Acrivon to Provide ACR-368 Clinical Data Updates in January 2026 Conference Call
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 17 2025
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Should l Buy ACRV?
Source: Newsfilter
- Clinical Data Update: Acrivon will provide updated clinical data for ACR-368 during a conference call in January 2026, focusing on the ongoing registrational-intent Phase 2b study, which is expected to significantly bolster the company's market positioning in endometrial cancer.
- New Development Candidate Nomination: The company will also announce a new preclinical development candidate, showcasing target disclosure for its AP3-driven cell cycle program, which will further enrich its pipeline and enhance competitive positioning in the market.
- ACR-2316 Progress: The Phase 1 study of ACR-2316 is advancing, with enrollment in the first three dose-escalation cohorts completed, and initial data showing tumor shrinkage at DL3, indicating promising clinical activity for this novel inhibitor.
- FDA Fast Track Designation: ACR-368 has received Fast Track designation from the FDA based on OncoSignature-predicted sensitivity, highlighting its potential value in treating endometrial cancer patients and enhancing the company's research and development outlook.
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Analyst Views on ACRV
Wall Street analysts forecast ACRV stock price to rise
6 Analyst Rating
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 1.580
Low
7.00
Averages
10.50
High
19.00
Current: 1.580
Low
7.00
Averages
10.50
High
19.00
About ACRV
Acrivon Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing precision oncology medicines. It uses its precision Generative Phosphoproteomics platform, Acrivon Predictive Precision Proteomics (AP3), to develop its pipeline of oncology drug candidates. Its lead candidate, ACR-368, is a selective small molecule inhibitor which targets CHK1 and CHK2 at sub single-digit nM and single-digit nM potency in intact cells, respectively, in a registrational Phase II trial across multiple solid tumor types. Using its AP3 platform, it has developed a predictive OncoSignature test for ACR-368, called ACR-368 OncoSignature, that can predict patient response to ACR-368 monotherapy and therefore improve the clinical overall response rate (ORR) and has the potential to enable drug development. Its preclinical program, ACR-2316, is advancing in investigational new drug-enabling studies. It is a novel, dual WEE1 and PKMYT1 inhibitor small molecule development candidate.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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See More
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- Clinical Results Analysis: Despite a promising overall confirmed response rate of 52% in patients with the serous subtype of endometrial cancer, mixed interpretations of the data led to shaken market confidence, adversely affecting stock performance.
- Trial Expansion Plans: Acrivon announced plans to expand the trial into the European Union to accelerate patient enrollment, a strategic move aimed at enhancing the trial's effectiveness and market acceptance, although the stock remains under pressure in the short term.
- Surge in Trading Volume: The trading volume significantly exceeded average levels, reflecting investors' strong reactions to the clinical results, highlighting the high volatility and uncertainty prevalent in the biotech sector.
See More
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- Clinical Trial Progress: In the ACR-368 Phase 2b registrational trial for endometrial cancer, the overall response rate (ORR) was reported at 39%, with a notable 44% ORR in patients with more than two prior therapies, indicating the drug's potential in refractory cases.
- Targeted Strategy: Following the analysis of response rates in serous endometrial cancer patients, Arm 3 of the trial will focus exclusively on subjects with ≤2 prior treatments, aiming to enhance the trial's effectiveness and specificity.
- New Drug Development Update: Initial clinical data from ACR-2316 shows a tumor shrinkage rate of 45% in patients with small cell lung cancer and squamous non-small cell lung cancer at doses of 120 mg and above, providing a positive clinical basis for future treatment regimens.
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See More
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- Unit Labor Costs Decline: Unit labor costs in the nonfarm business sector fell by 1.9% in Q3, contrary to market expectations of a 1.0% increase, indicating successful cost control by businesses that could bolster profit margins.
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