Abpro and Celltrion Reveal Promising Preclinical Data for Bispecific T-Cell Engager ABP-102/CT-P72 Targeting HER2-Positive Cancers
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Apr 01 2025
0mins
Should l Buy ABP?
Source: NASDAQ.COM
Partnership Announcement: Abpro Holdings and Celltrion have formed a partnership to develop ABP-102/CT-P72, a bispecific T-cell engager targeting HER2-positive cancers, with clinical trials expected to begin in 2026.
Therapeutic Potential: Preclinical data suggests that ABP-102/CT-P72 may provide enhanced efficacy and safety compared to existing treatments by selectively targeting HER2-overexpressing tumors while minimizing toxicity to normal tissues.
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Analyst Views on ABP
About ABP
Abpro Holdings, Inc. is a biotechnology company. The Company is advancing a pipeline of next generation antibody therapies for human epidermal growth factor receptor 2 (HER2)+cancers, non-HER2+ gastric and liver cancer, and wet age-related macular degeneration and diabetic macular edema. These antibodies are developed using the Company’s proprietary DiversImmune platform. Its two lead product candidates, ABP-102 and ABP-201, feature its next generation tetravalent antibody format (TetraBi antibody format), which binds to two different targets with two distinct binding sites per target. ABP-102 is designed to redirect a patient’s immune system to fight cancer by engaging T cells through co-targeting HER2, and CD3, T-cell co-receptor. ABP-201 is designed to block blood vessel formation and normalize damaged vessels through co-targeting VEGF and ANG-2. It plans to develop ABP-201 to treat vascular disease of the eye, focusing on wet age-related macular degeneration (Wet AMD).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Significant Revenue Growth: The quarterly revenue reached $172.61 million, exceeding Wall Street's estimate of $161.36 million and up from $140.58 million in the same period last year, demonstrating the company's robust performance amid recovering market demand.
- Stock Price Surge: Fastly's shares jumped 34.8% to $12.55 in pre-market trading, reflecting a positive investor reaction to the earnings report, which may attract more investor interest in its future developments.
- Increased Market Confidence: The strong earnings report not only enhances investor confidence but may also prompt analysts to revise their ratings and price targets for the company, potentially driving further stock price increases.
See More
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- NASDAQ and S&P 500 Decline: In contrast to the Dow's rise, the NASDAQ fell by 0.34% to 23,159.55, while the S&P 500 dipped 0.07% to 6,960.28, reflecting weakness in tech stocks and other sectors.
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- Quarterly Growth Outlook: Credo also expects mid-single-digit sequential revenue growth to round out the year, suggesting continued strong performance in the coming months, which enhances investor confidence.
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- Safety and Selectivity: Preclinical studies demonstrate that ABP-102/CT-P72 exhibits selective activity in HER2-high tumor models and shows good tolerability in non-human primates, indicating its potential advantages in clinical applications.
- Milestone in Collaboration: The submission of this IND application reflects the productive partnership between Abpro and Celltrion, further advancing Abpro's overall progress in the immuno-oncology pipeline and enhancing its competitive position in the market.
- Future Growth Potential: The successful advancement of this project not only addresses the treatment needs of HER2-positive tumor patients but also may provide new growth opportunities for Abpro's antibody therapy pipeline, elevating the company's standing in the biotechnology sector.
See More
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- Clinical Trial Milestone: Abpro, in collaboration with Celltrion, has submitted an IND application for ABP-102/CT-P72, marking its first phase 1 trial in solid tumors, anticipated to commence in 1H 2026, aimed at providing new treatment options for HER2-positive cancer patients.
- Safety and Selectivity: Preclinical studies demonstrate that ABP-102/CT-P72 exhibits selective activity in HER2-high tumor models and was well tolerated in non-human primates, indicating a potentially favorable therapeutic index in clinical studies.
- Collaborative Development Advantage: This IND submission reflects the productive collaboration between Abpro and Celltrion, further advancing Abpro's immuno-oncology pipeline and enhancing its competitive position in the market.
- Future Growth Potential: The development of ABP-102/CT-P72 not only offers hope for HER2-positive tumor patients but may also drive long-term growth for Abpro in the oncology treatment sector through its unique therapeutic mechanism.
See More
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- Capital Strategy Optimization: The company has access to up to $44 million in equity financing to support operations and achieve long-term financial goals, enhancing stockholders' equity to maintain listing compliance.
- Significant Cost Optimization: By streamlining its structure, Abpro has achieved an estimated 60% reduction in operating expenses, improving financial health and laying a foundation for future growth.
- Pipeline Progress: Abpro's lead antibody candidate, ABP-102, is on track for first-in-human trials in 2026, showcasing the company's innovative potential and competitive edge in the biotechnology sector.
See More
