Adlai Nortye Enters Exclusive Licensing Agreement with ASK Pharm for AN9025 Worth Up to $230 Million
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 29 2025
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Should l Buy ANL?
Source: Newsfilter
- Strategic Partnership: Adlai Nortye has signed an exclusive licensing agreement with ASK Pharm, granting ASK rights to develop and commercialize AN9025 in mainland China, Hong Kong, and Macao, with potential total revenues of up to RMB 1.6 billion (approximately $230 million), highlighting the company's strong potential in the Chinese market.
- Upfront and Milestone Payments: The agreement includes over $20 million in upfront payments and near-term milestone payments, ensuring Adlai Nortye receives funding support in the early stages of the project, thereby accelerating the development of AN9025.
- Market Potential: AN9025, an oral small molecule pan-RAS inhibitor targeting RAS mutations across various tumor types, is expected to initiate its Phase I clinical trial in Q1 2026, potentially offering innovative treatment options in the Chinese market to meet significant unmet medical needs.
- R&D Synergy: This collaboration combines Adlai Nortye's innovation capabilities with ASK Pharm's expertise in development and commercialization in Greater China, aiming to accelerate the clinical and commercial potential of AN9025 and strengthen the company's leadership position in cancer treatment.
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About ANL
Adlai Nortye Ltd. is a Cayman Islands-based investment holding company. The Company is involved in the research and development of pharmaceutical products. It is a clinical-stage company focused on the development of targeted and immune-modulating cancer therapies. It is advancing an oncology pipeline, with Buparlisib (AN2025), a pan-phosphoinositide 3-kinase (PI3K) inhibitor, being evaluated in a registrational Phase three trial (NCT04338399) for patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC) that has progressed after prior anti-programmed death-ligand 1 (PD-L1) treatment. It is also advancing multiple drug candidates, including AN4005, an oral small molecule PD-L1 inhibitor; AN8025, a multifunctional fusion protein acting as a T cell and antigen-presenting cell (APC) modulator; and AN9025, an oral small molecule pan-rat sarcoma virus (RAS) inhibitor. The Company’s subsidiary, Alpine Bioscience Ltd. (Alpine BVI), is an investment holding company.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Adlai Nortye Doses First Patient in AN9025 Clinical Trial
- Clinical Trial Launch: Adlai Nortye successfully dosed the first patient in the U.S. with AN9025, an oral pan-RAS inhibitor, marking a significant milestone in its clinical strategy and expected to drive innovation in cancer treatment.
- Multicenter Trial Design: The Phase 1 clinical trial is designed as a multicenter, open-label study to evaluate the safety and anti-tumor activity of AN9025 in patients with advanced or metastatic solid tumors, demonstrating the company's commitment to advancing cancer therapies globally.
- Partnership Collaboration: Adlai Nortye is conducting this multi-regional clinical trial in collaboration with Jiangsu Aosaikang Pharmaceutical Co. Ltd., securing market rights in mainland China, Hong Kong, and Macao, which enhances its strategic positioning and partnership capabilities in the Asia-Pacific region.
- R&D Potential: AN9025 has shown potent inhibition against pancreatic, lung, and colorectal adenocarcinomas, indicating its broad application potential in future cancer therapies, which could provide the company with significant competitive advantages in the market.
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- Significant Financing: Adlai Nortye announced a $140 million private placement equity financing, selling approximately 64.6 million Class A ordinary shares at $2.1667 each, indicating strong market confidence in its innovative therapies.
- Key Investor Support: The placement includes about $55 million of Class A shares sold to entities controlled by Chairman and CEO Yang Lu, demonstrating the management's strong belief in the company's future growth.
- Positive Stock Reaction: Following the financing announcement, Adlai Nortye's stock price surged approximately 25% in pre-market trading on Tuesday, reflecting investor optimism about the company's prospects and potentially attracting further interest.
- Strategic Implications: Yang Lu noted that this financing attracted a high-quality group of healthcare investors to support Adlai Nortye's innovative and potentially best-in-class RAS-targeting therapies, further solidifying the company's market position in the biopharmaceutical sector.
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- Clinical Trial Launch: Adlai Nortye successfully dosed the first patient in the U.S. with AN9025, an oral pan-RAS inhibitor, marking a significant milestone in its clinical strategy and expected to drive innovation in cancer treatment.
- Multicenter Trial Design: The Phase 1 clinical trial is designed as a multicenter, open-label study to evaluate the safety and anti-tumor activity of AN9025 in patients with advanced or metastatic solid tumors, demonstrating the company's commitment to advancing cancer therapies globally.
- Partnership Collaboration: Adlai Nortye is conducting this multi-regional clinical trial in collaboration with Jiangsu Aosaikang Pharmaceutical Co. Ltd., securing market rights in mainland China, Hong Kong, and Macao, which enhances its strategic positioning and partnership capabilities in the Asia-Pacific region.
- R&D Potential: AN9025 has shown potent inhibition against pancreatic, lung, and colorectal adenocarcinomas, indicating its broad application potential in future cancer therapies, which could provide the company with significant competitive advantages in the market.
See More
Adlai Nortye Secures $140M Private Placement Financing
- Significant Financing: Adlai Nortye announced a $140 million private placement equity financing, selling approximately 64.6 million Class A ordinary shares at $2.1667 each, indicating strong market confidence in its innovative therapies.
- Key Investor Support: The placement includes about $55 million of Class A shares sold to entities controlled by Chairman and CEO Yang Lu, demonstrating the management's strong belief in the company's future growth.
- Positive Stock Reaction: Following the financing announcement, Adlai Nortye's stock price surged approximately 25% in pre-market trading on Tuesday, reflecting investor optimism about the company's prospects and potentially attracting further interest.
- Strategic Implications: Yang Lu noted that this financing attracted a high-quality group of healthcare investors to support Adlai Nortye's innovative and potentially best-in-class RAS-targeting therapies, further solidifying the company's market position in the biopharmaceutical sector.
See More
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- Disappointing Delivery Numbers: Xpeng Inc reported delivering 20,011 vehicles in January 2026, a figure that, while substantial, fell short of market expectations, leading to a decline in investor confidence.
- Stock Price Reaction: Following the disappointing delivery results, Xpeng's stock dropped 5.6% in pre-market trading to $16.97, reflecting concerns about the company's future performance among investors.
- Overall Market Trend: U.S. stock futures were lower, with Dow futures falling around 100 points, indicating a cautious market sentiment that could further impact investor attitudes towards Xpeng.
- Industry Impact: The delivery figures from Xpeng may negatively affect overall confidence in the electric vehicle market, especially in an increasingly competitive landscape, prompting investors to reassess their strategies.
See More
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- Strong Earnings Report: SanDisk's second-quarter results exceeded expectations, leading to a 20.9% surge in pre-market trading, with shares reaching $652.00, indicating strong market confidence in its financial health.
- Optimistic Q3 Guidance: The company forecasts third-quarter revenue between $4.4 billion and $4.8 billion, with non-GAAP diluted earnings per share expected to be between $12 and $14, suggesting ongoing improvement in growth potential and profitability.
- Joint Venture Extension: SanDisk announced the extension of its joint venture with Japan's Kioxia Corp. until December 31, 2034, further solidifying their strategic partnership in storage technology and enhancing market competitiveness.
- Positive Market Reaction: The significant rise in stock price reflects investor optimism about the company's future prospects, which may also attract more institutional investors, thereby elevating the company's standing in the industry.
See More
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- Stock Surge: Baidu's announcement of a proposed spinoff of Kunlunxin (Beijing) Technology Co., Ltd. H shares for a separate listing on the Hong Kong Stock Exchange led to a 12.3% increase in its stock price to $146.69 in pre-market trading, indicating strong market enthusiasm for this strategic move.
- Spinoff Strategy: The spinoff aims to enhance Kunlunxin's independence and market valuation, which is expected to provide Baidu with more flexible capital operations and resource allocation, thereby strengthening its competitive position in the technology sector.
- Market Reaction: The spinoff news has sparked investor excitement, with the significant rise in Baidu's stock reflecting confidence in its future growth potential and likely attracting more institutional investors to its shares.
- Industry Impact: By pursuing this spinoff, Baidu can focus more on its core business while providing Kunlunxin with greater development space, which is anticipated to drive innovation and investment activity across the technology industry.
See More
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- Strong Market Reaction: The stock's robust performance in pre-market trading reflects optimistic investor sentiment regarding the privatization deal, potentially attracting more investor interest and enhancing the company's overall market capitalization.
- Significant Industry Impact: Fonar's privatization move may trigger similar actions among other medical device companies, prompting more firms in the sector to consider privatization to enhance operational efficiency and shareholder value.
- Future Strategic Direction: By going private, Fonar is expected to concentrate resources on its core business and optimize its operational model, thereby strengthening its market position and profitability in a highly competitive healthcare market.
See More
