potentially offering new treatment options for patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
Company Background: Ascentage Pharma, the developer of Lisaftoclax, is focused on innovative cancer therapies and is conducting multiple global registrational Phase III studies for various hematologic malignancies, with a commitment to addressing unmet medical needs.
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Analyst Views on AAPG
Wall Street analysts forecast AAPG stock price to rise
6 Analyst Rating
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 23.200
Low
45.00
Averages
48.67
High
51.00
Current: 23.200
Low
45.00
Averages
48.67
High
51.00
About AAPG
Ascentage Pharma Group International is an investment holding company primarily engaged in the discovery, development, and commercialization of therapies for hematologic malignancies. The Company's main products include Olverembatinib (HQP1351), Lisaftoclax (APG-2575), Alrizomadlin (APG-115), Pelcitoclax (APG-1252), APG-5918, and APG-2449. The Company's products are primarily used to treat chronic myeloid leukemia (CML), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), myelodysplastic syndrome (MDS) and multiple myeloma (MM). The Company primarily conducts its businesses in domestic market.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Urgent Clinical Need: Given BTK's critical role in the B-cell signaling pathway, the development of APG-3288 is particularly significant for patients resistant to BTK inhibitors, addressing the urgent clinical need for new drugs with novel mechanisms of action and potentially offering new treatment options.
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